In the final episode of season 13, after a brief discussion about dog poop DNA, Kyle and Sean reflect on how their priorities, perspectives, and self-image have evolved over time. From awkward teen years and early adult panic to working through tough moments, they explore the power of hindsight and personal growth. The conversation dives into public misperceptions of disability, body image struggles, and the ways they’ve learned to let go of what doesn’t matter. They wrap up with gratitude for a supportive coach and a powerful book recommendation that’s reshaping how Sean thinks about leadership and service.

Links and Resources

• Unreasonable Hospitality

In Episode 276, Kyle kicks things off with a brunch story involving an oversized, impossible-to-handle coffee mug and a series of well-intentioned but clumsy attempts to make it right.

The episode then shifts gears with a fun and thought-provoking compilation of answers from past guests to the question: If you ruled the world, what would you change? Responses range from practical ideas like increasing accessibility and reducing barriers, to grand visions of kindness, open science, and even perfect weather in Pennsylvania. Each guest's answer serves as a reminder of how personal experiences shape our view of what the world could be.

The episode wraps up with heartfelt thank-you notes: Kyle expresses his gratitude to all his generous donors by adding each of their names to his fundraising “spirit chain,” while Sean thanks Santino, a colleague who went out of his way to share how much he enjoyed Sean's recent corporate presentation. These moments of appreciation highlight the power of connection and acknowledgment in both personal and community-driven efforts.

This episode is a reminder that even small gestures can have a world-changing impact.

Links and Resources

• Katie, Team Telomere
• Heidi, Association for Creatine Deficiencies (ACD)
• Jay, Write on, Fight on
• Rivki, CTNNB1 Connect & Cure
• Kendall, Icon
• Erin, Rea of Hope

In this episode, Sean and Kyle kick things off with a nostalgic dive into Kyle’s latest midlife hobby—collecting Sacramento Kings basketball cards from the early 2000s. What began as a simple eBay gift for his nephew spiraled into a full-on tribute to his college years, complete with prized cards now stashed in a personal safe. The dudes banter about their shared sports memories, the glory days of Bibby and Weber, and how even Shaq’s son is now playing ball in Sacramento. It’s a fun and lighthearted reminder that small joys—like cheap sports memorabilia—can spark big waves of meaning.

But the real heart of the episode comes from a face-to-face conversation with longtime friend Katie Stevens, executive director of Team Telomere. Katie opens up about her personal journey as a rare disease mom and how her experience shaped her leadership in the nonprofit space. She shares how Team Telomere has grown from a volunteer-run effort into a structured, strategic organization—with an eye on both care and cure. From care packages and community trust to groundbreaking research and a clinical trial aimed at treating telomere biology disorders, Katie gracefully bridges the science and the soul of rare disease advocacy.

With honesty, wit, and wisdom, Katie reminds us that hope isn’t just a word—it’s a community, a strategy, and a force for action. Whether you’re in the trenches or working toward a cure, this episode delivers powerful insight into what it takes to lead with heart and keep moving forward.

Links and Resources

• Team Telomere