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In this empowering episode, Dr. Gabrielle Lyon sits down with the incredible mother-daughter duo, Michelle and Joan MacDonald, to share the blueprint for radical physical transformation at any age. Joan, who began her journey nearing 71 years old, proves it's never too late, while coach Michelle, a Certified Strength and Conditioning Specialist (CSCS), cuts through the noise on training, nutrition, and mindset.

They tackle deeply personal topics, including Michelle's 15-year struggle with a severe eating disorder and the shame that surrounds women's health. This is a must-watch to learn the non-negotiable pillars for building a strong, resilient, and healthy body, no matter your starting point.

Michelle MacDonald is a trailblazer in the global movement to redefine aging and female

empowerment through strength. As the founder of The Wonderwomen, a world-class coaching

brand built on her signature methodology, The Fitness Model Blueprint™, Michelle has

transformed thousands of women—inside and out—with evidence-based strategies that merge

mindset, muscle, and metabolic mastery.

Joan MacDonald (Fitness Icon and Mother)

At 70, Joan MacDonald was getting winded walking up a flight of stairs and now, at 74, she is doing weighted pull-ups and 200 lb hip thrusts.

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Chapters:

0:00 - The ED Crisis: Michelle’s 15-Year Battle & Recovery

2:04 - Joan Started Lifting at 71: Debunking the Age Myth

6:16 - Pillars of Transformation: Mindset, Sleep, Food

8:52 - Finding Your "Why": Aesthetics vs. Longevity

12:01 - Why Strength Training Must Come First

14:28 - Grittiness: The Secret to Joan's Radical Success

24:54 - Hard Truths: The "Nursing Home" Speech That Changed Joan's Life

26:47 - The Transformation Container: Non-Negotiables for Success

47:03 - Disordered Eating: When to Get Expert Therapy vs. Coaching

50:11 - GLP-1s and the "Food Noise" Solution

58:12 - 3 Essential Beginner Exercises (Joan's Choices)

1:04:22 - Strength Goals: The 3 Exercises a Strong 40-Year-Old Must Master

1:10:29 - The Hip Thrust: #1 Glute Builder and Muscle Mandate

1:14:09 - Training is a Skill: How to Prevent Injury

1:19:11 - Core Strength: Why Glutes and Abs Prevent Falls

1:33:37 - Training the Individual: Why Age Doesn't Matter

1:37:29 - Nutrition Blueprint: Protein First for Satiety and Adherence

Find Michelle at:

https://www.instagram.com/yourhealthyhedonista/

http://MichelleMacdonaldOfficial.com

Podcast: https://podcasts.apple.com/us/podcast/the-wonder-women-official/id1677831398

Find Joan at:

https://www.instagram.com/trainwithjoan

https://www.trainwithjoanofficial.com

Find Dr. Gabrielle Lyon at:

- Instagram:@drgabriellelyon

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In this compilation episode, Dr. Gabrielle Lyon is joined by the top experts in Testosterone and men's health treatments.

You'll learn:

- The Testosterone Truth: Why aging alone doesn't drop T levels and why acquisition of conditions like obesity is the real culprit.

- The Numbers Game: Why the standard "low T" cutoff is misleading and why you must check your Free Testosterone.

- ED as a Warning: How erectile dysfunction is a sensitive marker of overall health and heart risk.

- Treatment Protocols: The efficacy of Cialis/Viagra for both erections and cardiac protection, and the risks of unchecked influencer advice on steroids.

- Lifestyle Power: The direct link between muscle mass, exercise, and sexual function—and why the penis is the "first to go" when overall health declines.

----------

Chapter Markers

0:00 - Testosterone is a Brain Hormone

0:40 - Debunking the Myth: Male Menopause (Andropause) Doesn't Exist

1:33 - The Dangers of Unchecked Influencer Advice on Testosterone

3:07 - Defining Testosterone Deficiency: Symptoms vs. Signs

5:10 - The Arbitrary Number: Why Guidelines Disagree on Low T

8:29 - Free Testosterone: The Most Reliable Indicator of Male Health

15:28 - TRT vs. Steroids: Defining the Line and Risks

18:59 - The Real Risks of TRT: Infertility and Hematocrit

22:36 - The Shocking Backstory: Challenging the Prostate Cancer Myth

26:40 - Erectile Dysfunction (ED) and Lifestyle Modification

29:21 - Shockwave Therapy for ED: The Science and the Cash Business

33:53 - Penile Tissue Atrophy and Venous Leak

37:25 - The Role of Muscle Mass, Sarcopenia, and Sexual Function

39:41 - The Single Best Marker for Male Health: Erectile Function

42:02 - The Science of Cialis and Viagra (PDE5 Inhibitors)

45:49 - The Viagra Story: From Heart Drug to ED Cure

50:50 - Tadalafil (Cialis) as a Triple-Threat Drug (Cardiac, Urinary, Sexual)

53:57 - The Role of Testosterone in Female Sexual Function

55:20 - Hypogonadism: Diagnosis, Treatment, and Fertility Risk

Dr. Abraham Morgentaler is an Associate Clinical Professor of Urology at Harvard Medical School and founder of Men's Health Boston. He is an internationally recognized expert in men's health, particularly known for his pioneering work in testosterone therapy. Dr. Morgentaler is credited with reversing the long-held belief that testosterone therapy causes prostate cancer and is the author of several books on men's health.

Dr. Kohler is the co-founder of the Erectile Restoration Outcomes Study (EROS) penile implant registry. In addition to his clinical and research activities, Dr. Kohler is active in education, providing mentorship to residents and fellows.

Dr. Mo Khera is Mohit Khera, M.D., M.B.A., M.P.H., a urologist and professor at Baylor College of Medicine. He is an expert in male and female sexual dysfunction and testosterone replacement therapy, and his work focuses on male infertility, sexual dysfunction, and declining testosterone levels. He is also the President of the Sexual Medicine Society of North America.

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Disclaimer: The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health...

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In this fascinating episode, Dr. Gabrielle Lyon talks with neuroscientist Dr. Ben Rein, PhD (author of Why Brains Need Friends), about the science of social connection, emotion, and cognitive health. Dr. Rein, an expert in neurobiology and psychedelic research, reveals the cutting-edge studies that explain why loneliness is as damaging as smoking and how our digital world is affecting our brain's ability to connect.

They discuss the neurochemistry of love, the controversial use of MDMA in therapy, and whether AI can ever truly replace human intimacy. This conversation provides an essential look at the biological drivers of happiness, performance, and long-term brain health.

Chapter Markers:

0:00 - MDMA (Molly): The History & Therapeutic Benefits

5:59 - The Legal Status of MDMA for PTSD

6:44 - The Safety and Effectiveness of MDMA in Clinical Trials

8:29 - PTSD (The Amygdala Alarm)

9:41 - How MDMA Soothes the Amygdala to Access Memory

11:42 - Is There an Alternative to MDMA? (Ketamine's Mechanism)

13:16 - Ketamine and Neuroplasticity for Depression

15:48 - Botox and Empathy:

18:12 - The Problem of Volume: How Screens Depersonalize Interaction

19:48 - The Virtual Disengagement Hypothesis Explained

25:00 - Defining Cognitive and Emotional Empathy

29:43 - MDMA's Link to Serotonin & Social Reward

31:04 - Do SSRIs Have Pro-Social Effects?

36:10 - The Science of Likability and "Easy to Read" Faces

40:10 - Top 3 Ways to Be More Likable

49:49 - The Likability Gap: Why You Underestimate How Well-Liked You Are

56:59 - The Neurobiology of Oxytocin, Dopamine, and Serotonin

1:09:23 - The Goldilocks Zone of Empathy

1:15:58 - Narcolepsy

1:18:16 - Alcohol: Why the Neurotoxin is Bad for Brain Health

1:21:47 - Exercise and Neurogenesis

1:22:27 - Sex, Orgasm, and Oxytocin Release

1:25:06 - Oxytocin During Childbirth

Who is Ben Rein:

Dr. Ben Rein is an award-winning neuroscientist and Chief Science Officer of the Mind Science Foundation, where he supports early-career researchers in neuroscience. He earned his PhD from SUNY Buffalo and completed postdoctoral training at Stanford University, publishing over 20 peer-reviewed papers on autism, empathy, MDMA, and digital behavior. Recognized by the NIH, the Society for Neuroscience, and Sigma Xi, he also serves as a scientific advisor to more than 20 organizations. With over one million followers and 75 million video views, Dr. Rein is celebrated for making neuroscience accessible to the public and has been featured by outlets such as Good Morning America, ABC News, and PopularMechanics.

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In this explosive episode, Dr. Gabrielle Lyon sits down with relationship expert Marianne Brandon to confront the modern crisis of intimacy and sexual wellness. They dive into how the digital world—including porn, AI companions, and VR technology—is creating an evolutionary mismatch that clashes with our primal needs for bonding, leading to rising loneliness and sexual dysfunction.

Dr. Lyon and Marianne Brandon explore the science behind what truly impacts performance, from erectile dysfunction (ED) and hormonal imbalances to the neurological effects of stress. This is a must-watch for couples, parents, and anyone navigating romance in the digital age.

----------

Chapter Markers

0:00 - Intro

0:49 - The Primal Need for Sex vs. The Digital World

1:10 - The Hidden Cause of Erectile Dysfunction (ED)

2:10 - The Loneliness Crisis: Gen Z, AI, and Intimacy

3:50 - Do Women and Men Experience Desire Differently?

5:15 - Stress is the #1 Libido Killer

6:30 - Porn and AI: Is Sexting with a Bot Cheating?

8:05 - The Surprising Impact of VR Porn on Sperm Quality

9:30 - Action Plan: The #1 Move to Improve Your Sex Life Today

Who is Marianne Brandon:

Dr. Marianne Brandon is a licensed clinical psychologist and a diplomate in sex therapy, recognized for her expertise in technologies impact on intimacy, evolutionary influences on human sexuality, and cultivating a more exciting sexual connection in long-term relationships. Dr. Brandon is best known for her forward-thinking work on the future of intimacy through blogging, lecturing, and podcasting. Her popular Psychology Today blog, “The Future of Intimacy,” explores emerging trends in technology and human connection. As a continuing education provider, she lectures on sex tech’s impact on intimacy as well as the impact of technology on humanity. Together with her husband, urologist Dr. Abraham Morgentaler, she co-hosts the podcast “The Sex Doctors,” bringing expert insight and candid dialogue to listeners on all aspects of sex, relationships, and technology’s transformative role in our lives. Drawing from nearly three decades of clinical experience, she offers psychotherapy focused on relationship issues and sexual concerns, with a reputation for blending clinical skill and compassionate care.

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• Website: https://www.drbrandon.net/
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• X (Twitter): x.com/drgabriellelyon
• Apply to become a...

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In this episode, Dr. Gabrielle Lyon sits down with Dr. Heidi van den Brink; one of the only scientists in the world studying the ovarian transition from fertility to menopause. Together, they unpack what textbooks and wellness influencers often miss: the biology behind how your ovaries, uterus, metabolism, and nutrition interact across every stage of a woman’s life.

Dr. Heidi reveals the never-before-seen dynamics of the ovarian cycle, how follicles develop in “waves,” and what really happens during the menopause transition. They discuss how undernutrition, obesity, and metabolic health shape reproductive hormones; why early menarche and delayed ovulation matter for long-term health; and the surprising connection between your gut microbiome, bile acids, and fertility.

If you’ve ever been told to “balance your hormones” with seed cycling, apps, or supplements, this episode separates myths from mechanisms. It’s a masterclass in understanding the science of your hormones and how to truly support reproductive health through every decade of life.

Chapter Markers

0:00 - Can You Get Pregnant While on Your Period?

1:21 - Intro to Dr. Heidi & Ovarian Cycle Research

3:39 - The Uterine Cycle vs. The Ovarian Cycle

6:19 - Follicle Waves: The Hidden Drama in Your Ovaries

10:38 - Novel Discovery: Follicle Waves in the Luteal Phase

12:00 - Why One Follicle is Selected for Ovulation

13:17 - Does Nutrition Affect Ovarian Function?

14:48 - The Variation in Menstrual Cycles (It's Not Always 28 Days)

17:23 - The Impact of Obesity on the Ovarian Cycle

18:11 - The Problem of Luteal Phase Defects & Fertility

24:52 - Ovarian Morphology as a Bio-Marker of Health

26:54 - How Undernutrition Affects Ovarian Health

31:56 - The Metabolic Tipping Point of PCOS (Polycystic Ovary Syndrome)

33:26 - The Myth of the "String of Pearls" Ovary

35:25 - The Menopause Transition & Rogue Follicles

39:04 - Can We Predict Menopause by Scanning Ovaries?

45:59 - Early Menarche (First Period) and Long-Term Disease Risk

48:33 - The Surprising Link Between Puberty Timing and Environment

52:28 - The Role of Leptin in Reproductive Health

55:50 - Debunking the Myth: Can Nutrition Cure PCOS?

59:07 - PCOS Diet Myths (Fruit, Timing, and Supplements)

1:04:40 - Fish Oil for Menstrual Cramps (Dysmenorrhea)

1:08:37 - Breakthrough: Bile Acid, The Gut Microbiome, and Ovulation

1:11:50 - Closing Remarks

Who is Heidi Vanden Brink:

Dr. Vanden Brink is a reproductive physiologist with over a decade of research in nutrition, metabolism, and female reproductive health. Her work focuses on how diet and metabolic conditions like obesity influence reproductive development during adolescence, with the goal of preventing disorders such as PCOS.

Find Heidi Vanden Brink at:

• Texas A&M University: https://nutrition.tamu.edu/people/vanden-brink-heidi/
• Google Scholar:

In this highly requested AMA, Dr. Gabrielle Lyon addresses the most critical questions surrounding male hormone health. Dr. Lyon tackles the fear, stigma, and misinformation surrounding Testosterone Replacement Therapy (TRT), revealing why a low testosterone level is a major predictor of serious health issues like heart disease, bone fracture, and obesity.

She breaks down the current medical consensus on TRT, the risks of replacement, the truth about dosing, and what every man over 40 needs to know about their hormone health. This is a must-watch to separate the bodybuilding myths from the medical facts.

Chapter Markers

0:00 - Intro: Low Testosterone is a Predictor of Heart Disease

1:12 - The Penile Shrinking Myth: What Caused the Viral Frenzy

2:20 - Testosterone Levels: The Truth About Aging in Men

3:44 - The First Step: What Labs to Ask Your Doctor for

4:22 - Why Men Need to Check Their Estrogen (Estradiol)

6:13 - The Medical Cutoff for Low T and Androgen Sensitivity

7:27 - Low T is Linked to Fatigue, Depression, and Fat Deposition

9:27 - TRT and Cardiovascular Health: Is it Protective or a Risk?

10:36 - Erectile Dysfunction Predicts Heart Attack Within 3-5 Years

12:30 - The Stigma: Why Doctors Don't Check Testosterone

13:00 - TRT vs. Steroids: Defining the Line

14:21 - Infertility and TRT: What You Must Know

15:18 - Safety: What are the Risks of TRT for Men?

16:33 - The Stigma: Why Doctors Don't Treat Low T

17:15 - TRT and Obesity: Treat Concurrently or Wait?

18:10 - Menopause vs. Andropause: Why Men Don't Have to Decline

19:34 - Testosterone Boosters (Ashwagandha, Tongkat Ali)

26:11 - Different Forms of Testosterone Administration

28:09 - Intranasal Testosterone for Less Impact on Fertility

30:38 - Managing Expectations: How Long Until You Feel Better?

33:00 - TRT and Muscle Gain: The Highs and Lows of Dosing

36:47 - The Win-Win: Low Risk, High Reward

39:00 - Blood Flow & Erectile Function: Cialis and Exercise

40:17 - Semen Quality as a Marker for Overall Male Health

41:29 - Parenting and the Cost of Unhealthy Humans

41:45 - How to Raise Testosterone Naturally (The Pillars)

42:29 - Low-Dose Cialis for Cardiovascular Health (Preemptive Strategy)

43:59 - Dr. Lyon's TRT Journey and Early Concerns

46:00 - Outro

Key Takeaways:

• Low Testosterone is a major health risk. Low T is linked to an increased risk of bone fracture, heart disease, obesity, and diabetes.
• TRT is often protective. Contrary to the long-standing myth, replacing low testosterone to a healthy range does not increase the risk of cardiac events. It is, in fact, protective against cardiovascular disease.
• Erectile Dysfunction (ED) is a canary in the coal mine. ED can predict a heart attack within 3 to 5 years.
• Men can maintain high T levels. Testosterone levels in a healthy 75-year-old can be just as good as in a man in his 20s.
• The solution is often concurrent. For an obese or overweight man with low T, concurrent treatment with TRT and a lifestyle intervention is often the most responsible approach to provide the motivation needed for weight loss.
• Low-dose daily Cialis (2.5mg to 5mg) may be a viable preemptive strategy for cardiovascular health due to its blood flow benefits.

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In this powerful episode, Dr. Gabrielle Lyon sits down with legendary sales expert and entrepreneur Jeremy Miner to discuss the foundation of success. Jeremy, the founder of Seventh Level, reveals the mental frameworks, communication skills, and commitment required to achieve peak performance in any area of life.

Drawing from his own harrowing health scare and decades of experience coaching top performers, Jeremy shares candid insights into what separates the top 1% from everyone else. This conversation is not just about sales—it’s about the psychology of human connection, overcoming fear, and unlocking your full potential to build a more resilient and successful life.

Who is Jeremy Miner:

Jeremy Miner is an internationally recognized sales trainer and entrepreneur, best known as the founder of the sales training company 7th Level. He is the creator of the Neuro-Persuasion Sales Method and has a background in behavioral science, which he uses to train sales professionals. Previously, he was a highly successful, commission-only salesperson who was ranked among the top earners globally before retiring to start his training company.

Timestamps:

0:00 - Intro

3:06 - The Psychology of Success

10:31 - How Fear Can Drive You

14:40 - Communication Skills

33:14 - The Power of Problem-Finding

39:33 - The 4 Categories of Performance

1:00:21 - Jeremy’s Cancer Scare

1:12:32 - Advice for Mental Toughness

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Find Jeremy Miner at:

• Tiktok: https://www.tiktok.com/@jeremy_miner)
• Instagram: https://www.instagram.com/jeremyleeminer/)
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When you hear the word “radiation,” do you think of cancer, Chernobyl, or an airport scanner? In this powerful episode, Dr. Gabrielle Lyon sits down with Dr. Sanjay Mehta, a radiation oncologist, to completely redefine your understanding of radiation as a tool for medicine.

Dr. Mehta reveals how modern technology has made radiation oncology incredibly precise, minimizing side effects for cancer patients. He also shares groundbreaking insights into the underutilized field of low-dose radiation therapy, a safe and effective treatment for common inflammatory conditions like arthritis, tendinitis, and plantar fasciitis. This conversation is a must-watch for anyone with chronic pain or a fear of radiation, offering a new path to health and healing.

Chapter Markers

0:00 - Intro

0:42 - The biggest myths about radiation

1:33 - Dr. Sanjay Mheta's introduction

2:07 - Radiation as a treatment for prostate cancer

3:41 - The side effects of surgery vs. radiation

4:32 - The training of a radiation oncologist

5:34 - Full-body scans and diagnosis

7:48 - What is radiation?

9:00 - The difference between medicine and poison

10:50 - The electromagnetic spectrum

12:21 - Ionizing vs. Non-ionizing radiation

13:42 - How we are naturally exposed to radiation

15:50 - The biggest myth about radiation

18:50 - Hormesis and low-dose radiation

21:10 - The evolution of radiation technology

22:38 - Radiation in daily life (dentist X-rays)

25:00 - Can all cancers be destroyed by radiation?

26:43 - Why radiation doesn't always burn skin

28:25 - How radiation treatment is planned

32:27 - Side effects of prostate cancer surgery

33:09 - Penile shortening and prostate surgery

36:00 - The role of testosterone in prostate cancer

38:37 - How radiation affects bodybuilders

39:09 - Who is not a candidate for radiation?

41:33 - Is radiation the standard of care for all cancers?

42:32 - Debunking radiation fear (microwaves, etc.)

44:38 - The airport scanner debate

47:03 - Other sources of radiation exposure

52:32 - Grounding and radiation

54:40 - Low-dose radiation for musculoskeletal injuries

55:50 - The history of low-dose radiation

57:22 - The use of radiation in the 1800s

59:42 - Cortisone vs. low-dose radiation for pain

1:03:00 - Dr. Ma's personal story of treatment

1:04:07 - The duration and protocol of low-dose radiation

1:08:16 - Inflammation and low-dose radiation

1:10:59 - The durability of radiation therapy

1:12:00 - Reversal of disease

1:17:22 - Radiation's effect on hip pain

1:18:29 - Treating rheumatoid arthritis

1:20:29 - Post-operative radiation

1:22:11 - Low-dose radiation for Peyronie's disease

1:24:42 - What's holding back adoption of this therapy in the US?

1:26:45 - The future of low-dose radiation

1:27:31 - How to book an appointment with Dr. Mehta

1:28:09 - Closing Remarks

Who is Dr. Sanjay Mehta?

Dr. Sanjay Mehta has been treating cancer patients for over 25 years using state of the art radiation oncology technology. He is now successfully treating patients with arthritis, tendonitis, and plantar fasciitis with low dose radiation using proven European regimens. It is non invasive, painless, and covered by Medicare and most insurance plans.

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