What if we could build an AI that doesn't just answer questions, but makes fundamental scientific discoveries on its own? That's the mission of Future House, and in this episode, host Allison Duettmann sits down with its co-founder, Andrew White.

Andrew shares the incredible journey that led him from chemical engineering to the forefront of the AI for Science revolution. He gives us a look under the hood at Future House's flock of specialized AI agents, like Crow, Finch, and Owl, and reveals how they recently accomplished in just three weeks what could have taken years: identifying an existing drug as a potential new treatment for a common cause of blindness.

But the conversation doesn't stop at the successes. Andrew offers a sharp critique of the current methods for evaluating AI, explaining what’s wrong with benchmarks like "Humanity's Last Exam" and why the ultimate test is real-world discovery. He also makes a compelling case for completely reinventing the slow and inefficient scientific publishing system for an era where machines are both the producers and consumers of research.

On the Existential Hope Podcast hosts Allison Duettmann and Beatrice Erkers from the Foresight Institute invite scientists, founders, and philosophers for in-depth conversations on positive, high-tech futures.

Full transcript, listed resources, and more: https://www.existentialhope.com/podcasts

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What if the most desirable AI future is made of powerful tools, not autonomous agents? Physicist and futurist Anthony Aguirre joins us to unpack the Tool AI pathway, how incentives, liability, and design choices could steer us toward AI that empowers people rather than replaces them. We also situate this episode in AI Pathways, our two-scenario project exploring Tool AI and d/acc futures. Explore the project: https://ai-pathways.existentialhope.com/

On the Existential Hope Podcast hosts Allison Duettmann and Beatrice Erkers from the Foresight Institute invite scientists, founders, and philosophers for in-depth conversations on positive, high-tech futures.

Full transcript, listed resources, and more: https://www.existentialhope.com/podcasts

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Self-driving cars aren’t science fiction, they’re already here. But what kind of future are they steering us toward?

In this episode, Beatrice speaks with Andrew Miller, mobility expert and author of The End of Driving, about the transformational promise, and very real risks, of autonomous vehicles. They explore why driverless tech isn’t just about hardware or software, but about regulation, land use, curb management, jobs, and values.

From robo-taxis in San Francisco and driverless trucks in Texas, to curb chaos, job displacement, and how we reclaim space from parked cars, this episode goes far beyond the hype.

On the Existential Hope Podcast hosts Allison Duettmann and Beatrice Erkers from the Foresight Institute invite scientists, founders, and philosophers for in-depth conversations on positive, high-tech futures.

Full transcript, listed resources, and more: https://www.existentialhope.com/podcasts

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How do we shape a future worth rooting for?

In this episode, Beatrice Erkers talks with Jim O'Shaughnessy, founder of O'Shaughnessy Ventures and author of What Works on Wall Street, about his third act: backing creators, thinkers, and innovators across publishing, film, AI, and investment. They dive into the cultural power of storytelling, what it means to be “AI-first,” and why cognitive diversity and personal agency are key to navigating a rapidly changing world.

Jim shares his existential hope for the next 30 years, explores how to make AI work for everyone, and offers a call to action for people with ideas: get in the arena. Along the way, we cover self-driving cars, tutoring AIs, philosophical simulations, and why beautiful books still matter.

On the Existential Hope Podcast hosts Allison Duettmann and Beatrice Erkers from the Foresight Institute invite scientists, founders, and philosophers for in-depth conversations on positive, high-tech futures.

Full transcript, listed resources, and more: https://www.existentialhope.com/podcasts

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How do we imagine, validate, and steer toward better futures?

In this conversation, scientist and writer Michael Nielsen joins Beatrice Erkers to explore the idea of “hyper-entities”, future artifacts that reshape our capabilities and the verbs we use to describe them. They discuss how science fiction, public goods mechanisms, and open science feed into real-world innovation, and how imagination and design shape the trajectory of civilization.

Michael reflects on dual-use technologies, from quantum physics to cryptography, and explains why deep truths about the universe often come bundled with both promise and peril. They also dive into "tools for thought," kindness as a moral technology, and why exploration, however illegible, is crucial for progress.‍

On the Existential Hope Podcast hosts Allison Duettmann and Beatrice Erkers from the Foresight Institute invite scientists, founders, and philosophers for in-depth conversations on positive, high-tech futures.

Full transcript, listed resources, and more: https://www.existentialhope.com/podcasts

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What if the bulky, expensive machines that fill hospital radiology departments could be replaced by a wearable? In this episode, we speak with Mary Lou Jepsen — founder of Openwater and pioneering inventor — about how breakthroughs in light-based imaging could democratize access to brain and body scans.

From her work at Google X and Facebook’s moonshot labs to her current mission at Openwater, Jepsen has spent decades at the frontier of tech and health. Now, she’s building a future where scanning the body for disease is as simple as putting on a hat — no radiation, no giant machines, no $1M price tag.

We explore:

• Why light could be the key to affordable, real-time medical diagnostics
• How her device works — and what it might replace
• What it takes to challenge the medical-industrial complex
• Her vision for global healthcare access and early detection

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On the Existential Hope Podcast hosts Allison Duettmann and Beatrice Erkers from the Foresight Institute invite scientists, founders, and philosophers for in-depth conversations on positive, high-tech futures.

Full transcript, listed resources, and more: https://www.existentialhope.com/podcasts

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In this episode of the Existential Hope Podcast, Ed Finn, founding director of ASU’s Center for Science and the Imagination, explores the impact of storytelling on our ability to envision and create better futures—and why we urgently need more hopeful narratives.

Ed shares his journey from a generalist interested in how technology shapes culture to co-creating initiatives like "Project Hieroglyph" with celebrated sci-fi author Neal Stephenson. He argues that our collective imagination is often stuck in dystopian loops or unable to escape the status quo, hindering our capacity for large-scale, positive change. By bringing together storytellers, scientists, and artists, we can craft "technically grounded, hopeful stories about futures we might actually want to live in."

In this conversation, we explore:

• The fundamental role of imagination and narrative in how we understand the world, make decisions, and even perceive reality.
• Why science fiction can be a powerful tool for foresight, societal deliberation, and inspiring innovation (the "hieroglyph" concept).
• The importance of moving beyond easy apocalypses to explore "protopian" futures where things are actively getting better, and the challenge of crafting compelling narratives of social change.
• How reflecting on classic tales like Frankenstein can inform our approach to scientific creativity, responsibility, and the societal implications of new technologies like AI.
• The potential resurgence of the humanities in an AI-driven world and why critical thinking and a rich self-imagination are crucial for collaborating with new technologies.

On the Existential Hope Podcast hosts Allison Duettmann and Beatrice Erkers from the Foresight Institute invite scientists, founders, and philosophers for in-depth conversations on positive, high-tech futures.

Full transcript, listed resources, and more: https://www.existentialhope.com/podcasts

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In this episode of the Existential Hope Podcast, Niklas Berild Lundblad, a philosopher, researcher, and former policy lead at Google DeepMind, Google, and Stripe, explores the interplay between progress, complexity, and the transformative potential of artificial intelligence.

Niklas discusses why asking the right questions is crucial for navigating our future, especially as AI challenges our self-perception and introduces new forms of complexity. He discusses the "soft narcissism" in AI development, the distinction between AI and AGI, and why we should view current AI not as a mirror, but as a strange, exotic artifact whose full capabilities we are still underestimating.

In this conversation, we explore:

• The critical relationship between progress and complexity, and why managing this dynamic is essential for societal growth (including the "Red Queen effect").
• Why current AI developments feel different from past tech hypes.
• The potential for AI to revolutionize scientific discovery.
• How AI could accelerate its own diffusion.
• The need for curious regulators, mechanisms for change, the challenges of agentic AI, and how cultural biases might affect our approaches to regulation.
• The Solow Paradox and the Gartner Hype Cycle as frameworks for understanding technology adoption.

On the Existential Hope Podcast hosts Allison Duettmann and Beatrice Erkers from the Foresight Institute invite scientists, founders, and philosophers for in-depth conversations on positive, high-tech futures.

Full transcript, listed resources, and more: https://www.existentialhope.com/podcasts

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Hosted on Acast. See acast.com/privacy for more information.