What if we could add 20 healthy years to our lives—starting today?

In this episode of The Beyond Tomorrow Podcast, longevity pioneer Matt Kaeberlein, CEO of OptiSpan and host of the OptiSpan Podcast, joins me for a sweeping conversation on the science, skepticism, and promise of human lifespan extension.

From rapamycin and thymic regeneration to the XPRIZE and biological age tests, Matt shares deeply honest insights about what is real, what is hype, and what might actually work. You will learn why human connection could be the most overlooked longevity hack, what tests truly matter, and how to think like a scientist in the era of consumer health fads.

🎧 Expect to learn:

• Why rapamycin remains the most promising anti-aging compound in animals

• The truth about biological age tests, microbiome kits, and health influencers

• Why Matt is cautiously optimistic about the longevity XPRIZE

• The 4 pillars of health that matter more than any supplement

• Why human connection is the most underrated predictor of joy and vitality

• How Matt is experimenting with therapeutic plasma exchange and thymic rejuvenation

• Why most startups chasing "longevity escape velocity" are missing the mark

📌 Plus: His surprisingly nuanced take on Bryan Johnson, and what Matt wants to do next in longevity.

Check out Matt's podcast: The Optispan Podcast with Matt Kaeberlein

🔔 Hit follow to stay ahead of the future of health.

🌍 Learn more: beyondtomorrowpodcast.com

📸 Instagram: @thebeyondtomorrowpodcast

⏱️ Timestamps:

0:00 – Intro
2:00 – Who Is Matt Kaeberlein & Why Longevity?
5:00 – Why Aging Is the #1 Health Problem
7:00 – Rapamycin: Hype, Hope & How It Might Work
10:00 – What Supplements Matt Actually Takes
13:00 – Plasma Exchange & Thymic Regeneration
17:00 – The Problem with Biohacking Culture
21:00 – Truth About Biological Age & Microbiome Tests
26:00 – Brian Johnson: What He’s Getting Right (and Wrong)
30:00 – Longevity Escape Velocity: Science or Sci-Fi?
34:00 – What the XPRIZE for Longevity Could Unlock
38:00 – Diagnostics That Actually Matter
42:00 – Why Human Connection Is the Ultimate Health Hack
45:00 – Hormones, DEXA, CGMs & Labs That Help
48:00 – What Matt Has Changed His Mind On
49:00 – What Brings Joy: The Real Point of Living Longer
50:00 – Final Thoughts & Where to Learn More

This podcast is for informational purposes only and is not medical advice

What if one scan could reveal hidden health risks and change how you live?

In this episode, Prenuvo Founder & CEO Andrew Lacy explains how their full-body MRI is transforming healthcare by catching disease before it starts. With the power to detect over 500 conditions, including cancer and aneurysms, Prenuvo is pioneering a proactive, consumer-driven approach to health.

🎁 Beyond Tomorrow listeners get $300 off your Prenuvo scan (we take no commission!): prenuvo.com/BEYONDTOMORROW

🌐 Learn more: beyondtomorrowpodcast.com

Expect to Learn:

• How Prenuvo’s 45-minute MRI scan detects up to 500 conditions, including early-stage cancer

• Why 1 in 20 scans delivers a potentially life-saving diagnosis

• Surprising insights that blood tests miss, like organ damage from lifestyle

• The future of healthcare as a “one-stop shop” for annual physicals

• Why mindset and consumer-driven health are transforming a reactive system

• Andrew’s journey from stressed entrepreneur to preventative health pioneer

  
  

Timestamps:

0:00 Intro to Prenuvo & Andrew’s Mission

5:00 Inside a Prenuvo Scan

8:00 Why Organ Imaging Matters

12:00 Shocking Scan Discoveries

15:00 MRI vs. Other Tests

18:00 Facing Health Fears

22:00 AI, Wearables & Health’s Future

26:00 Honest Health Feedback

30:00 Prenuvo’s Global Expansion

35:00 Debunking Health Myths

40:00 Preventative Health by 2030

45:00 Consumer-Driven Care

50:00 Starting Your Prenuvo Journey

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This content is for informational purposes only and not medical advice. Consult a healthcare professional before making health changes.

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Instagram: @thebeyondtomorrowpodcast / @prenuvo

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LinkedIn: The Beyond Tomorrow Podcast / Prenuvo

Website: beyondtomorrowpodcast.com / prenuvo.com

Peter Diamandis is a visionary entrepreneur, futurist, and longevity advocate helping humanity extend its healthspan and thrive in an era of exponential change. He is the founder of the XPRIZE Foundation, Singularity University, and Abundance360.

In this episode, we dive into what Peter calls the "longevity mindset"—a way of thinking that replaces fear with purpose, and scarcity with abundance. He explains why we may reach longevity escape velocity by 2030, how AI is revolutionizing diagnostics, and what it will take to close the gap between lifespan and healthspan for everyone.

With the upcoming semifinalists being announced, we also explore Peter’s most ambitious initiative yet: The $101 million Healthspan XPRIZE, a global competition launched by the XPRIZE Foundation aiming to reverse biological aging and extend healthy years of life by at least 20 years, with 603 teams already racing toward this moonshot.

Expect to learn:

• What it really means to reach longevity escape velocity—and why it could happen this decade

• The mindset shifts that add not just years to your life, but vitality to your years

• How Peter is mobilizing 603 global teams to reverse aging through the Healthspan XPRIZE

• The reason most of us self-limit our lifespans—and how to break free

• Why optimism and purpose are two of the strongest predictors of longevity

• How AI is accelerating biological breakthroughs faster than ever imagined

• Why Peter believes aging is the biggest disease of all—and one we can overcome

📸 Instagram: @beyondtomorrowpodcast | @peterdiamandis
🌍 Website: www.diamandis.com | www.xprize.org
📩 Email: bookings@beyondtomorrowpodcast.com

🎙 Hosted by Julian Issa
📍 Subscribe to The Beyond Tomorrow Podcast with Julian Issa for more conversations shaping your future.

Timestamps:

0:00 Intro

2:06 Finding purpose: Why Peter was born

3:45 Peter’s four “Massive Transformative Purposes”

6:12 What is longevity escape velocity?

9:10 The case for living to 150+

12:45 Why the next decade will transform aging

15:20 What the Healthspan XPRIZE is really aiming for

18:22 AI’s role in reversing aging and saving lives

21:00 How Fountain Life is creating 200GB health uploads

25:00 Gene therapy, affordability, and access

28:00 Common pushbacks: overpopulation, boredom, inequality

32:00 Why optimism adds 15% to your lifespan

35:00 What Peter teaches his children about the future

38:00 Mindsets that matter: exponential, abundance, purpose

41:00 Daily habits and mental frameworks for longevity

44:00 Education, AI, and the future of learning

47:00 2030: A world with humanoid robots and extended healthspans

50:00 How to get involved with XPRIZE

51:30 Closing thoughts