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Dominik Lysek, CEO of PharmaTrail, explains how blockchain technology can solve trust issues in clinical trials by providing an incorruptible audit trail that verifies data integrity. This solution could significantly accelerate the time required for regulatory approvals, partnerships, and acquisitions, ultimately getting treatments to patients faster.

• Blockchain provides a complete, unchangeable audit trail where data can only be added, never deleted
• Most clinical data (99.9%) has integrity, but proving this to outsiders is time-consuming and costly
• PharmaTrail uses private blockchain technology alongside traditional databases for optimal security and functionality
• Blockchain verification can maintain momentum through due diligence processes, preventing deals from stalling
• The technology creates trust by enabling independent verification of data integrity
• Current systems face challenges with data credibility that delay patient access to treatments
• Private blockchains protect patient data while still providing the benefits of immutable record-keeping

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Dr. Shervin Molayem shares his journey of innovation in dentistry, starting with his discovery of a connection between periodontal disease and COVID-19 severity that became the world's most-read dental article of 2020. He discusses groundbreaking technologies including AI-powered diagnostic tools and a revolutionary non-surgical treatment that regenerates bone tissue around teeth.

• Discovered connection between gum disease and COVID-19 severity through interleukin-6 levels
• Developing Trust AI, a dental co-pilot that gives practitioners instant access to research, bridging the 17-year gap between research and practice
• AI dental diagnostics can detect 37% more pathology than human eyes by distinguishing 250 shades of gray versus only 30
• Created non-surgical periodontal regeneration technology using piezoelectric nanoparticles that kill bacteria and stimulate bone growth
• Oral infections affect overall health with links to heart disease, stroke, and Alzheimer's disease
• Clinical research needs greater transparency to eliminate bias, potentially using blockchain technology to make science "fraud-proof"
• The volume of research is doubling every three years, making AI essential for clinicians to keep pace

You can find Dr. Shervin Molayem on LinkedIn or Instagram under "DentalSurgeon," or try his free dental chatbot at shervin@trustdentistryai.com.

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Chris Wood discusses how early diagnostics of lung cancer through artificial intelligence and medical imaging can lead to better survival rates through early intervention.

• Lung cancer takes more lives than breast, prostate and colon cancer combined, with approximately 70% of cases caught at late stages
• The National Lung Screening Trial showed that screening high-risk populations reduced mortality by 20%
• I-ELCAP research demonstrated an 80% twenty-year survival rate for early-stage cancers detected with CT scans and treated surgically
• Preventive healthcare is shifting from general advice to personalized screening protocols based on individual risk factors
• AI applications in medical imaging now assist with detection, characterization, and triage of disease
• Lung biopsies have a 22% complication rate, making non-invasive diagnostic methods particularly valuable
• AI-powered imaging can provide additional information to help clinicians decide whether to perform biopsies
• In clinical trials, AI imaging analysis could improve patient selection and help trials reach endpoints more efficiently
• Medical imaging gives patients visual information about their bodies that can motivate healthier lifestyle changes
• The future of healthcare will likely focus on improving quality of life rather than simply extending lifespan

If you have a suggestion for a guest for our show, reach out to Sam Parnell or Ivanna Rosendal on LinkedIn. You can find more episodes on Apple Podcasts, Spotify, Google Podcasts or in any other player.

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