College football Week 2 is here, and we’re breaking down the 10 biggest games of 2025 with picks, odds, and analysis. From Michigan–Oklahoma in Norman to Ole Miss–Kentucky in Kroger Field, it’s a loaded slate with rivalry spice and upset alerts.

We cover:

• 1:11 Michigan at Oklahoma – Wolverines’ front vs Sooners’ firepower, Bryce Underwood’s first true road test
• 4:34 USF at Florida – Golesh’s tempo vs Gators’ trench edge, look-ahead factor with LSU on deck?
• 7:52 Kansas at Missouri – Border War returns, Jalen Daniels vs Kirby Moore’s balanced Tigers
• 11:45 Iowa at Iowa State – Cy-Hawk trends, trench advantages and the perennial under
• 14:49 Illinois at Duke – Manny Diaz’s pressure packages vs Bielema’s ground game, sneaky talent edge for Duke
• 19:57 Arizona State at Mississippi State – Shapen healthy, Starkville at night, mirror rosters and key explosives
• 23:27 SMU vs Baylor – Lashlee vs Spavitol shootout potential, trench and pace edges at Ford Stadium
• 27:25 Boston College at Michigan State – Slow grind, coin-flip profile favors the points
• 31:08 Oklahoma State at Oregon – Ducks’ dominance vs Gundy’s road dog magic, is 28 too many?
• 34:41 Ole Miss at Kentucky – Stoops’ defense vs Kiffin’s tempo, series always tight in Lexington

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