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The Next 100 Days Podcast

The Next 100 Days Podcast

By: Kevin Appleby & Graham Arrowsmith
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 The Next 100 Days Podcast is a leading UK business show. Through this podcast, Kevin and Graham reveal strategies you can use to improve your business and take it to the next level. In addition to featuring their own advice, Kevin and Graham host amazing guests from across the business world. Often the guests are successful, but lesser-known business owners and entrepreneurs, enabling the show to bring fresh content and stand out from many of the US based business shows. Graham and Kevin believe that business change comes about when a business owner focusses on just one thing that will make a real difference to his business. That might be product development, a new product launch or a marketing campaign. Focussing for less than 100 days, or focussing on too many things generally won't deliver the results you need, Equally, its difficult to maintain effective focus for much longer than 100 days without re-assessing priorities. The Next 100 Days Podcast is your source to learn how to move your business forward, with practical advice and guidance that you can put into action and make a difference in your own organisation within the next 100 days.Copyright 2026 Kevin Appleby & Graham Arrowsmith Economics Leadership Management Management & Leadership Personal Finance
Episodes
  • #519 - Ed Cappabianca - Ingenion Medical

    #519 - Ed Cappabianca - Ingenion Medical
    Apr 3 2026
    Ingenion Medical, run by our guest Ed Cappabianca, is going to change the standard catheter in the UK - The Foley catheter. Urinary catheter-associated infections kill 2,100 people a year and block 1.2 million hospital bed-days. And yet, the Foley catheter - the standard of care - has barely changed in 91 years. Ingenion Medical has built what replaces it.The cymactive™ 2.0R is a CE-marked, patient-controlled urethral catheter with a patented magnetic valve that is already in clinical use across the UK and 15 international markets. It is superior to either standard Foleys or intermittent catheters, and generates revenue today. Ingenion Medical are seeking investors. Here's the Investment case:• Revenue generative, regulatory approved. CE Mark achieved Q1 2024. ISO 13485 renewed October 2025. FDA pre-sub meeting completed.• Commercial traction. Distributor agreements in over 10 countries. NHS Supply Chain at contract award stage. 15 NHS hospitals active or in pipeline.• Profitable at 1,600 patients per month (80 urologists x 20 patients). Breakeven H2 2027. £49m revenue projected 2030.• Exit precedent. Comparable urology acquisitions: Urotronic > Laborie $600m;Neotract > Teleflex $1.1b; Augmenix > Boston Scientific $600m; .• World-class advisors. Advisory board includes: Professor Chris Chapple (former European Association of Urology Secretary General) and Professor Kurt Naber, global authority on urinary tract infections.If you would like the detailed Investor Pitch Deck, go to: ingenion.approvedinvestors.co.ukSummary of PodcastKey TakeawaysThe Problem: Current catheters cause frequent, costly infections (£2k–£3.5k per cycle for the NHS) and severely limit patient mobility and quality of life.The Solution: Ingenion's cymactive catheter is a 30-day, self-voiding device with no external bag, restoring patient dignity and designed to reduce infection risk.Market Validation: The NHS created a new framework channel specifically for SimActive, signaling strong support for its innovation and cost-saving potential.The Ask: Ingenion is raising £2M (for ~10% equity) to fund commercialisation, targeting a future trade sale to a major urology firm for a potential 10x investor return.The Problem with Current CathetersUrinary Retention: A common condition caused by issues like BPH (enlarged prostate), Parkinson's, MS, and spinal cord injuries.Foley Catheter (Indwelling):The 100-year-old standard, anchored by an internal balloon.Creates a "superhighway for bacteria," causing frequent, costly infections.Full cost of ownership for the NHS is ~£800/month per patient.Intermittent Catheters (Single-Use):Used 5–8 times daily, creating significant waste and inconvenience.Account for 90% (£157.5M) of the NHS's £175M annual catheter spend.Patient Impact:Fear of infection and public voiding → social isolation.Reduced fluid intake → dehydration, which can worsen conditions like dementia.The cymactive SolutionInnovation: A 30-day, self-voiding catheter with no external tubes or bags.Mechanism:An internal, patient-controlled magnetic valve.An external magnet opens the valve; removing it allows the valve to close naturally.Infection Defense:The urethra seals over the valve's end, mimicking the body's natural defense against bacteria.Anecdotal evidence suggests reduced infections and restored function.Product Pipeline:Current: cymactive for male urinary retention (CE marked).In Development: Versions for women and for male incontinence.Market Validation & CommercialisationNHS Adoption:The NHS created a new framework channel for cymactive, as it didn't fit existing categories.Ingenion was the sole applicant and signed a 2-year contract on March 12, 2026.Ordering codes are now live for hospitals.Go-to-Market Strategy:Goal: Build awareness among clinicians and patient groups.Method: Target early adopters and use their case studies, shared by the NHS innovation team, to drive broader adoption.Rationale: A randomised control trial was unfeasible because Foley catheter users were unwilling to risk being randomised to the control group.Investment OpportunityThe Ask: £2M for ~10% equity (pre-money valuation: £18M).Exit Strategy: Trade sale to a major urology firm (e.g., Coloplast, Becton Dickinson).Rationale: Leverage a large firm's infrastructure for rapid, global scaling.Target Return: A typical venture capital return of ~10x investment.Investor Profile: High Net Worth (HNW) or Sophisticated Investors.Due Diligence: Pitch deck available at ingenion.approvedinvestors.co.ukThe Next 100 Days Podcast Co-HostsGraham ArrowsmithGraham founded Finely Fettled in 2014 to provide data from The UK High Net Worth Database to marketers targeting affluent and high-net-worth customers. He's the founder of MicroYES, a Partner for MeclabsAI, creating lead generation AI Agents & Workflows and introducing the MeclabsAI Platform. Graham also provides an Answer Engine Optimisation solution to get your website in shape to be found ...
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    1 hr
  • #518 Carmen Sederino - Illuminated Story

    #518 Carmen Sederino - Illuminated Story
    Mar 27 2026

    Carmen Sederino’s holistic approach to her Illuminated Story approach combines narrative structure, stage presence, and multimedia elements to create immersive, encore-worthy shows that resonate deeply with audiences. Drab speakers are a thing of the past!

    Summary of Podcast

    Introduction to Carmen and her background

    Graham introduces Carmen Sederino, who is joining the podcast from Australia. Carmen shares her background, including her formal training in theater and performing arts, as well as her extensive corporate experience leading marketing and branding teams.

    Carmen's approach to helping clients with presentations

    Carmen explains how she works with clients, often high-level executives, to transform their presentations and speaking skills. She focuses on crafting compelling stories and messages, as well as helping them develop their stage presence and delivery.

    Practical tips for improving presentations

    Carmen provides specific examples and techniques she uses to help clients, such as having them practice delivering content in different personas or styles to expand their range, and using pauses and energy to create more impact.

    Carmen's business and the power of storytelling

    Graham and Carmen discuss the "Illuminated Story" brand and Carmen's focus on helping clients illuminate their stories and expertise through engaging presentations. They touch on the importance of storytelling in business communication.

    Kevin's upcoming presentation challenge

    Kevin shares that he is working on a presentation on a dry topic (ethics and governance) and asks Carmen for advice on how to make it more engaging and impactful.

    The Next 100 Days Podcast Co-Hosts

    Graham Arrowsmith

    Graham founded Finely Fettled in 2014 to provide data from The UK High Net Worth Database to marketers targeting affluent and high-net-worth customers. He's the founder of MicroYES, a Partner for MeclabsAI, creating lead generation AI Agents & Workflows and introducing the MeclabsAI Platform. Graham also provides an Answer Engine Optimisation solution to get your website in shape to be found by LLMs.

    Kevin Appleby

    Kevin specialises in finance transformation and implementing business change. He's the COO of GrowCFO, which provides both community and CPD-accredited training designed to grow the next generation of finance leaders. You can find Kevin on LinkedIn and at kevinappleby.com
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    49 mins
  • #517 Adam O'Leary - Lead Generation

    #517 Adam O'Leary - Lead Generation
    Mar 20 2026
    This is a lead generation focused podcast about a novel B2B sales follow-up strategy.Summary of PodcastKey TakeawaysNovel Follow-Up Strategy: A third-party "good cop" provides hyper-relevant value (e.g., podcast intros) to prospects, bypassing their AI-filtered inboxes and achieving 70–80% reply rates.AI-Proofing Business: The strategy is designed to be AI-proof by focusing on human connection, a core element Adam believes AI cannot fully automate.AI's Primary Blocker: Kevin identified legacy systems as the main barrier to AI adoption in finance, not resistance to the technology itself.Podcast Book Opportunity: The podcast's 500+ episodes offer a rich source for an AI-assisted book, distilling key lessons and future-casting.The Problem: Ineffective Sales Follow-UpStandard "just checking in" emails are ineffective, especially with high-value prospects ($5M+ revenue) who use AI-powered inbox filters.These filters learn to ignore senders after 2–3 unanswered emails, causing messages to be routed to spam.Result: 66% of marketing-qualified leads are lost because they are not ready to buy immediately.The Solution: A "Good Cop" Follow-Up StrategyAdam's firm, SimpleWins.io, acts as a third-party "good cop" to maintain engagement with prospects outside the main sales cycle.Process:Web Listening: A team monitors public signals (news, podcasts, blogs) to identify a prospect's current, hyper-relevant goals.Value Delivery: The team offers non-sales-related value aligned with those goals (e.g., podcast intros, affiliate partnerships).Expert Positioning: The "good cop" builds a separate relationship, subtly reinforcing the client's expertise until the prospect is ready to buy.Result: This approach achieves 70–80% reply rates, far exceeding the typical 0–20% for standard sales emails.AI's Impact on Business & AutomationAdam's Perspective:AI will automate most administrative tasks, creating "super soldiers" who manage large pipelines with AI assistants.The core human element of understanding business needs will remain essential.Adam is in a "race" to automate his own business, noting AI reduced a software development task from 3 months to 14 minutes.Kevin's Perspective:The main barrier to AI adoption in finance is legacy systems, not human resistance.Integrating AI requires a major transformation, not a simple bolt-on.AI enables advanced capabilities like continuous, multi-scenario forecasting (e.g., Monte Carlo simulations) that are impractical for humans.The current focus in finance is on governance, data security, and fraud prevention. The Next 100 Days Podcast Co-HostsGraham ArrowsmithGraham founded Finely Fettled in 2014 to provide data from The UK High Net Worth Database to marketers targeting affluent and high-net-worth customers. He's the founder of MicroYES, a Partner for MeclabsAI, creating lead generation AI Agents & Workflows and introducing the MeclabsAI Platform. Graham also provides an Answer Engine Optimisation solution to get your website in shape to be found by LLMs.Kevin ApplebyKevin specialises in finance transformation and implementing business change. He's the COO of GrowCFO, which provides both community and CPD-accredited training designed to grow the next generation of finance leaders. You can find Kevin on LinkedIn and at kevinappleby.com
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    51 mins
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