In this informative episode of the Cardiovascular Matters podcast, host Dr. Craig Walker sits down with his colleague Terry Roberts to discuss pulmonary embolisms (PEs) in comprehensive detail. PEs, which occur when blood clots travel to the lungs, are a serious cardiovascular condition that can quickly become life-threatening if not properly diagnosed and treated.

Dr. Walker begins by explaining what a PE is on a physiological level, noting how clots blocking blood flow in the lungs can strain the heart and prevent oxygenation of blood throughout the body. He discusses how PEs originate as clots elsewhere in the body, most commonly the legs, that break off and travel to the lungs. Depending on their size, PEs can range from causing minor breathing issues to sudden cardiac arrest.

The discussion then delves into risk factors for developing PEs. Genetic hypercoagulable conditions that cause easier clotting are highlighted, as are external risk factors like smoking, prolonged immobility, recent surgery or trauma, and certain cancers. Dr. Walker stresses the importance of prophylactic measures for at-risk patients, such as compression stockings and blood thinners.

Some key points:

• PEs are the second leading cause of death from cardiovascular disease and can be fatal if large clots block oxygen from circulating in the blood.
• Risk factors for PEs include hypercoagulability, injury, prolonged immobility, surgery, cancer and smoking.
• Symptoms include shortness of breath, arrhythmias, and potentially sudden death from large clots.
• Diagnosis involves imaging tests like CT scans to detect clots in the lungs.
• Traditional treatments include blood thinners like heparin to prevent further clotting.
• Newer options like thrombolytic drugs and thrombectomy devices can dissolve or remove clots quickly in severe cases.
• Emergency support like ECMO can oxygenate the blood while clots are addressed.

Turning to diagnosis, imaging tests like CT scans that can detect clots in the pulmonary arteries are outlined. Dr. Walker also notes newer diagnostic guidelines that help physicians determine the likelihood a patient is experiencing a PE. Traditional first-line treatments involving blood thinners are explained, along with their limitations in dissolving large clots.

The bulk of the conversation focuses on recent advances in PE treatment. Dr. Walker enthusiastically discusses thrombolytic drugs that break down clots, endovascular thrombectomy devices that physically remove clots, and emergency circulatory support like ECMO. He shares inspiring case studies of how these interventions have saved critically ill patients within minutes of their arrival. The risks of these procedures are also addressed.

Overall, this podcast episode is an invaluable resource for anyone seeking to learn more about pulmonary embolisms, from causes and symptoms to state-of-the-art diagnosis and life-saving therapies. Dr. Walker's expertise and passion for the topic shine through, making complex cardiovascular science easy to understand.

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