This episode explores how women’s hormones, aging, regenerative therapies, and technology are shaping the next era of longevity medicine. Dr. Amy Killen shares her evolution from ER doctor to multi-company entrepreneur, her work in stem cells and full-body regenerative procedures, and the role of diagnostics, AI, and hormone optimization in midlife women’s health. You’ll get an inside look at the queen phase of perimenopause, the future of longevity clinics, and how women can stay proactive as they age.

KEY TOPICS

• Estrogen, perimenopause and the queen phase of women’s midlife
• Dr. Killen’s shift from ER medicine to entrepreneurship in longevity
• Stem cells, exosomes and whole-body regenerative therapies
• Reputable Health, Hop Box and Humanát Health’s tech-enabled clinical model
• AI-driven care plans, advanced diagnostics and the future of preventive longevity care
• TIMESTAMPS

[00:00] Estrogen as a forgotten longevity drug and the mental health impact of perimenopause

[00:56] Show intro and framing women’s health, resilience and personal transformation

[01:27] ER burnout, single motherhood and the moment everything shifted

[03:23] Leaving the ER and confronting criticism around hormones and regenerative medicine

[04:08] Partnering with Docere Clinics and developing the Full Body Stem Cell Makeover

[06:33] Stacking stem cells, exosomes, peptides, light therapy and sound therapy

[08:10] Transformations in pain, sexual health and functional recovery using stem cells

[10:09] Musculoskeletal outcomes and delaying joint replacement surgeries

[10:57] Skin quality improvements, subtle rejuvenation and hair restoration in women

[13:33] Stem cells vs PRP and when each modality is most effective

[13:51] Founding Reputable Health to modernize clinical trials using wearables

[15:11] How biohackers join studies and test real supplements and devices

[16:28] Using AI to extract insights from sleep, HRV and wearable data

[16:57] Creating Hop Box as a simple, evidence-based female longevity stack

[18:17] Supplements tailored to female physiology, insulin resistance and skin health

[19:29] Why Hop Box is not a multivitamin and how ingredients like spermidine fit in

[21:06] Defining the queen phase and why women lose hormonal protection

[23:11] Men’s gradual testosterone decline vs women’s hormonal cliff in midlife

[24:52] Stress load in midlife and why so many women struggle in their 40s and 50s

[25:43] Hormone therapy as a foundational pillar for women’s longevity

[26:18] Building Humanát Health as a next-gen longevity clinic franchise

[28:21] Core pillars of longevity care: lifestyle, diagnostics and prevention

[30:39] Comparing Humanát to other longevity and biohacking clinics

[32:36] Evidence-based hormone protocols and training providers at scale

[35:31] How Humanát uses advanced diagnostics and AI-generated care plans

[39:45] Why the franchise model expands access to longevity medicine

[42:54] Membership tiers, affordability and the future of nationwide rollout

[43:41] Inside the Humanát gym: VO2 max, strength, balance and kinetic testing

[44:34] Advice to clinicians entering longevity entrepreneurship

[45:42] The next decade of regenerative medicine and the role of women

[46:41] Balancing motherhood, procedures, multiple companies and travel

[47:45] Where to find her clinics, supplements and platforms

[49:14] Closing reflections on the women’s longevity revolution

Guest: Dr. Amy Killen

Website: https://dramykillen.com/

Instagram: https://www.instagram.com/dr.amybkillen/

LET’S...

Discover how to build lean muscle, balance hormones, and reignite metabolism after 50. In this episode, you’ll learn the science behind muscle as a metabolic organ, how to train smarter (not harder) through menopause, and why recovery and hormone balance are key for strength and longevity. Perfect for women who want to stay strong, lean, and vibrant at any age.

• Muscle as metabolic medicine for women in midlife
• Smart strength training splits and recovery for hormone health
• Balancing HIIT, Zone 2, and daily movement for longevity
• Hormone replacement therapy and testosterone in women
• Protein, creatine, and supplement strategies for women over 50

TIMESTAMPS

[00:00] Why muscle is key to metabolic health and glucose control in midlife

[00:44] Starting bodybuilding at 50 and transforming your body at any age

[01:33] Perimenopause, insulin resistance, and how strength training helps

[03:19] Common training mistakes: too much cardio and skipping a coach

[05:44] How to find the right trainer for women 40–60+

[09:46] Bodybuilding lessons: muscle splits, compound lifts, and progression

[12:37] The best full-body plan for busy women (2–3 days a week)

[14:21] How to train with balance and recovery between workouts

[15:14] Heavy lifting, volume, and tempo — finding your intensity sweet spot

[17:55] Conditioning vs cardio: HIIT, Zone 2, and power training explained

[19:07] The ideal weekly mix for fat loss, recovery, and stress control

[22:30] Daily walking, HRV tracking, and training around your stress load

[27:26] Injury prevention: knees, shoulders, hips, and posture correction

[33:17] Midlife recovery tools: mobility, foam rolling, flexibility, and rest

[34:12] Men vs women in training — why women won’t “bulk up”

[35:04] Estrogen decline, sarcopenia, and how to preserve muscle in menopause

[36:23] HRT and testosterone therapy — benefits, myths, and what to watch for

[41:13] Protein goals and timing for women 40+

[42:54] Carbs, fats, and how to eat for energy and body composition

[44:22] Creatine, protein shakes, and supplement stack for strength

[46:47] Carol’s book, podcast, and where to connect with her online

Guest: Carol Covino

Website: https://carolcovino.com/

Instagram: https://www.instagram.com/carolcovinofitness/

LET’S CONNECT

Host: Orshi McNaughton

Website: https://www.optimizedwomen.com/

YouTube: https://www.youtube.com/@optimizedwomen

Instagram: https://www.instagram.com/orshimcnaughton

Discover how precision diagnostics, regenerative therapies, and AI are redefining the future of personalized healthcare. In this episode, you’ll learn how data-driven medicine, early disease detection, and foundational lifestyle strategies are transforming longevity and empowering women to take control of their healthspan.

💡 KEY TOPICS 💡

• AI and data-driven longevity medicine
• Democratizing access to precision health care
• Foundations of health optimization and lifestyle medicine
• Regenerative therapies and therapeutic plasma exchange
• Women’s hormones, midlife vitality, and personalized care

⏰ TIMESTAMPS ⏰

[00:00] Adding 20 good years of life and redefining longevity

[02:15] The story behind Restore Hyper Wellness and the birth of Humanot Health

[07:31] Building the wellness franchise model and scaling innovation

[12:03] From athlete recovery to chronic inflammation relief

[19:40] Defining health optimization and the role of foundational habits

[23:53] How Humanot bridges fragmented longevity solutions

[28:08] Making advanced therapies more affordable and accessible

[34:24] Standardizing longevity medicine and women’s hormone care

[46:32] How AI is transforming diagnostics and personalized medicine

[54:07] Cutting-edge therapies like therapeutic plasma exchange

[59:54] Preventative and minimally invasive healthcare approaches

[01:00:30] What health optimization means for women in midlife

[01:06:45] Final insights and how to connect with Humanot Health

🌿 GUEST 🌿

Jim Donnelly | CEO & Founder, Humanot Health

Website: https://www.humanauthealth.com

Instagram: https://www.instagram.com/humanauthealth/

LinkedIn: https://www.linkedin.com/in/jimdonnellyhumanaut

💫 LET'S CONNECT 💫

Host: Orshi McNaughton

Website: https://www.optimizedwomen.com

Podcast: https://optimized-women.captivate.fm/listen

YouTube Channel: https://www.youtube.com/@optimizedwomen

Instagram: https://www.instagram.com/orshimcnaughton/

LinkedIn: https://www.linkedin.com/in/orshimcnaughton/