This episode explores how women’s hormones, aging, regenerative therapies, and technology are shaping the next era of longevity medicine. Dr. Amy Killen shares her evolution from ER doctor to multi-company entrepreneur, her work in stem cells and full-body regenerative procedures, and the role of diagnostics, AI, and hormone optimization in midlife women’s health. You’ll get an inside look at the queen phase of perimenopause, the future of longevity clinics, and how women can stay proactive as they age.

KEY TOPICS

• Estrogen, perimenopause and the queen phase of women’s midlife
• Dr. Killen’s shift from ER medicine to entrepreneurship in longevity
• Stem cells, exosomes and whole-body regenerative therapies
• Reputable Health, Hop Box and Humanát Health’s tech-enabled clinical model
• AI-driven care plans, advanced diagnostics and the future of preventive longevity care
• TIMESTAMPS

[00:00] Estrogen as a forgotten longevity drug and the mental health impact of perimenopause

[00:56] Show intro and framing women’s health, resilience and personal transformation

[01:27] ER burnout, single motherhood and the moment everything shifted

[03:23] Leaving the ER and confronting criticism around hormones and regenerative medicine

[04:08] Partnering with Docere Clinics and developing the Full Body Stem Cell Makeover

[06:33] Stacking stem cells, exosomes, peptides, light therapy and sound therapy

[08:10] Transformations in pain, sexual health and functional recovery using stem cells

[10:09] Musculoskeletal outcomes and delaying joint replacement surgeries

[10:57] Skin quality improvements, subtle rejuvenation and hair restoration in women

[13:33] Stem cells vs PRP and when each modality is most effective

[13:51] Founding Reputable Health to modernize clinical trials using wearables

[15:11] How biohackers join studies and test real supplements and devices

[16:28] Using AI to extract insights from sleep, HRV and wearable data

[16:57] Creating Hop Box as a simple, evidence-based female longevity stack

[18:17] Supplements tailored to female physiology, insulin resistance and skin health

[19:29] Why Hop Box is not a multivitamin and how ingredients like spermidine fit in

[21:06] Defining the queen phase and why women lose hormonal protection

[23:11] Men’s gradual testosterone decline vs women’s hormonal cliff in midlife

[24:52] Stress load in midlife and why so many women struggle in their 40s and 50s

[25:43] Hormone therapy as a foundational pillar for women’s longevity

[26:18] Building Humanát Health as a next-gen longevity clinic franchise

[28:21] Core pillars of longevity care: lifestyle, diagnostics and prevention

[30:39] Comparing Humanát to other longevity and biohacking clinics

[32:36] Evidence-based hormone protocols and training providers at scale

[35:31] How Humanát uses advanced diagnostics and AI-generated care plans

[39:45] Why the franchise model expands access to longevity medicine

[42:54] Membership tiers, affordability and the future of nationwide rollout

[43:41] Inside the Humanát gym: VO2 max, strength, balance and kinetic testing

[44:34] Advice to clinicians entering longevity entrepreneurship

[45:42] The next decade of regenerative medicine and the role of women

[46:41] Balancing motherhood, procedures, multiple companies and travel

[47:45] Where to find her clinics, supplements and platforms

[49:14] Closing reflections on the women’s longevity revolution

Guest: Dr. Amy Killen

Website: https://dramykillen.com/

Instagram: https://www.instagram.com/dr.amybkillen/

LET’S...

Discover how to build lean muscle, balance hormones, and reignite metabolism after 50. In this episode, you’ll learn the science behind muscle as a metabolic organ, how to train smarter (not harder) through menopause, and why recovery and hormone balance are key for strength and longevity. Perfect for women who want to stay strong, lean, and vibrant at any age.

• Muscle as metabolic medicine for women in midlife
• Smart strength training splits and recovery for hormone health
• Balancing HIIT, Zone 2, and daily movement for longevity
• Hormone replacement therapy and testosterone in women
• Protein, creatine, and supplement strategies for women over 50

TIMESTAMPS

[00:00] Why muscle is key to metabolic health and glucose control in midlife

[00:44] Starting bodybuilding at 50 and transforming your body at any age

[01:33] Perimenopause, insulin resistance, and how strength training helps

[03:19] Common training mistakes: too much cardio and skipping a coach

[05:44] How to find the right trainer for women 40–60+

[09:46] Bodybuilding lessons: muscle splits, compound lifts, and progression

[12:37] The best full-body plan for busy women (2–3 days a week)

[14:21] How to train with balance and recovery between workouts

[15:14] Heavy lifting, volume, and tempo — finding your intensity sweet spot

[17:55] Conditioning vs cardio: HIIT, Zone 2, and power training explained

[19:07] The ideal weekly mix for fat loss, recovery, and stress control

[22:30] Daily walking, HRV tracking, and training around your stress load

[27:26] Injury prevention: knees, shoulders, hips, and posture correction

[33:17] Midlife recovery tools: mobility, foam rolling, flexibility, and rest

[34:12] Men vs women in training — why women won’t “bulk up”

[35:04] Estrogen decline, sarcopenia, and how to preserve muscle in menopause

[36:23] HRT and testosterone therapy — benefits, myths, and what to watch for

[41:13] Protein goals and timing for women 40+

[42:54] Carbs, fats, and how to eat for energy and body composition

[44:22] Creatine, protein shakes, and supplement stack for strength

[46:47] Carol’s book, podcast, and where to connect with her online

Guest: Carol Covino

Website: https://carolcovino.com/

Instagram: https://www.instagram.com/carolcovinofitness/

LET’S CONNECT

Host: Orshi McNaughton

Website: https://www.optimizedwomen.com/

YouTube: https://www.youtube.com/@optimizedwomen

Instagram: https://www.instagram.com/orshimcnaughton

Discover how precision diagnostics, regenerative therapies, and AI are redefining the future of personalized healthcare. In this episode, you’ll learn how data-driven medicine, early disease detection, and foundational lifestyle strategies are transforming longevity and empowering women to take control of their healthspan.

💡 KEY TOPICS 💡

• AI and data-driven longevity medicine
• Democratizing access to precision health care
• Foundations of health optimization and lifestyle medicine
• Regenerative therapies and therapeutic plasma exchange
• Women’s hormones, midlife vitality, and personalized care

⏰ TIMESTAMPS ⏰

[00:00] Adding 20 good years of life and redefining longevity

[02:15] The story behind Restore Hyper Wellness and the birth of Humanot Health

[07:31] Building the wellness franchise model and scaling innovation

[12:03] From athlete recovery to chronic inflammation relief

[19:40] Defining health optimization and the role of foundational habits

[23:53] How Humanot bridges fragmented longevity solutions

[28:08] Making advanced therapies more affordable and accessible

[34:24] Standardizing longevity medicine and women’s hormone care

[46:32] How AI is transforming diagnostics and personalized medicine

[54:07] Cutting-edge therapies like therapeutic plasma exchange

[59:54] Preventative and minimally invasive healthcare approaches

[01:00:30] What health optimization means for women in midlife

[01:06:45] Final insights and how to connect with Humanot Health

🌿 GUEST 🌿

Jim Donnelly | CEO & Founder, Humanot Health

Website: https://www.humanauthealth.com

Instagram: https://www.instagram.com/humanauthealth/

LinkedIn: https://www.linkedin.com/in/jimdonnellyhumanaut

💫 LET'S CONNECT 💫

Host: Orshi McNaughton

Website: https://www.optimizedwomen.com

Podcast: https://optimized-women.captivate.fm/listen

YouTube Channel: https://www.youtube.com/@optimizedwomen

Instagram: https://www.instagram.com/orshimcnaughton/

LinkedIn: https://www.linkedin.com/in/orshimcnaughton/

Hair thinning, gray hair, and hair loss don’t have to be inevitable! In this episode, we explore the science of hair health and dive into the root causes of these issues—hormonal imbalances, nutritional deficiencies, and stress. Learn how to restore your hair naturally using a proven system that promotes growth, prevents gray hair, and reverses thinning. Plus, we uncover the effectiveness of popular treatments like PRP, red light therapy, and micro-needling, and share what truly works to help you achieve vibrant, healthy hair.

🔹 What You'll Learn in This Episode:

The root causes of hair thinning and gray hair in women

How hormonal imbalances and stress accelerate hair loss—and what to do about it

The best nutrients, vitamins, and minerals for hair regrowth

A step-by-step system for reversing gray hair naturally

What works (and doesn’t) in hair restoration treatments like PRP and red light therapy

🔑 KEY TOPICS 🔑

Hormones & Hair Loss: How cortisol, estrogen, and thyroid affect your hair

Gray Hair Reversal: Natural ways to reduce hydrogen peroxide buildup

Nutrition for Hair Health: Key vitamins, minerals, and protein sources

Effective Hair Growth Treatments: PRP, microneedling, and red light therapy

The Ultimate Hair Restoration System: Proven steps to regrow and strengthen your hair

🕐 TIMESTAMPS 🕐

[00:00] Introduction & Common Hair Loss Treatments

[03:30] Hormonal Imbalances & Hair Loss Causes

[10:30] Early Signs of Hair Thinning & Genetic Factors

[17:00] Nutritional Deficiencies & Hair Growth Support

[23:30] Stress, Cortisol, and Their Impact on Hair Health

[31:30] Effective Hair Loss Treatments: PRP, Red Light & More

[42:00] The Science Behind Gray Hair & Reversing It

[50:00] How Hair Dyes & Chemicals Affect Hair Health

[57:00] Building a Complete Hair Restoration Routine

[62:00] Final Longevity & Anti-Aging Tips for Hair & Health

🎙️ GUEST: Faraz Khan 🎙️

Website: https://FullyVital.com

Instagram: https://instagram.com/fullyvitalhair

🌐 LET'S CONNECT 🌐

Host: Orshi McNaughton

Website: https://www.optimizedwomen.com/

Podcast Links: https://optimized-women.captivate.fm/listen

YouTube Channel: https://www.youtube.com/@optimizedwomen

Instagram: https://www.instagram.com/orshimcnaughton/

Testosterone levels have dropped by nearly 50% over the past 40 years, creating ripple effects in metabolism, mood, fertility, and longevity. In this episode, you’ll learn why hormones are declining across both men and women, the hidden role of endocrine disruptors, and how lifestyle, TRT, and new oral formulations are changing the conversation about hormone health. Discover the metabolic, cardiovascular, and brain benefits of testosterone and what myths need to be debunked once and for all.

TIMESTAMPS

[00:00] Testosterone decline over the last 40 years and why it matters

[03:27] Causes of low testosterone: obesity, endocrine disruptors, poor sleep

[06:09] Symptoms and metabolic consequences of testosterone deficiency

[09:45] Can lifestyle changes restore testosterone without TRT?

[15:09] How low testosterone shows up in women and its health impacts

[17:01] History of testosterone therapy, stigma, and FDA regulation

[22:16] Current TRT options: injectables, pellets, gels, and compounded creams

[33:06] Innovation in oral testosterone and SHBG reduction

[42:00] Fertility, LH/FSH suppression, and pilot study data

[55:33] Testosterone’s connection to longevity, chronic disease, and healthspan

[58:23] Myths about cardiovascular risk, prostate cancer, and testosterone use

[01:00:51] Hormones as a foundation of health and how to get tested

Guest: Shalin Shah

Website: https://kaisertrex.com

Instagram: https://www.instagram.com/themetabolicceo

🌐 LET'S CONNECT 🌐

Host: Orshi McNaughton

Website: https://www.optimizedwomen.com/

Podcast Links: https://optimized-women.captivate.fm/listen

YouTube Channel: https://www.youtube.com/@optimizedwomen

Instagram: https://www.instagram.com/orshimcnaughton/

Enjoying the podcast? ⭐️⭐️⭐️⭐️⭐️

Don’t forget to subscribe and leave a review to help spread the word!

Women’s health research has historically overlooked critical differences in female biology. In this episode, Katie Moore and Dr. Mackenzie De Jesus join me to uncover the persistent gender gap in health studies. We discuss the implications of male-centric research, the rise of wearable health tech, and how women can take charge of their health with personalized solutions. Discover how new technologies and innovative studies are shaping the future of women’s health research.

🕐 TIMESTAMPS 🕐

[00:00] Introduction to Women’s Health Research

[01:13] Meet Katie Moore and Dr. Mackenzie De Jesus

[02:57] How autoimmune issues uniquely affect women

[05:56] Male-centric health research: The historical context

[11:21] Wearable devices and women’s health

[16:26] Using personalized health data for better outcomes

[25:10] The impact of gender-specific research on health care

[33:38] Participating in health studies with Reputable Health

🎙️ GUESTS 🎙️

Katie Moore and Dr. Mackenzie De Jesus

Join Women's Health Study: https://www.reputable.health/orshi

Instagram: https://www.instagram.com/reputablehealth

LinkedIn: https://www.linkedin.com/company/reputable-health

🌐 LET'S CONNECT 🌐

Host: Orshi McNaughton

Website: https://www.optimizedwomen.com/

Podcast Links: https://optimized-women.captivate.fm/listen

YouTube Channel: https://www.youtube.com/@optimizedwomen

Instagram: https://www.instagram.com/optimizedwomen

https://www.linkedin.com/in/orshimcnaughton/

Enjoying the podcast?

Don’t forget to subscribe and leave a review to help spread the word!

Your vision is more than just seeing clearly—it's a direct reflection of your brain function and overall health. In this episode, we explore the groundbreaking field of neuro-optometry and how vision training can improve focus, mental clarity, energy levels, and even stress resilience. Learn how screen time is impacting your eyesight, why more kids are becoming nearsighted, and what you can do to optimize your vision at any age. Discover natural solutions beyond glasses and contacts to train your eyes and brain for peak performance.

What You'll Learn in This Episode:

🔹 How vision training enhances mental clarity, focus & energy

🔹 The truth about screens & their impact on eyesight

🔹 Why nearsightedness is skyrocketing & how to prevent it

🔹 How hormones, stress & aging affect vision health

🔹 The best strategies to strengthen your eyes & brain

🕐 TIMESTAMPS 🕐

[02:10] What is neuro-optometry & how does it go beyond glasses?

[10:45] The impact of screen time on vision, sleep & mental clarity

[18:30] The nearsightedness epidemic & why kids are affected more

[27:15] How hormones, aging & stress affect women’s eye health

[35:40] Vision training for cognitive function & productivity

[44:00] Concussion recovery, motion sickness & vision therapy

[50:20] How to reduce eye strain & improve digital endurance

[58:00] Nutrition & lifestyle strategies for long-term eye health

🎙️ GUEST: DR. BRYCE APPELBAUM 🎙️

🔗 Website: https://www.myvisionfirst.com/

📸 Instagram: @drbryceappelbaum

📺 ScreenFit Training – Get $200 OFF! Use promo code OPTIMIZED at checkout: https://www.screenfit.com/

🌐 LET'S CONNECT 🌐

Host: Orshi McNaughton

Website: https://www.optimizedwomen.com/

Podcast Links: https://optimized-women.captivate.fm/listen

YouTube Channel: https://www.youtube.com/@optimizedwomen

Instagram: https://www.instagram.com/orshimcnaughton/

⭐️⭐️⭐️⭐️⭐️ Enjoying the podcast?

Don’t forget to subscribe & leave a review to help spread the word!

If you're struggling with fatigue, weight gain, brain fog, or unexplained symptoms despite “normal” labs, this episode will help you uncover what’s really going on. We explore how thyroid dysfunction—especially Hashimoto’s—is often missed, misdiagnosed, or mistreated. Learn the real root causes behind low thyroid function, the truth about lab testing, and what to do when meds aren't working. You’ll walk away with real-world strategies to begin healing your thyroid naturally and reclaim your energy.

TIMESTAMPS

[00:00] Why adrenal exhaustion causes thyroid to slow down

[01:42] Ryan’s decade-long struggle to get diagnosed

[05:06] His TSH was over 150—what that really means

[06:56] Why Hashimoto’s goes undiagnosed in women

[09:27] Why TSH is not a thyroid marker

[13:02] Why doctors dismiss thyroid antibodies

[17:53] Going gluten-free to reverse autoimmune markers

[23:32] Study: gluten increases leaky gut in everyone

[25:51] What is leaky gut and why it matters for Hashimoto’s

[28:53] Molecular mimicry and immune system crossfire

[30:30] Food sensitivity testing and the best elimination diets

[32:17] Cortisol, inflammation, and thyroid damage

[34:53] The role of glutathione in thyroid hormone production

[36:38] Why stress shuts down your thyroid and metabolism

[37:50] Hashimoto’s vs. hypothyroid symptoms

[38:55] Chronic inflammation and autoimmunity

[42:31] The 6 markers you need on every thyroid panel

[47:11] Why Synthroid doesn’t always work

[49:20] Ryan’s antibodies dropped from 1700+ to normal

[54:33] Full testing strategy: gut, toxins, mitochondria

[57:29] Healing strategies to reverse Hashimoto’s naturally

[59:10] Free guide: 10 steps to heal from Hashimoto’s

[1:00:19] What every woman should know about healing

GUEST: Ryan Monahan

Website: https://themindfulnutrivore.com/

Instagram: https://www.instagram.com/themindfulnutrivore/

🌐 LET'S CONNECT 🌐

Host: Orshi McNaughton

Website: https://www.optimizedwomen.com/

Podcast Links: https://optimized-women.captivate.fm/listen

YouTube Channel: https://www.youtube.com/@optimizedwomen

Instagram: https://www.instagram.com/orshimcnaughton/

Enjoying the podcast? ⭐️⭐️⭐️⭐️⭐️

Don’t forget to subscribe and leave a review to help spread the word!