What if we could add 20 healthy years to our lives—starting today?

In this episode of The Beyond Tomorrow Podcast, longevity pioneer Matt Kaeberlein, CEO of OptiSpan and host of the OptiSpan Podcast, joins me for a sweeping conversation on the science, skepticism, and promise of human lifespan extension.

From rapamycin and thymic regeneration to the XPRIZE and biological age tests, Matt shares deeply honest insights about what is real, what is hype, and what might actually work. You will learn why human connection could be the most overlooked longevity hack, what tests truly matter, and how to think like a scientist in the era of consumer health fads.

🎧 Expect to learn:

• Why rapamycin remains the most promising anti-aging compound in animals

• The truth about biological age tests, microbiome kits, and health influencers

• Why Matt is cautiously optimistic about the longevity XPRIZE

• The 4 pillars of health that matter more than any supplement

• Why human connection is the most underrated predictor of joy and vitality

• How Matt is experimenting with therapeutic plasma exchange and thymic rejuvenation

• Why most startups chasing "longevity escape velocity" are missing the mark

📌 Plus: His surprisingly nuanced take on Bryan Johnson, and what Matt wants to do next in longevity.

Check out Matt's podcast: The Optispan Podcast with Matt Kaeberlein

🔔 Hit follow to stay ahead of the future of health.

🌍 Learn more: beyondtomorrowpodcast.com

📸 Instagram: @thebeyondtomorrowpodcast

⏱️ Timestamps:

0:00 – Intro
2:00 – Who Is Matt Kaeberlein & Why Longevity?
5:00 – Why Aging Is the #1 Health Problem
7:00 – Rapamycin: Hype, Hope & How It Might Work
10:00 – What Supplements Matt Actually Takes
13:00 – Plasma Exchange & Thymic Regeneration
17:00 – The Problem with Biohacking Culture
21:00 – Truth About Biological Age & Microbiome Tests
26:00 – Brian Johnson: What He’s Getting Right (and Wrong)
30:00 – Longevity Escape Velocity: Science or Sci-Fi?
34:00 – What the XPRIZE for Longevity Could Unlock
38:00 – Diagnostics That Actually Matter
42:00 – Why Human Connection Is the Ultimate Health Hack
45:00 – Hormones, DEXA, CGMs & Labs That Help
48:00 – What Matt Has Changed His Mind On
49:00 – What Brings Joy: The Real Point of Living Longer
50:00 – Final Thoughts & Where to Learn More

This podcast is for informational purposes only and is not medical advice

What if one scan could reveal hidden health risks and change how you live?

In this episode, Prenuvo Founder & CEO Andrew Lacy explains how their full-body MRI is transforming healthcare by catching disease before it starts. With the power to detect over 500 conditions, including cancer and aneurysms, Prenuvo is pioneering a proactive, consumer-driven approach to health.

🎁 Beyond Tomorrow listeners get $300 off your Prenuvo scan (we take no commission!): prenuvo.com/BEYONDTOMORROW

🌐 Learn more: beyondtomorrowpodcast.com

Expect to Learn:

• How Prenuvo’s 45-minute MRI scan detects up to 500 conditions, including early-stage cancer

• Why 1 in 20 scans delivers a potentially life-saving diagnosis

• Surprising insights that blood tests miss, like organ damage from lifestyle

• The future of healthcare as a “one-stop shop” for annual physicals

• Why mindset and consumer-driven health are transforming a reactive system

• Andrew’s journey from stressed entrepreneur to preventative health pioneer

  
  

Timestamps:

0:00 Intro to Prenuvo & Andrew’s Mission

5:00 Inside a Prenuvo Scan

8:00 Why Organ Imaging Matters

12:00 Shocking Scan Discoveries

15:00 MRI vs. Other Tests

18:00 Facing Health Fears

22:00 AI, Wearables & Health’s Future

26:00 Honest Health Feedback

30:00 Prenuvo’s Global Expansion

35:00 Debunking Health Myths

40:00 Preventative Health by 2030

45:00 Consumer-Driven Care

50:00 Starting Your Prenuvo Journey

🔔 Follow Beyond Tomorrow on Spotify for more inspiring episodes!

This content is for informational purposes only and not medical advice. Consult a healthcare professional before making health changes.

🔗 Connect With Us:

Instagram: @thebeyondtomorrowpodcast / @prenuvo

TikTok: @thebeyondtomorrowpodcast / @prenuvo

LinkedIn: The Beyond Tomorrow Podcast / Prenuvo

Website: beyondtomorrowpodcast.com / prenuvo.com

Peter Diamandis is a visionary entrepreneur, futurist, and longevity advocate helping humanity extend its healthspan and thrive in an era of exponential change. He is the founder of the XPRIZE Foundation, Singularity University, and Abundance360.

In this episode, we dive into what Peter calls the "longevity mindset"—a way of thinking that replaces fear with purpose, and scarcity with abundance. He explains why we may reach longevity escape velocity by 2030, how AI is revolutionizing diagnostics, and what it will take to close the gap between lifespan and healthspan for everyone.

With the upcoming semifinalists being announced, we also explore Peter’s most ambitious initiative yet: The $101 million Healthspan XPRIZE, a global competition launched by the XPRIZE Foundation aiming to reverse biological aging and extend healthy years of life by at least 20 years, with 603 teams already racing toward this moonshot.

Expect to learn:

• What it really means to reach longevity escape velocity—and why it could happen this decade

• The mindset shifts that add not just years to your life, but vitality to your years

• How Peter is mobilizing 603 global teams to reverse aging through the Healthspan XPRIZE

• The reason most of us self-limit our lifespans—and how to break free

• Why optimism and purpose are two of the strongest predictors of longevity

• How AI is accelerating biological breakthroughs faster than ever imagined

• Why Peter believes aging is the biggest disease of all—and one we can overcome

📸 Instagram: @beyondtomorrowpodcast | @peterdiamandis
🌍 Website: www.diamandis.com | www.xprize.org
📩 Email: bookings@beyondtomorrowpodcast.com

🎙 Hosted by Julian Issa
📍 Subscribe to The Beyond Tomorrow Podcast with Julian Issa for more conversations shaping your future.

Timestamps:

0:00 Intro

2:06 Finding purpose: Why Peter was born

3:45 Peter’s four “Massive Transformative Purposes”

6:12 What is longevity escape velocity?

9:10 The case for living to 150+

12:45 Why the next decade will transform aging

15:20 What the Healthspan XPRIZE is really aiming for

18:22 AI’s role in reversing aging and saving lives

21:00 How Fountain Life is creating 200GB health uploads

25:00 Gene therapy, affordability, and access

28:00 Common pushbacks: overpopulation, boredom, inequality

32:00 Why optimism adds 15% to your lifespan

35:00 What Peter teaches his children about the future

38:00 Mindsets that matter: exponential, abundance, purpose

41:00 Daily habits and mental frameworks for longevity

44:00 Education, AI, and the future of learning

47:00 2030: A world with humanoid robots and extended healthspans

50:00 How to get involved with XPRIZE

51:30 Closing thoughts

Meredith Perry is the founder of Elemind Technologies, a neurotech company building wearable devices that transform sleep and brain health through real-time brainwave stimulation. A former NASA researcher and MIT graduate, Meredith is pioneering the future of "electronic medicines"—non-invasive treatments that could replace drugs with precise brain modulation.

In this conversation, we explore how Elemind’s wearable technology helps users fall asleep faster by disrupting wakefulness brainwaves, why sleep is the ultimate force multiplier for health, and how personalized brainwave tracking could shape the future of medicine, mental health, and longevity.

We also dive into the science behind alpha, theta, and delta brainwaves, the evolution of sleep technology, and Meredith’s bold predictions for where neurotech is heading.

Expect to learn:

• Why the future of medicine might be non-invasive neurostimulation.

• How Elemind's headband uses EEG sensors and AI to personalize brain stimulation.

• Why sleep is crucial for memory, immune health, and mental resilience.

• How brainwave modulation could treat sleep, tremor, pain, and depression.

• How personalized brain data will reshape healthcare.

• Meredith's vision for the next wave of neurotechnology by 2030.

  
  

📸 Instagram: @meredithperry | @juliankissa
🌍 Website: elemindtech.com | beyondtomorrowpodcast.com
📩 Email: bookings@beyondtomorrowpodcast.com

🎙 Hosted by Julian Issa
📍 Subscribe to The Beyond Tomorrow Podcast for more stories from the frontier of health, longevity, and human potential.

Timestamps:

0:00 Introduction and Meredith’s Journey
3:10 Why Sleep Became the First Target for Elemind
6:30 Rethinking Medicine: Electronics vs Chemicals
9:40 How Elemind’s Brainwave “Noise Cancellation” Works
12:50 Brainwaves Explained: Alpha, Theta, Delta
16:00 Why Now Is the Tipping Point for Neurotech
19:10 Real-Time Brain Modulation for Personalized Health
22:20 Sleep Data Accuracy: EEG vs Wearables
25:30 Sleep Score Anxiety and Health Gamification
28:40 Who Elemind Helps (and Limitations)
31:50 Future of Neurotech: Beyond Sleep
35:00 How Phones and Light Disrupt Sleep
38:10 How Meredith Changed Her Own Sleep Habits
41:20 What’s Next: Deep Sleep Enhancement and AI
44:30 Closing Thoughts: Future of Brain Health and Sleep

Max Marchione is the founder of Superpower, a health optimization startup that recently raised its Series A to help people live longer, healthier, and more energized lives. He’s one of the most forward-thinking voices in biotech and wellness, blending science, supplements, and systems thinking to reimagine how we approach health and happiness.

This episode is part of Beyond Highlights—a new series of 10-minute excerpts from full episodes that offer powerful insights you can apply today, and take with you beyond tomorrow.

In this highlight, we explore GLP-1s and their potential to reverse obesity, why foundational health matters more than hacks, and how surrender, sunlight, and authenticity may be the most potent medicine of all.

Expect to learn:

Why GLP-1s mark a turning point in public health—and what comes next.
How happiness is downstream of gut, metabolic, and hormonal health.
Why Max believes multivitamins and mineral balance are undervalued keys to performance.
How The Untethered Soul reshaped the way Max lives, builds, and leads.
What makes authenticity the ultimate fuel for vitality—and why a life of ease might not be the answer.
And how the future of health is both radically innovative and deeply human.

📸 Instagram: @thebeyondtomorrowpodcast | @maxmarchione | @superpower.health
🌍 Website: www.beyondtomorrowpodcast.com
📩 Email: bookings@beyondtomorrowpodcast.com

🎙 Hosted by Julian Issa
📍 Subscribe to The Beyond Tomorrow Podcast with Julian Issa for more stories from the edge of what’s possible.

Tina Woods is a longevity strategist, systems thinker, and pioneer of the Human Exposome Project, a bold scientific and societal initiative redefining health as a collective endeavor. Pete Ward is a serial tech entrepreneur & co-founder of Humanity, a healthtech company using AI to help people extend their healthspan at scale. Together, they bring a powerful dual lens to the future of human health: systems change and individual action.

In this wide-ranging episode, we explore why the future of longevity will not be won through biohacking alone—but through radically reimagining the environments we live in. From air quality and loneliness to digital infrastructure, biomarkers, and government policy, Tina and Pete unpack the systemic drivers of healthy aging, and what it will take to change the odds for everyone, not just the 1%.

Timestamps

00:00 Introducing the Human Exposome Project

04:52 What really drives longevity: environment vs. genetics

09:53 The economic case for prevention

13:19 What Singapore and the Middle East are doing right

18:03 Building cities for healthspan and human flourishing

22:07 Private sector vs. public sector: who leads change?

25:17 Incentives, missions, and shifting mindsets

29:42 The risk of over-supplementation and longevity clinics

34:06 Why testing, tracking, and N=1 still matter

39:27 Can AI make personalized prevention equitable?

44:35 Predictive models and the next biological clocks

49:03 Are we waiting too long for consensus in science?

52:28 Individual action vs. collective environment

54:41 Data philanthropy and new public health models

58:35 A billion-dollar longevity strategy

1:03:27 The moonshot vision for 2030

1:06:17 Closing reflections on humanity, purpose, and hope

Expect to learn:

Why the exposome, the totality of our lifetime exposures, may matter more than our genome

What country has itself the trailblazer and example for the Exposome Project

Why loneliness is one of the biggest killers—and what real community interventions look like

How AI can personalize prevention without widening inequality

What Tina and Pete would do with a billion dollars to transform global health

And why the most powerful biological clock of the future may be one that measures joy, not just biomarkers

📸 Instagram: @thebeyondtomorrowpodcast | @tina.technotic | @petavard | @juliankissa
🌍 Website: thebeyondtomorrowpodcast.com / humanity.health / exposomemoonshot.org / information on Human Exposome Project can be found here: https://www.colliderhealth.com/
📩 Email: bookings@beyondtomorrowpodcast.com

🎙 Hosted by Julian Issa
📍 Subscribe to The Beyond Tomorrow Podcast for more conversations at the intersection of science, systems, and human flourishing.

Michele Costa is a transpersonal psychotherapist and shamanic practitioner, and Ruben Orellana is the former head archaeologist at Machu Picchu, an anthropologist and a revered curandero with over 48 years of experience working with sacred plant medicines like San Pedro and Ayahuasca. Together, they bring a rare blend of Indigenous wisdom and Western training to help people heal, emotionally, spiritually, and physically.

In this illuminating and soul-stirring episode, we journey through the ancient world of plant medicine, where healing is not about fixing symptoms but remembering who we truly are. Michele and Ruben share stories of transformation, initiation, and the vital role of play, presence, and ritual in our healing journeys.

Expect to learn:

- How vibrational medicine helps us release what is held in the body.

- How plant medicines like Ayahuasca and San Pedro work not only on the mind, but on the liver, the heart, and deep ancestral wounds.

- Why laughter, play, and connecting with nature are some of the most potent medicines we have.

- How colonial influence and, more recently, an increasing Western appetite has distorted plant medicine traditions and why restoring reverence is crucial for their survival.

- The difference between working with psychedelics and true entheogens, and why intention and ceremony matter.

- Why consciousness is the medicine of the future and how crises may be the catalyst that finally brings us home to ourselves.

📸 Instagram: @thebeyondtomorrowpodcast | @juliankissa | @shamanicspace

🌍 Website: thebeyondtomorrowpodcast.com | @shamanicspace.com

📩 Email: bookings@beyondtomorrowpodcast.com

🎙 Hosted by Julian Issa

📍 Subscribe to The Beyond Tomorrow Podcast with Julian Issa for more stories from the edge of what’s possible.

DISCLAIMER:

Please note that the information shared in this podcast is for educational and informational purposes only. Always consult with a qualified healthcare professional before making any decisions regarding the use of plant medicines like ayahuasca or San Pedro. Additionally, be sure to understand and respect the legal status of these substances in your location, as they are illegal in many countries. Your safety and well-being are our top priorities.

Timestamps:

0:00 Intro

3:11 Ruben’s childhood and first encounter with curanderismo

6:06 Initiations, lightning strikes, and the making of a healer

10:44 Michele’s early life, spiritual upbringing, and healing journey

17:59 The wisdom of San Pedro and what it really means to “see”

23:46 The western distortion of Indigenous diets, rituals, and language

28:29 Michele’s life-changing experience with Ayahuasca

34:30 What’s happening at a cellular level during ceremony

41:46 How Michele and Ruben “see” energy in others during healing

47:17 Intergenerational trauma, cellular memory, and systemic wounding

53:01 How plant medicine helps us feel, release, and return to being

57:24 Is plant medicine for everyone? What to know before you start

1:03:15 The future of consciousness and Ruben’s 10-year outlook

1:17:43 The forgotten role of the healer: restoring harmony for others

Nidhi Pandya is an Ayurvedic doctor, writer, and teacher helping people reconnect with ancient Vedic wisdom to heal their bodies, calm their minds, and live more intuitively. She is the author of Your Body Already Knows: Intuitive Ayurveda, a 21-day guide to resetting your gut, sleep, and overall health.

In this episode, we dive into the science of ancient healing, why your inner climate matters more than supplements, how simple lifestyle shifts can help you live longer without "biohacking" your biology, and much more.

Expect to learn:

Why Nidhi believes Ayurveda is the original science of life, and how it could transform your daily wellbeing.
How ancient rituals like oiling, cooked foods, and breathwork hold the keys to modern health and longevity.
Why the first sign of disease in Ayurveda is not physical—but a loss of wisdom.
How warm and moist became the unlikely foundation for gut health, hormone balance, and emotional connection.
Why 21 days could be all it takes to reset your body and reconnect with your intuition.
And how to live longer without hacking your biology.

📸 Instagram: @thebeyondtomorrowpodcast | @nidhipandya | @juliankissa
🌍 Website: Nidhi.me
📩 Email: bookings@beyondtomorrowpodcast.com

🎙 Hosted by Julian Issa
📍 Subscribe to The Beyond Tomorrow Podcast with Julian Issa for more stories from the edge of what’s possible.

Timestamps:
0:00 Intro
2:06 What is Ayurveda and why it matters today
3:30 Growing up in a Vedic household
5:52 Learning through rhythms, not instructions
7:01 Rituals, intuition, and generational wisdom
10:23 How bio-individuality shaped her upbringing
14:19 Why she wrote Your Body Already Knows
18:50 The three governing principles of health
21:26 Principle 1: Creating a warm and moist internal climate
26:38 Simple ways to support your body daily
30:14 Principle 2: Aligning with circadian rhythms
34:35 Principle 3: Embracing the cycles of growth, transformation, and decay
37:09 Can Ayurveda and modern wellness coexist?
41:06 Misconceptions and health trends to avoid
44:22 The science behind sleep, oiling, and gut balance
46:28 Breathwork, resonance breathing & humming
48:59 Alternate nostril breathing practice (live demo)
52:35 What the Ayurvedic future looks like in NYC, SF & London
54:38 What happens after the 21-day reset
56:45 Ayurveda, longevity & biohacking—what’s the difference?
59:27 Final thoughts on mortality, aging, and purpose