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Toxic Optic Neuropathy: Free MSRA Podcast

Toxic Optic Neuropathy: Free MSRA Podcast

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 👁️ Toxic Optic Neuropathy – High-Yield Deep DiveDefinitionToxic Optic Neuropathy:Damage to the optic nerve directly from exposure to drugs, chemicals, or toxins, causing vision loss. Not due to pressure, trauma, or inflammation—it’s the substance itself doing the harm. Key Causes – Mnemonic:AABCPHETAlcohols (methanol, ethylene glycol, chronic ethanol abuse)Antibiotics (e.g. chloramphenicol, linezolid, sulfonamides)B Antimalarials (chloroquine, hydroxychloroquine)C Anti-TB drugs (ethambutol—biggest classic; also isoniazid)P PDE inhibitors (e.g. sildenafil)H Heavy metals (lead, mercury)E Antiarrhythmics (amiodarone)T Tobacco/alcohol (especially with poor nutrition)O Others: carbon monoxide, chemotherapy (vincristine), etc. Epidemiology / Risk FactorsMain risk: Exposure to the substances above (chronic use or overdose)At-risk:Long-term use of relevant meds (anti-TB, amiodarone, etc.)Occupational/industrial exposureAlcohol abuse (esp. with poor nutrition/B12 deficiency)Poor diet or malabsorption (B vitamins especially) PathophysiologyDirect toxin damage: Kills/damages optic nerve fibresMitochondrial dysfunction: Disrupts energy supply—especially in papillomacular bundle (central vision)Oxidative stress: Free radicalsMetabolic impairment: Some affect cell metabolism or blood supply Differential DiagnosisGlaucomaOptic neuritis (MS, infection)Ischaemic optic neuropathy (GCA, vascular)Hereditary optic neuropathies (e.g. Leber’s)Compressive lesions (tumour, aneurysm)Nutritional optic neuropathyTrauma, retinal dystrophies Symptoms & SignsBilateral, symmetric, painless, progressive vision lossCentral/cecocentral scotoma (central blind spot) on field testingDyschromatopsia: Poor colour vision, especially red/greenBlurring at fixation (difficulty reading, recognising faces)Visual acuity reducedOptic disc: May be normal early, then pale (optic atrophy)NO RAPD (as both eyes affected equally)History is key: Ask specifically about drug, alcohol, industrial exposure, and nutrition. InvestigationsOphthalmic exam: Visual acuity, colour vision (Ishihara), visual fieldsOCT: Nerve fibre layer thinning (esp. papillomacular bundle)Fundoscopy: May show optic disc pallor (late)Blood tests:B12/folate (rule out nutritional)Toxicology screen (if relevant)MRI/CT of brain/orbits: Rule out compressive or demyelinating lesionsVEP (Visual Evoked Potentials): Delayed responseSlit lamp: For corneal deposits (amiodarone) ManagementIMMEDIATE withdrawal/cessation of causative agentCorrect nutritional deficiencies: B12, folate, general nutritionAntidotes/support:Methanol: Fomepizole, ethanol, correct acidosisEthambutol: Pyridoxine (B6)Heavy metals: ChelationAntioxidants: Sometimes used, but evidence limitedSupportive care: Vision rehab, occupational therapyMonitor: Regular follow-up for acuity, colour, fields, optic nerve appearance PrognosisEarly detection and prompt cessation = best chance of improvementLate diagnosis or severe atrophy: Often permanent lossMost important: Prevent progression, may get partial recovery if caught early ComplicationsPermanent central vision loss (functional impact)Optic atrophySevere, irreversible impairment if not managed quickly Key Takeaway MnemonicAABCPHET for causesBilateral, central, painless, progressive vision lossSTOP the exposure first, then support and supplement MSRA Revision ResourcesToxic Optic Neuropathy Revision NotesToxic Optic Neuropathy FlashcardsAccordion Q&A NotesRapid Fire QuizMain sites:PassTheMSRA.comFreeMSRA.com #MSRA #Ophthalmology#ToxicOpticNeuropathy #PasstheMSRA #FreeMSRA #Revision

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