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When traditional dewormers fail against resistant hookworms, veterinarians may turn to emodepside as a last resort. But are all formulations created equal? Not according to recently published research.

Join us as Theresa Quintana and Drs. Jeba Jesudoss Chelladurai and Stephanie Martinez reveal critical findings about bioequivalence between different emodepside formulations. Their research demonstrates that the feline topical formulation, when given orally to dogs at 3 mg/kg, produces approximately three times higher peak concentrations and 2.4-2.8 times greater systemic exposure compared to the EU canine modified-release tablet at the same dose.

These findings carry significant clinical implications, particularly for dogs with MDR1 mutations lacking P-glycoprotein transport mechanisms. Without this protective system, emodepside can accumulate in the brain and cause neurotoxicity. The research team guides us through proper diagnostic confirmation of resistant hookworms, recommended treatment approaches, and crucial safety considerations before turning to this last-line therapy.

The conversation expands into formulation differences, bioavailability challenges, and practical clinical protocols. Teresa, Jeba, and Stephanie emphasize that clients must follow strict fasting guidelines before and after administration, as food dramatically enhances emodepside absorption and could potentially lead to toxicity with the already higher-concentration feline product.

Whether you're dealing with suspected resistant hookworms in your practice or simply want to understand the science behind bioequivalence and drug safety, this episode provides essential knowledge for evidence-based clinical decision-making. This episode centers around the intersection of parasitology, pharmacology, and clinical medicine and highlights why the details matter when it comes to drug formulations and routes of administration.

AJVR article: https://doi.org/10.2460/ajvr.25.01.0027

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The simple ice pack - a staple in both human and veterinary medicine for reducing pain and swelling. But what if this common therapy has unexpected consequences for healing? Soft tissue surgeon Dr. Vanna Dickerson and veterinary student Gabriella Hansen join us to discuss their fascinating research on how ice packs affect blood flow in canine skin.

For years, surgeons have cautioned against using ice after delicate skin procedures like flaps and grafts, believing it might compromise blood flow. However, this advice lacked scientific backing until now. Through precise measurements using laser speckle contrast imaging, Dr. Dickerson and Hansen discovered that ice application reduces skin perfusion by 10-15% compared to baseline - and surprisingly, in some dogs, blood flow remained decreased even 15 minutes after the ice was removed.

This groundbreaking work confirms what many surgeons suspected but couldn't prove, giving veterinarians evidence-based guidance for post-operative care decisions. Dr. Dickerson and Hansen emphasize that ice remains valuable for pain control in most situations, but surgeons should exercise caution in cases where even small perfusion decreases could jeopardize healing. For pet owners, understanding these nuances helps explain why your veterinarian might specifically recommend for or against icing in different scenarios.

Beyond the clinical findings, Dr. Dickerson and Hansen offer valuable insights for veterinary students interested in research, encouraging them to find mentors and emphasizing that meaningful studies don't require complex laboratory setups. Their work exemplifies how asking simple questions about everyday practices can lead to significant improvements in patient care. Listen now to discover how this common therapy affects your pet's healing and what questions still remain for future investigation.

AJVR article: https://doi.org/10.2460/ajvr.25.01.0023

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Veterinary teams are complex systems where communication, shared goals, and mutual respect directly impact workplace satisfaction and staff retention. In this enlightening conversation, researchers Natasha Janke and Jason Coe reveal groundbreaking findings on the power of relational coordination in veterinary practice.

Originally developed in the airline industry to understand Southwest Airlines' exceptional performance, relational coordination has transformed healthcare delivery across multiple fields. Now, for the first time, this powerful framework has been applied to veterinary medicine with remarkable results. Natasha explains that relational coordination thrives in environments characterized by time pressure, uncertainty, and interdependence between roles—a perfect description of the veterinary workplace.

Their research demonstrates significant positive associations between relational coordination and healthier psychological workplace climate, increased job satisfaction, and perhaps most critically for practices struggling with staffing challenges, reduced intention to leave. By focusing on seven core components—frequent, timely, accurate, and problem-solving communication, alongside shared goals, shared knowledge, and mutual respect—veterinary teams can transform their workplace culture.

Dr. Coe's twenty-year journey pursuing this research reveals how veterinary practices can use relational coordination as a diagnostic tool to identify specific areas for improvement rather than implementing broad, sweeping changes. The visual mapping of role interdependencies provides practice leaders with clear insights into team dynamics that might otherwise remain invisible. Both researchers emphasize the importance of including clients in the relational coordination framework, recognizing pet owners as essential members of the veterinary healthcare team.

Listen now to discover how strengthening your team's relational coordination could revolutionize your practice culture, improve staff retention, and ultimately enhance patient care. The evidence is clear—how we work together truly matters for everyone involved in veterinary medicine.

JAVMA article: https://doi.org/10.2460/javma.24.09.0570

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