College football Week 1 is here, and we’re breaking down the 10 biggest games of 2025 with picks, odds, and analysis. From Texas vs Ohio State in the Horseshoe to Clemson vs LSU in the Battle of the Death Valleys, it’s a stacked opening weekend.

We cover:

• 1:02 Ohio State vs Texas – Arch Manning’s chance against Ryan Day’s Buckeyes
• 6:17 Clemson vs LSU – Cade Klubnik vs Garrett Nussmeier, huge trenches battle
• 11:51 Miami vs Notre Dame – Carson Beck leads the Canes against Irish QB inexperience
• 17:00 Auburn vs Baylor – Hugh Freeze’s offense vs Dave Aranda’s Bears
• 21:49 Nebraska vs Cincinnati – Cornhusker takeover at Arrowhead
• 26:18 Alabama vs Florida State – Gus Malzahn debut, Thomas Castellanos vs Bama’s D
• 32:56 Colorado vs Georgia Tech – Coach Prime’s Buffs try to defend Boulder
• 36:46 South Carolina vs Virginia Tech – The Beamer Bowl
• 42:02 TCU vs North Carolina – Sonny Dykes vs Bill Belichick in Chapel Hill
• 46:32 Tennessee vs Syracuse – Vols’ depth too much for the Orange

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