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Lifespan

Why We Age - and Why We Don’t Have To
Narrated by: Dr David A. Sinclair
Length: 11 hrs and 55 mins
5 out of 5 stars (500 ratings)

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Publisher's Summary

In this paradigm-shifting audiobook from acclaimed Harvard Medical School doctor and one of Time magazine’s 100 most influential people on earth, Dr. David Sinclair reveals that everything we think we know about ageing is wrong, and shares the surprising, scientifically proven methods that can help listeners live younger, longer.

For decades, the medical community has looked to a variety of reasons for why we age, and the consensus is that no-one dies of old age; they die of age-related diseases. That's because ageing is not a disease - it is inevitable.

But what if everything you think you know about ageing is wrong? What if ageing is a disease? And that disease is curable.

In Lifespan, Dr David Sinclair, one of the world’s foremost authorities on genetics and ageing, argues just that. He has dedicated his life’s work to chasing more than a longer lifespan - he wants to enable people to live longer, healthier, and disease-free well into our hundreds. In this audiobook, he reveals a bold new theory of ageing, one that pinpoints a root cause of ageing that lies in an ancient genetic survival circuit.

This genetic trick - a circuit designed to halt reproduction in order to repair damage to the genome - has enabled earth’s early microcosms to survive and evolve into more advanced organisms.

But this same survival circuit is the reason we age: as genetic damage accumulates over our lifespans from UV rays, environmental toxins, and unhealthy diets, our genome is overwhelmed, causing gray hair, wrinkles, achy joints, heart issues, dementia, and, ultimately, death.

But genes aren’t our destiny; we have more control over them than we’ve been taught to believe. We can’t change our DNA, but we can harness the power of the epigenome to realise the true potential of our genes.

Drawing on his cutting-edge findings at the forefront of medical research, Dr Sinclair will provide a scientifically proven road map to reverse the genetic clock by activating our vitality genes, so we can live younger longer.

Readers will discover how a few simple lifestyle changes - like intermittent fasting, avoiding too much animal protein, limiting sugar, avoiding x-rays, exercising with the right intensity, and even trying cold therapy - can activate our vitality genes.

Dr Sinclair ends the audiobook with a look to the near future, exploring what the world might look like - and what will need to change - when we are all living well to 120 or more.

Dr Sinclair takes what we have long accepted as the limits of human potential and mortality and turns them into choices. Lifespan is destined to be the biggest book on genes, biology, and longevity of this decade.

PLEASE NOTE: When you purchase this title, the accompanying reference material will be available in your Library section along with the audio on our desktop site.

©2019 Dr David A. Sinclair (P)2019 HarperCollins Publishers Limited

Critic Reviews

"If you ever wondered how we age, if we can slow or even reverse aging, and if we can live a healthy 100 plus years, then David Sinclair’s new book Lifespan, which reads like a detective novel, will guide you through the science and the practical strategies to make your health span equal your lifespan, and make your lifespan long and vibrant." (Mark Hyman, MD Director, Cleveland Clinic Center for Functional Medicine and number one New York Times best-selling author)

"This is the most visionary book about aging I have ever read. Seize the day - and seize this book!" (Dean Ornish, MD, founder and president, Preventive Medicine Research Institute, and New York Times best-selling author of UnDo It!

What listeners say about Lifespan

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Amazing.

I been following David Sinclair for a while and the book "lifespan" has inspired me to fight ageing and take control of my life. I've always feared ageing when I was younger due to watching my grandparents die in their early 70's from age related illness's, it just scared me the thought of getting old and sick. I use to think we couldn't do anything about ageing but since following David and reading his work, I know now that we can slow the ageing process and may even be able to reverse it very soon. I can't recommend this book enough. Already ordered a few copies for my family members.

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Excellent book

This is a must read for anyone interested in living a longer healthier life, whatever your age (who isn’t?). Covers the science of aging by one of the leading researchers in the field of aging and genetics, in easy to understand plain language. Also addresses the moral and ethical issues around aging. Very well put together and thought provoking.

6 people found this helpful

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Good book but disagree with some conclusions

Much of the content in this book bothered me. I deeply appreciate David’s work and the passion he has for the subject is exactly what we need but I wish he would read the good work coming out of the field of functional medicine. Much of his nutrition knowledge is dated and was debunked in the last 10 years.

Animal protein is by far, the easiest to digestion and best source of many micronutrients, without which cause irreversible harm. Practitioners in functional medicine, regularly deal with vegetarians and vegans, that, after 10 years on the diet, suffer from irreversible low stomach acid production, specifically because the stomach is not exposed to animal protein.

We must steep all of our theories in evolutionary biology. Fasting works, because evolutionarily we adapter to periods of fasting. While humans can adapt to many different food sources, it is meat and specifically seafood that made use human. Our success over other hominids like from Neanderthal, was due to the introduction of seafood in our diet.

DHA and EPA cannot be obtained from a vegetarian diet and the conversion of ALA in to longer chain Omega 3 fatty acids is poor for much of the population.

Yes, mTOR is activated in response to > 25g of protein but this is any protein, including plant based proteins.

David, I propose that we leverage the benefits of mTOR and the benefits of autophagy. By going in and out of periods of fasting and periods of feeding. This way, mTOR and the hGH stimulated during fasting, builds healthy lean muscle tissue. If you say to keep animal aminos low constantly, you do two things:

1. People will never have enough amino acids to maintain healthy muscle and bone in to old age. Which becomes an issue as people age.
2. Amino acids necessary in liver detoxification and methylation for healthy brain function are not available

The above scenario, as is well known in functional medicine, leads to muscle wasting and mental health issues, typical in vegetarian populations.

The argument that nitrates in cured meat is detrimental to heal ignores three very important facts:

1. The highest source of nitrates/nitrites is celery
2. Vegetables are abundant in nitrates/nitrites as they absorb these from the nitrogen fertilisers used in agriculture
3. Studies on processed meat are never rigorous and suffer from confiunding variables like the healthy user bias and that in these studies, they do not screen out smokers or make the differentiation of processed meat with wheat or without as we know through Alessio Fasano’s work that gluten is having a much greater negative effect on health than the processed meat that is on these foods
4. The most important part of the equation is that certain guy flora convert nitrates/nitrites in to nitrosamines and gut health, irrespective of diet, has a much greater impact on levels of nitrosamines for this reason

The argument that TMAO in meat causes negative health effects is another argument that has been disproven many times. We know from observational studies that fish is beneficial and there is an almost linear relationship between fish consumption and health. Yes, there are confounders, but it cannot be overstated that fish and not red meat contain the highest amount of TMAO.

Your recommendation for GMOs as a source of vitamin A is flawed. Carotenoids found in these GMO crops that you reference are not in fact vitamin A. They are vitamin A precursors that require conversion in the body in to retinol. For many, this conversion is poor and as was the case for myself, if you do not get preformed retinol then you can suffer from the same effects of vitamin A deficiency despite consuming a large amount of carotenoids. The number once source of retinol is from liver, not from plants.

I highly suggest you checkout the good work that Chris Kresser and other functional medical docs are doing.

The pathway to longevity is not through drugs. There may in time be molecules that extend life span but only when the body is first healthy. This is done by identifying nutritional deficiencies and or imbalanced. Establishing great gut health and removing intestinal permeability. To lower or eliminate chronic stress through the use of meditation to decrease the size of the amygdala and to decrease activity in the default mode network. It is in the use of modbiotics and hormetic botanicals like turmeric and no, I disagree that isolated molecules are more potent than their natural counterparts as this has been shown in studies of curcumin versus the whole turmeric root.

I love what you do and I think you are brilliant, but please, invest some time in learning the brilliant work being done in the field of functional medicine. You must first have a healthy body through diet and lifestyle factors before you can extend that lifespan through the use of drugs.


54 people found this helpful

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Outstanding and truly awesome

Outstanding! A must read for anyone with a zest for a long and vibrant life.

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Excellent book. highly recommend

I found it engaging and informative! Enjoyed listening to it, about 2hour every day on the daily commute.

A great story intertwined with lots of science.

I believe it is a very balanced view of what us humans are capable of in terms of our potential lifespan and healthspan!

3 people found this helpful

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Science you can understand

This was a great listen- the robust science was accessible and cutting edge. Thought provoking and practical at the same time.

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Excellent book - a must read!

I had listened to David on the Rich Roll & Joe Rogan podcasts and when I heard he was bringing out a book, I knew I had to listen to it.
Lifespan didn’t disappoint.
From practical tips on improving longevity, to the science behind why we age, to considering the impacts on environment and society if we live longer.
David’s perspective is very optimistic and leaves the reader (listener) feeling hopeful and that a breakthrough in longevity science could happen at any time.
Highly recommend!

3 people found this helpful

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Hard to tell hopes from facts

The first part of the book was solid, but later I found it difficult to tell the difference between facts backed by evidence and the author's hopes and dreams. It's fine to speak one's opinions - im doing so now - but science gains credibility and avoids misinformation when it is explicitly clear which assertions are backed by evidence and which are not.

The second part on societal inpact could have been improved with more input from economists, psychologists, political scientists and philosophers, or perhaps be written as a separate book. There appeared to be some misconceptions on resource acquisition and re-distribution. Calls for conformity to certain moral values and calls for revolution were made. Labelling people bigots is like labelling people liars, everyone lies and everyone is bigoted; how much, about what and why, that's what matters.

The author seems to be interested in adding years of experience to people's lives but attacks people with many years of experience for their conservative fact checking. If it turns out brain plasticity is inversely related to years of experience (or time spent running a neural net), rather than cellular age; then longer lived humans may increase aversion to change despite them looking, acting and feeling young.

At the end of the day, this is still the best longevity book I've finished, and so it's worth a listen. Suggest learning with cautious optimism, and follow up on the findings which are best supported by the evidence. Be careful of wasting money and kidney health on supplements that may help mice but harm humans.

2 people found this helpful

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Great author and narrator

Brilliantly written and narrated! Love David's honest approach in disclosing all this research and his daily regimen plus his family's story. David is a wonderful narrator as his voice is so pleasant to hear and his conversational tone makes you feel like you are listening to a friend.

2 people found this helpful

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Essential for the layman

This book is essential for anyone who wants to be up to date on what aging is, and much more on the subject.

This book is probably best for the layman, although people that are long time enthusiasts on aging will still enjoy the book.

2 people found this helpful

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  • Jim
  • 07-01-2020

Will change your life, if you let it.

A book that so many around the world should read, if only a small amount of what is in this book it's taken on by everyone around the world it will be a big step forward. Great insights and food for thought.

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  • Robert Tessier
  • 26-12-2019

David Sinclair is one of the great human been

Thanks David to change the world the way you do.

This book should be teach to all student at school.

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  • beinloveart
  • 20-12-2019

Buy the paperback for all the people you love

It’s a beautiful book to listen to; and I can see that David Sinclair will be written in the history books as the man who fought to convert 21st century medicine scholars into focusing on ageing as a disease, rather than wasting so much of each countries taxed funds on individual diseases. He makes me so proud to be an Australian. Thanks David and family.

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  • Amazon Customer
  • 12-11-2019

Excellent! Loved the listen.

I would highly recommend this this audio book. I really enjoyed listening to all the latest research and understanding why things work the way they do. This book could potentially have a major impact on your life.

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  • Robert H
  • 28-10-2019

Mind Altering Book

One of the most life changing ( if I can use this expression) books I have ever read.
The warmth & deep sincerity of David Sinclair ( I used the audio book) resonates deeply.

1 person found this helpful

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  • Mario Tomic, MSc
  • 10-09-2019

Must-Read If You're Interesting in Healthy Aging

Coming from a perspective of someone who studies evidence-based nutrition, exercise, and healthy lifestyle factors for over a decade now, this book is a must-read. Solving aging is one of the final frontiers for humankind, and the information David has provided here is a big step in the right direction. It has the power to bring more awareness to solving aging as well as shift strong limiting beliefs that have been deeply rooted in public as well as the scientific community. We've come very far in research, but sadly the mainstream still hasn't caught up as many of the theories often mentioned have already been invalidated. Big thanks to David and his team for putting together all the most up-to-date longevity research in one place.

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  • Anonymous User
  • 18-02-2020

Best book on Longevity

Great book about achievements of longevity studies and positive perspective. Lots of great information. And David is simply amazing.

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  • Anonymous User
  • 18-02-2020

Insightful and useful read

Must read for anyone keen to learn and apply a little more to their well being. The cutting edge information on how to optimise your health is invaluable! Can't thank Dr Sinclair enough for his efforts and generosity for sharing information.

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  • SharonP
  • 24-10-2019

Inspiring, groundbreaking & profound

Thank you for pioneers like Dr David Sinclair who never gave up and in their quest are changing the world as we know it. Thank you David & Matt for putting so much information into this book, making it available to the public and understandable for laymen’s like me. It changed my world and I’m feeling much more positive about the future. Thank you so much! Grateful 🙏🏼

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  • Nitasha
  • 20-10-2019

Fascinating!

Loved this, bother the content and presentation. It’s an eye opener and I highly recommend it. It will make you much wiser.

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  • MastaRob
  • 18-12-2019

Good science bundled with annoying social justice

The book starts well, with a bit of biographical information that informs us why he is trying to help people live longer, and goes into some excellent science on the topic. I was fascinated by the history of his research into his own theory of ageing, how his and other theories have played out over time, and the current state of play. Unfortunately the final section is pure social theory, unsupported left wing talking points and climate alarmism presented as fact. Honestly when he makes statements about how he is proud he is of his son, who wants to become a social justice activist and politician, and that the world needs people like him to break the "global patriarchy" - then goes on to wonder at why his son is depressed and doesnt value his work to increase lifespan... well.... lets just say I'm suddenly re-evaluating everything else Sinclair says. I'll take his expertise on the science of ageing, but I think I'll pass on the rest. Damn shame, if he had spent the time focusing on the science, rather than pushing a social agenda or placing arguments down only for a specific demographic, the book could have been great.

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  • Amazon Customer
  • 20-11-2019

only two takeaways and allot of story telling

so to save time, restricting eating or intermittent fasting and take mnm and resveratrol. done your most welcome. book started well with an impacting intro but in the end especially towards the end of the book I had to speed it up to get to anything of note and at the end it was mostly about the writers visions and sales to government to give more funding.

17 people found this helpful

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  • Melton
  • 14-09-2019

This book will change your life and the world.

A lot of people are going to talk about the book. Get in ahead of the curve and read/listen to it now.

In David's own words this book will be out of date in 2/3 years because the science of longevity is evolvibg all the time. Which is a good thing. And I hope is get some revisions in a couple or years.

David has also taken the time to speak the book himself which is very time consuming and he should also receive merit for that too.

This book is amazing and definitely worth a listen.

I really hope a lot of people from governments and health organisations get to read/listen to it and talk about it. If this book doesn't change the world David Sinclair definitely will. It's science fiction coming true again just like self driving cars and free energy is also coming true.

I heard about the book from Dave Asprey and Dr Joe Mercola who's books are also worth a read/listen.

4 people found this helpful

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  • Ioan Evans
  • 22-01-2020

Informative

The information given on ageing and disease is invaluable. The stories were a bonus.

2 people found this helpful

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  • Mark Lancaster
  • 09-01-2020

Heady aspirations.

Life extension research and it's implications.
Personally I enjoyed the science parts at the beginning of the book. The implications of longer lives felt like it was turning into a sermon and went on too long for me.
On the whole exciting science though and Dr Sinclair definitely has the enthusiastic voice & experience to rally the charge.

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  • Elisi
  • 20-07-2020

Some interesting information

I read the book from cover to cover. I think the information he provides needs to be taken with a grain of salt, not the one about the possibility of expanding or lifespan funny enough. I actually liked DR David Sinclair before reading the book but at a certain point I felt a major brainwash coming and I was right, when he started talking about how safe GMO’s are and how amazing Bill Gates is he completely lost me. I understand to live naturally is hard or even impossible, but we all know the doggy things in studies published about GMO and withdrawn after heavy lobbying from GMO companies, or do we?
Funny enough even the University he is representing has fallen in my eyes, it makes sense now what sort of games they are playing and as always... money talks!

1 person found this helpful

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  • Jpat89
  • 30-06-2020

Fantastic

great book, if you are interested in longevity and the science behind it, read this!

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  • Santiago
  • 20-02-2020

Sound science

Really enjoyed the audiobook. David Sinclair is brilliant and opinionated. He is an authority in the science of aging, and can teach you what works to live longer and what is to come. Social/political issues discussed in the last section of the book may be a bit biased, but the discussion still was reasonable and relevant.

1 person found this helpful

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  • Anonymous User
  • 11-01-2020

Mind blowing

I loved it - a complete paradigm shit that may add decades of healthy life to your lifespan.

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  • A customer
  • 06-08-2020

Mind-expanding and hopeful

I loved this book. I loved it all the way through. I loved the way it explained and looked at this area of science from many different positions. Excellent.