Showing titles in Genetics

Alice Roberts uses the latest research to uncover the evolutionary history hidden in all of us, from the secrets found only in our embryos and genes - including why as embryos we have what look like gills - to those visible in your anatomy. This is a tale of discovery, exploring why and how we have developed as we have. This is your story, told as never before.

This is a story about you. It is the history of who you are and how you came to be. It is unique to you, as it is for every one of the 100 billion modern humans who has ever drawn breath. But it is also our collective story, because in each of our genomes we carry the history of the whole of our species.

As the planet emerged from the last ice age, a language was born between Europe and Asia, by the Black Sea. This ancient tongue, which we call Proto-Indo-European, soon exploded out of its cradle, changing and fragmenting as it went, until its offspring were spoken from Scotland to China. Today those descendants constitute the world’s largest language family, the thread that connects disparate cultures: Dante’s Inferno to the Rig Veda, The Lord of the Rings to the love poetry of Rumi. Indo-European languages are spoken by nearly half of humanity. How did this happen?

An almost limitless archive of our history lies hidden inside our bodies, and this book traces the ancient story of Scotland from that scientific viewpoint. The mushrooming of genetic studies, of DNA analysis, is rewriting history in spectacular fashion. In Scotland: A Genetic Journey, Alistair Moffat explores the history that is printed on our genes, and in a remarkable new approach, uncovers the detail of where Scots are from, where they have journeyed, and who they are - and in so doing, vividly colors in a DNA map of Scotland.

Genome unravels the secrets of human nature without the usual reams of technical jargon. It shows outstanding breakthroughs in gene research, how we've gone from knowing almost nothing to knowing almost everything, and how our genes reveal more about our past, our evolution, and even our minds. Every important event in human history is written into our genes, whether it happened four billion or a few hundred years ago. All you need to know is where to look.

A preeminent geneticist hunts the Neanderthal genome to answer the biggest question of them all: what does it mean to be human? What can we learn from the genes of our closest evolutionary relatives? Neanderthal Man tells the story of geneticist Svante Pbo’s mission to answer that question, beginning with the study of DNA in Egyptian mummies in the early 1980s and culminating in his sequencing of the Neanderthal genome in 2009.

In the spring of 2012, the Berkeley biochemist Jennifer Doudna and her collaborators turned a curiosity of nature into an invention that will transform the future of the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. It has already been deployed to cure deadly diseases, fight the coronavirus pandemic of 2020, and make inheritable changes in the genes of babies.

For decades, the medical community has looked to a variety of reasons for why we age, and the consensus is that no-one dies of old age; they die of age-related diseases. That's because ageing is not a disease - it is inevitable. But what if everything you think you know about ageing is wrong? What if ageing is a disease? And that disease is curable. In Lifespan, Dr David Sinclair, one of the world’s foremost authorities on genetics and ageing, argues just that.

In this groundbreaking approach to the evolution of all life, Richard Dawkins shows how the body, behaviour, and genes of every living creature can be read as a book – an archive of the worlds of its ancestors. A perfectly camouflaged desert lizard has a desiccated landscape of sand and stones ‘painted’ on its back. Its skin can be read as a description of ancient deserts in which its ancestors survived – and, before that, of the worlds of its more remote ancestors: a genetic book of the dead.

The Gene is the story of one of the most powerful and dangerous ideas in our history, from best-selling, prize-winning author Siddhartha Mukherjee. Spanning the globe and several centuries, The Gene is the story of the quest to decipher the master code that makes and defines humans, that governs our form and function. The story of the gene begins in an obscure Augustinian abbey in Moravia in 1856, where a monk stumbles on the idea of a 'unit of heredity'.

Richard Dawkins' brilliant reformulation of the theory of natural selection has the rare distinction of having provoked as much excitement and interest outside the scientific community as within it. His theories have helped change the whole nature of the study of social biology, and have forced thousands to rethink their beliefs about life.

In November 1987, a young couple on an overnight trip to Seattle vanished without a trace. A week later, the bodies of Tanya Van Cuylenborg and her boyfriend Jay Cook were found in rural Washington. It was a brutal crime, and it was the perfect crime: With few clues and no witnesses, an international manhunt turned up empty, and the sensational case that shocked the Pacific Northwest gradually slipped from the headlines.

Epigenetics is the science of living DNA, charting the chemical pathways that spur DNA into action by turning genes on and off. While the Human Genome Project of the early 2000s was hailed as the key to understanding human heredity and disease, that historic effort was just the beginning. It has taken epigenetics to fill in the picture, explaining how the fixed code of our genome is implemented in countless living processes.

In 1994 Professor Bryan Sykes, a leading world authority on DNA and human evolution, was called in to examine the frozen remains of a man trapped in glacial ice in northern Italy. News of both the Ice Man's discovery and his age, which was put at over 5,000 years, fascinated scientists and newspapers throughout the world. But what made Sykes's story particularly revelatory was his successful identification of a genetic descendant of the Ice Man, a woman living in Great Britain today. How was Sykes able to locate a living relative?

Everyone has heard of DNA. But by itself, DNA is just an inert blueprint for life. It is the ribosome - an enormous molecular machine made up of a million atoms - that makes DNA come to life, turning our genetic code into proteins and therefore into us. Gene Machine is an insider account of the race for the structure of the ribosome, a fundamental discovery that both advances our knowledge of all life and could lead to the development of better antibiotics against life-threatening diseases.

Stepping effortlessly from myth to cutting-edge science, Mutants gives a brilliant narrative account of our genetic code and the captivating people whose bodies have revealed it - a French convent girl who found herself changing sex at puberty; children who, echoing Homer's Cyclops, are born with a single eye in the middle of their foreheads; a village of long-lived Croatian dwarves; one family, whose bodies were entirely covered with hair, was kept at the Burmese royal court for four generations and gave Darwin one of his keenest insights into heredity.

Fifty thousand years ago, we were not the only species of human in the world. There were at least four others, including the Neanderthals, Homo floresiensis, Homo luzonesis and the Denisovans. At the forefront of the latter's ground-breaking discovery was Oxford Professor Tom Higham. In The World Before Us, he explains the scientific and technological advancements.

In this ground-breaking and entertaining exploration of athletic success, award-winning writer David Epstein gets to the heart of the great nature vs. nurture debate, and explodes myths about how and why humans excel. Along the way, Epstein exposes the flaws in the so-called 10,000-hour rule that states that rigorous practice from a young age is the only route to success.

With so much variation that can be handed down genetically, for better or worse, the way we understand our biology holds huge importance for how we understand our world and one another, including the biggest questions of our day, such as social inequality. Eye-opening and profound, Adaptable is a revolutionary reappraisal of an overlooked science.

The Ancestor's Tale is a pilgrimage back through time - a journey on which we meet up with fellow pilgrims as we and they converge on our common ancestors. Chimpanzees join us at about six million years in the past, gorillas at seven million years, orangutans at 14 million years, as we stride on together, a growing band. The journey provides the setting for a collection of some 40 tales.