Gavin is joined once again by Richard and Jessamy as they examine key developments in global health and science.

This week's discussion features reflections on the launch of a new Lancet series on Alzheimer’s disease, highlighting advances in prevention, diagnosis, and care, as well as the ethical and practical challenges posed by emerging treatments.

We also explore the global landscape of liver cancer, demographic change, the shifting centre of scientific research, and recent studies on human longevity. Join us for a thoughtful, evidence-based conversation on pressing issues in health, policy, and research worldwide.

Read the full series: https://www.thelancet.com/series-do/alzheimers-disease

Read the full commission: https://www.thelancet.com/commissions-do/hepatocellular-carcinoma

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Gavin welcomes Walter Willett, Shakuntala Thilsted and Johan Rockström to discuss the second EAT-Lancet Commission report. The co-chairs explain the significant updates since the inaugural 2019 commission, including new global evidence on nutrition, advances in food systems modelling, and a greater focus on equity and justice.

The panel addresses the health and environmental impacts of dietary choices, the urgent need for systemic transformation, and the practical challenges of achieving sustainable and healthy food for all. Walter, Shakuntala, and Johan provide an authoritative overview of why food justice, planetary boundaries, and community engagement are central to the future of both global health and the environment.

Read the Commission here:

https://www.thelancet.com/commissions-do/2025-EAT?dgcid=buzzsprout_tlv_podcast_lanceteat25_lancet

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Scientific research has traditionally treated the male body as the default, resulting in health inequity and poor outcomes for women in a world not designed for them. The Sex and Gender Equity in Research (SAGER) guidelines are an attempt to make sure research is designed for everyone, and that the outcomes better serve everyone.

Editor-in-chief of The Lancet Haematology Lan-Lan Smith and editor-in-chief of The Lancet Regional Health Americas Taissa Vila join Gavin to discuss how the history of scientific research led us to this point, what the SAGER guidelines are, and how science is addressing the research gap.

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Gavin, Richard, and Jessamy enter the studio once more for a Lancet Voice chat. A new book on Alzheimer's disease causes controversy across the Lancet team, we discuss the new Countdown on Plastics & Health, and a quick look at the problems facing the upcoming UN High Level Meeting on NCDs.

You can read the Lancet Countdown on health and plastics here:

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)01447-3/fulltext?dgcid=buzzsprout_tlv_podcast_August_25_lancet

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Where did the 10,000 steps recommendation come from? Why has it proven so stubborn? What's the science behind the new recommendations? How strong is the evidence?

Professor Melody Ding joins Gavin to talk about her new systematic review published in The Lancet Public Health, examining the relationship between step counts and health outcomes. We also explore the challenges of measuring physical activity, the importance of inclusive research, and the role of environmental and policy interventions in promoting population health.

Read the article from The Lancet Public Health here:

https://www.thelancet.com/journals/lanpub/article/PIIS2468-2667(25)00164-1/fulltext?dgcid=buzzsprout_tlv_podcast_August_25_lanpub

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It’s no exaggeration to say that the past decade has revolutionized how we think about and treat obesity. Drugs like semaglutide (Wegovy) and tirzepatide (Zepbound) have dominated headlines, enabling significant weight loss at speeds once considered unthinkable. The market for innovative weight loss medications is booming, with pharmaceutical companies investing heavily in hopes of developing the next blockbuster drug.

However, amid this race for market dominance, many experts are questioning whether the amount of weight loss alone is the best measure of these drugs’ usefulness. How can the next generation of obesity treatments meaningfully improve upon the powerful options already available?

Joining The Lancet editors Callam Davidson and Miriam Sabin to discuss this question is Professor Steven Heymsfield from the Pennington Biomedical Research Center. This wide-ranging conversation covers exciting pharmaceutical advances and limitations of these treatments, including the significant disparities in access, and why these breakthroughs may have broader societal implications.

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The sustainability of our existence relies on the health of every human, every animal, and the environment we all share. Published today, "The Lancet One Health Commission: harnessing our interconnectedness for equitable, sustainable, and healthy socioecological systems" highlights challenges like climate change, food security, and antimicrobial resistance to lay out the One Health approach to informing and implementing solutions.

Senior Executive Editor at The Lancet Pam Das is joined by lead Commissioners, Andrea Winkler and John Amuasi, to explain the past, present, and future of the One Health concept.

You can read the Commission here:

https://www.thelancet.com/commissions-do/one-health?dgcid=buzzsprout_tlv_podcast_lancetonehealth25_lancet

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Professor Adam Kucharski joins Gavin & Jessamy to discuss the intersection of mathematics, epidemiology, and truth, off the back of his new book, Proof. How do we generate scientific knowledge? How can we communicate uncertainty? What is the impact of social media and artificial intelligence on public trust in science?

Adam also tells us about the importance of public engagement, the nuances of misinformation, the importance of transparency in policy, the future of scientific communications, the need for adaptable definitions of proof, and the value of pragmatic, transparent approaches to decision-making in health and science.

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