Today, I sit down with Dr. Nick Fabiano, MD, a resident psychiatrist, to explore the powerful connection between creatine supplementation and depression. We dive deep into current scientific evidence discussing how creatine, typically known for its athletic performance benefits, might significantly improve mental health and depressive symptoms.

Dr. Fabiano provides an overview of how creatine impacts brain chemistry, energy metabolism, and mood regulation. Whether you're a clinician looking for novel therapeutic approaches, someone battling depressive symptoms, or simply interested in cutting-edge mental health research, this episode offers valuable insights. Don't miss this fascinating conversation on creatine's potential role in mental health!

Key Topics:

• What is creatine and how does it affect the brain?
• Clinical evidence linking creatine supplementation to improved depressive symptoms
• Optimal creatine dosing for mental health benefits
• Potential mechanisms underlying creatine's antidepressant effects

Find Nick here: https://x.com/NTFabiano

Sponsors
A huge thank you to my sponsors for supporting this episode. Check them out and enjoy exclusive discounts:

BonCharge- Get 15% off any product when you visit https://boncharge.com/

Fatty15 - Get 15% off your 90-day Starter Kit when you visit fatty15.com/neuro and use the code NEURO at checkout

The Neuro Athletics Newsletter
Instagram: @louisanicola_
Twitter : @louisanicola_
YouTube: @Louisa Nicola

The Neuro Experience Podcast is proud to have hosted: Dr Andrew Huberman, Dr Gabrielle Lyon, Dr Layne Norton, Thomas DeLauer, Shawn Stevenson, Dr. Rocio Salas-Whalen, Saad Alam, Uma Naidoo, Dr. Lanna Cheuck, Angela Lee Pucci, Jillian Turecki, Dr. Jordan Feigenbaum, Dr. Darren Candow, Dr. Sue Varma, Evy Poumpouras, Dr Casey Means, Renee Deehan, Dr Chris Palmer, Dr Charles Brenner, Dr Joe Zundell, Dr Ray Dorsy, Dr Dale Bredeson, Dr. Ben Bikman

What if one simple change could slash your Alzheimer’s risk by 36%?

In Part 4 of A Woman’s Guide to Alzheimer’s Disease, I uncover the hidden brain dangers of sleep loss, especially for women in perimenopause and menopause. You’ll learn why disrupted sleep isn’t just exhausting, it’s accelerating cognitive decline.

I’ll break down the science of the glymphatic system, the critical role of estrogen and progesterone in REM and deep sleep, and the exact strategies I use to optimize sleep quality. From hormone balance and temperature hacks to supplements and tech, this episode is your complete guide to protecting your brain overnight.

Don’t let sleep sabotage your future, because your brain depends on it.

Sponsors
A huge thank you to my sponsors for supporting this episode. Check them out and enjoy exclusive discounts:

David Protein - It's got no junk, no fake health claims, just a smart science-backed snack that supports lean muscle, appetite control, and recovery. Buy 4 cartons and get the 5th one for free. Just go to davidprotein.com/neuro.

Momentous – Science-backed supplements trusted by elite athletes and experts. Whether you’re looking to improve recovery, performance, or overall wellness, Momentous has you covered. Use code NEURO for 20% off your order: https://www.livemomentous.com/neuro

Goodwipes - If you want to upgrade your restroom ritual with good wipes, go to goodwipes.com, use code NEURO if you're shopping for them online.

The Neuro Athletics Newsletter
Instagram: @louisanicola_
Twitter : @louisanicola_
YouTube: @Louisa Nicola

The Neuro Experience Podcast is proud to have hosted: Dr Andrew Huberman, Dr Gabrielle Lyon, Dr Layne Norton, Thomas DeLauer, Shawn Stevenson, Dr. Rocio Salas-Whalen, Saad Alam, Uma Naidoo, Dr. Lanna Cheuck, Angela Lee Pucci, Jillian Turecki, Dr. Jordan Feigenbaum, Dr. Darren Candow, Dr. Sue Varma, Evy Poumpouras, Dr Casey Means, Renee Deehan, Dr Chris Palmer, Dr Charles Brenner, Dr Joe Zundell, Dr Ray Dorsy, Dr Dale Bredeson, Dr. Ben Bikman

I'm excited to share my conversation with Stuart Phillips, where we dive deep into muscle building science - a topic that generates endless debate on social media. As someone who struggles with gaining muscle despite consistent training, I was shocked when Dr. Christopher Gardner told me muscle growth is "10% nutrition and 90% exercise." This contradicted everything I thought I knew, so I had to bring in Stu - widely considered the foremost expert on muscle development - to separate fact from fiction.

The most fascinating insight for me was discovering that effective muscle building can happen across a wide range of repetition schemes - from as low as 3 reps to as high as 25 reps per set. This challenges the rigid "strength/hypertrophy/endurance" continuum that's dominated fitness advice for decades.

Subscribe to The Neuroscience Experience for more conversations at the intersection of brain science and performance. I'm committed to bringing you evidence-based insights that you can apply to your own health journey.

Episode Timestamps:
0:00:00 - Introduction
0:03:52 - How Protein & Exercise Affects Muscle Growth
0:08:16 - Do Men and Women Respond Differently to Exercise?
0:11:05 - Importance of Lifting Weights for Muscle Growth
0:13:09 - Exercise Routines for Aging and Maintaining Health
0:23:47 - Strength Training for Alzheimer’s Prevention
0:31:39 - HRT and Muscle Loss
0:35:30 - Genetic Factors in Muscle Building
0:39:38 - 4 Pillars of Healthy Living
0:43:07 - How GLP-1 Impacts Weight Loss and Muscle
0:48:20 - How Resistance Training Impacts Muscle Hypertrophy
0:58:41 - Gender Differences in Muscle Adaptation
1:02:42 - Conclusion

Sponsors
A huge thank you to my sponsors for supporting this episode. Check them out and enjoy exclusive discounts:

Caraway – Cook clean, live clean. Head to carawayhome.com/neuro and use code NEURO to get 10% off your next purchase.

MUD/WTR - The coffee alternative. If you're ready to ditch the crash and sip smarter, go to mudwtr.com and use code NEURO to get 43% off + free shipping.

Fatty15 - Get 15% off your 90-day Starter Kit when you visit fatty15.com/neuro and use the code NEURO at checkout

The Neuro Athletics Newsletter
Instagram: @louisanicola_
Twitter : @louisanicola_
YouTube: @Louisa Nicola

The Neuro Experience Podcast is proud to have hosted: Dr Andrew Huberman, Dr Gabrielle Lyon, Dr Layne Norton, Thomas DeLauer, Shawn Stevenson, Dr. Rocio Salas-Whalen, Saad Alam, Uma Naidoo, Dr. Lanna Cheuck, Angela Lee Pucci, Jillian Turecki, Dr. Jordan Feigenbaum, Dr. Darren Candow, Dr. Sue Varma, Evy Poumpouras, Dr Casey Means, Renee Deehan, Dr Chris Palmer, Dr Charles Brenner, Dr Joe Zundell, Dr Ray Dorsy, Dr Dale Bredeson, Dr. Ben Bikman

Why are women twice as likely to develop Alzheimer’s disease—especially during and after menopause? The answer goes far beyond age, and what I reveal in this episode might change how you think about your brain forever.

In Part 3 of A Woman’s Guide to Alzheimer’s Disease, I uncover the hidden hormonal and genetic factors that put women at greater risk—and the steps you must take before symptoms ever begin. I’ll walk you through the six most powerful prevention strategies, the critical tests your doctor probably hasn’t mentioned, and the one conversation that could completely reshape your cognitive future.

Sponsors
A huge thank you to my sponsors for supporting this episode. Check them out and enjoy exclusive discounts:

Branch Basics - That’s 15% off your New Branch Basics Premium Starter Kit at BranchBasics.com with promo code NEURO. Make the change today—because you and your family deserve better.

Momentous – Science-backed supplements trusted by elite athletes and experts. Whether you’re looking to improve recovery, performance, or overall wellness, Momentous has you covered. Use code NEURO for 20% off your order: https://www.livemomentous.com/neuro

Troscriptions – Unlock your cognitive potential with precision-dosed nootropics developed by medical experts. Whether you need more focus, clarity, or energy, Troscriptions offers innovative solutions.
- Get 10% off: https://troscriptions.com/NEURO
- https://troscriptions.com/discount/NEUROMAIL?utm_source=affiliate&utm_medium=email&utm_campaign=NeuroMail

The Neuro Athletics Newsletter
Instagram: @louisanicola_
Twitter : @louisanicola_
YouTube: @Louisa Nicola

The Neuro Experience Podcast is proud to have hosted: Dr Andrew Huberman, Dr Gabrielle Lyon, Dr Layne Norton, Thomas DeLauer, Shawn Stevenson, Dr. Rocio Salas-Whalen, Saad Alam, Uma Naidoo, Dr. Lanna Cheuck, Angela Lee Pucci, Jillian Turecki, Dr. Jordan Feigenbaum, Dr. Darren Candow, Dr. Sue Varma, Evy Poumpouras, Dr Casey Means, Renee Deehan, Dr Chris Palmer, Dr Charles Brenner, Dr Joe Zundell, Dr Ray Dorsy, Dr Dale Bredeson, Dr. Ben Bikman

In this conversation with Dr. Christopher Gardner, we debunk a common nutrition myth—that we need massive protein to build muscle. You might know Dr. Gardner from his twin study featured on Netflix, which explores how diets affect our bodies. We discuss protein requirements, diet quality, and sustainable eating. Plus, Dr. Gardner reveals insights from his DIETFITS Study and SWAP-MEAT trial, challenging conventional views on weight loss and plant-based diets.

For science-backed nutrition insights, this conversation cuts through the hype and offers strategies that might change how you think about protein and diet.
If you're interested in evidence-based nutrition that cuts through industry hype, this conversation provides scientific clarity and actionable strategies that might change how you think about protein and diet quality.

Subscribe to The Neuro Experience for more evidence-based health insights.

Sponsors
A huge thank you to my sponsors for supporting this episode. Check them out and enjoy exclusive discounts:

Hone Health – Take control of your hormones with at-home testing designed specifically for men. Get personalized insights and expert guidance to optimize your health and performance. Learn more at: https://honehealth.com/

Momentous – Science-backed supplements trusted by elite athletes and experts. Whether you’re looking to improve recovery, performance, or overall wellness, Momentous has you covered. Use code NEURO for 20% off your order: https://www.livemomentous.com/neuro

Troscriptions – Unlock your cognitive potential with precision-dosed nootropics developed by medical experts. Whether you need more focus, clarity, or energy, Troscriptions offers innovative solutions.
- Get 10% off: https://troscriptions.com/NEURO
- https://troscriptions.com/discount/NEUROMAIL?utm_source=affiliate&utm_medium=email&utm_campaign=NeuroMail

Episode Timestamps:

00:00 Protein Myths & Leucine Threshold
02:58 Daily Protein RDA for Muscle Growth
06:17 Nitrogen Balance & Protein Recommendations
11:42 Nutrition vs. Exercise for Muscle-Building
16:37 Women’s Fitness: Protein & Resistance Training
20:14 DIETFITS Study: Diet Quality vs. Macronutrient Composition
39:17 SWAP-MEAT Trial: Plant-Based vs. Red Meat
50:04 Impact of Nutrition Education on Health
53:18 The Protein Flip & Plant-Based Menus
59:14 Netflix Twin Study: Addressing Misconceptions & Criticisms

The Neuro Athletics Newsletter
Instagram: @louisanicola_
Twitter : @louisanicola_
YouTube: @Louisa Nicola

The Neuro Experience Podcast is proud to have hosted: Dr Andrew Huberman, Dr Gabrielle Lyon, Dr Layne Norton, Thomas DeLauer, Shawn Stevenson, Dr. Rocio Salas-Whalen, Saad Alam, Uma Naidoo, Dr. Lanna Cheuck, Angela Lee Pucci, Jillian Turecki, Dr. Jordan Feigenbaum, Dr. Darren Candow, Dr. Sue Varma, Evy Poumpouras, Dr Casey Means, Renee Deehan, Dr Chris Palmer, Dr Charles Brenner, Dr Joe Zundell, Dr Ray Dorsy, Dr Dale Bredeson, Dr. Ben Bikman

In this conversation with Dr. Heather Sandison, we explore what I consider to be one of medicine's most significant misunderstandings—that Alzheimer's disease, particularly in women, is an unstoppable fate. We examine the evidence behind cognitive decline, hormones, lifestyle interventions, and a framework for preventing and even reversing what was once considered irreversible.

If you're interested in making evidence-based decisions about your brain health, understanding why traditional approaches have failed, or learning about the powerful role of lifestyle interventions in cognitive function, this episode provides both the scientific rationale and actionable strategies you need.

Subscribe to The Neuroscience Experience for more conversations that challenge conventional thinking about brain health. I'm committed to bringing you insights that transform how we approach cognitive aging and performance.

Sponsors
A huge thank you to my sponsors for supporting this episode. Check them out and enjoy exclusive discounts:

Hone Health – Take control of your hormones with at-home testing designed specifically for men. Get personalized insights and expert guidance to optimize your health and performance. Learn more at: https://honehealth.com/

Momentous – Science-backed supplements trusted by elite athletes and experts. Whether you’re looking to improve recovery, performance, or overall wellness, Momentous has you covered. Use code NEURO for 20% off your order: https://www.livemomentous.com/neuro

Troscriptions – Unlock your cognitive potential with precision-dosed nootropics developed by medical experts. Whether you need more focus, clarity, or energy, Troscriptions offers innovative solutions.
- Get 10% off: https://troscriptions.com/NEURO
- https://troscriptions.com/discount/NEUROMAIL?utm_source=affiliate&utm_medium=email&utm_campaign=NeuroMail

Episode Timestamps:

• 00:00 Why Are Women More Vulnerable to Alzheimer’s?
• 06:13 The Role of Hormone Replacement Therapy
• 11:24 Understanding Alzheimer’s Disease and Dementia
• 17:04 Alzheimer's Drugs vs. Lifestyle Interventions That Work
• 29:50 APOE Gene, Genetic Risk, Lipids, and Cholesterol in Alzheimer’s
• 37:47 How the Ketogenic Diet Impacts Brain Health
• 41:11 GLP-1 Agonists and Their Role in Cognitive Health
• 44:30 How Infections Contribute to Cognitive Decline
• 48:00 Plasma Exchange and Alternative Therapies
• 52:09 Foundational Health Practices & Dual Task Exercise
• 54:17 Conclusion and Further Resources

The Neuro Athletics Newsletter
Instagram: @louisanicola_
Twitter : @louisanicola_
YouTube: @Louisa Nicola

The Neuro Experience Podcast is proud to have hosted: Dr Andrew Huberman, Dr Gabrielle Lyon, Dr Layne Norton, Thomas DeLauer, Shawn Stevenson, Dr. Rocio Salas-Whalen, Saad Alam, Uma Naidoo, Dr. Lanna Cheuck, Angela Lee Pucci, Jillian Turecki, Dr. Jordan Feigenbaum, Dr. Darren Candow, Dr. Sue Varma, Evy Poumpouras, Dr Casey Means, Renee Deehan, Dr Chris Palmer, Dr Charles Brenner, Dr Joe Zundell, Dr Ray Dorsy, Dr Dale Bredeson, Dr. Ben Bikman

I'm excited to share my conversation with Dr. Scott Sherr, where we dive deep into methylene blue - a compound you've probably seen all over social media lately (those blue tongues!). As someone whose primary research focuses on Alzheimer's disease, I was fascinated to explore the science behind this molecule that dates back to the 1870s and was actually the first drug registered with the FDA in 1897.

The most fascinating insight for me was learning how methylene blue can serve as an electron acceptor in our mitochondria - essentially functioning as a substitute for oxygen when our cells are under stress. This explains why it shows promise for everything from traumatic brain injury to cognitive enhancement and even as a potential alternative to stimulant medications.

If you're interested in optimizing brain performance, understanding mitochondrial health, or simply curious about this blue compound that's suddenly everywhere, this episode provides both the scientific foundation and practical applications you need.

Subscribe to The Neuroscience Experience for more conversations at the intersection of brain science and performance. I'm committed to bringing you evidence-based insights that you can apply to your own health journey.

Sponsors
A huge thank you to my sponsors for supporting this episode. Check them out and enjoy exclusive discounts:

Hone Health – Take control of your hormones with at-home testing designed specifically for men. Get personalized insights and expert guidance to optimize your health and performance. Learn more at: https://honehealth.com/

Momentous – Science-backed supplements trusted by elite athletes and experts. Whether you’re looking to improve recovery, performance, or overall wellness, Momentous has you covered. Use code NEURO for 20% off your order: https://www.livemomentous.com/neuro

Troscriptions – Unlock your cognitive potential with precision-dosed nootropics developed by medical experts. Whether you need more focus, clarity, or energy, Troscriptions offers innovative solutions.
- Get 10% off: https://troscriptions.com/NEURO
- https://troscriptions.com/discount/NEUROMAIL?utm_source=affiliate&utm_medium=email&utm_campaign=NeuroMail

Timestamps
00:00 Introduction
02:30 Methylene Blue's Role in Neurotransmitter Regulation
07:54 Mitochondrial Health and Methylene Blue
17:02 Methylene Blue and Modern Health Challenges
25:27 Methylene Blue in Hypobaric and Hyperbaric Environments
29:47 Understanding Hyperbaric Oxygen Therapy
32:27 Methylene Blue: A Mitochondrial Rescue
36:52 Bioavailability of Methylene Blue
42:17 Dosing and Applications of Methylene Blue
47:46 Combining Methylene Blue with Other Treatments
54:02 Conclusion and Further Resources

The Neuro Athletics Newsletter
Instagram: @louisanicola_
Twitter : @louisanicola_
YouTube: @Louisa Nicola

The Neuro Experience Podcast is proud to have hosted: Dr Andrew Huberman, Dr Gabrielle Lyon, Dr Layne Norton, Thomas DeLauer, Shawn Stevenson, Dr. Rocio Salas-Whalen, Saad Alam, Uma Naidoo, Dr. Lanna Cheuck, Angela Lee Pucci, Jillian Turecki, Dr. Jordan Feigenbaum, Dr. Darren Candow, Dr. Sue Varma, Evy Poumpouras, Dr Casey Means, Renee Deehan, Dr Chris Palmer, Dr Charles Brenner, Dr Joe Zundell, Dr Ray Dorsy, Dr Dale Bredeson, Dr. Ben Bikman

Alzheimer’s doesn’t just “happen” later in life—it’s a slow, silent process that can begin decades before symptoms appear. In this solo episode, we challenge the myth that Alzheimer’s is purely genetic, and break down what the science really says about your risk.

I explore the role of the APOE4 gene, how it interacts with lifestyle and metabolic health, and why women—especially during and after menopause—may face a unique vulnerability. Most importantly, I introduce three cutting-edge blood tests that can detect the earliest signs of Alzheimer’s, long before memory loss sets in.

We’ll also talk prevention: from blood sugar and insulin resistance to inflammation, hormone balance, and brain energy metabolism—everything you can start doing right now to safeguard your cognitive future.

This is more than a conversation about Alzheimer’s—it’s a roadmap for taking control of your brain health.

Sponsors
A huge thank you to my sponsors for supporting this episode. Check them out and enjoy exclusive discounts:

ZocDoc – Finding a great doctor has never been easier. With ZocDoc, you can browse top-rated physicians, read real patient reviews, and book appointments online - all in one place. Get started here: https://www.zocdoc.com/neuro

Hone Health – Take control of your hormones with at-home testing designed specifically for men. Get personalized insights and expert guidance to optimize your health and performance. Learn more at: https://honehealth.com/

Momentous – Science-backed supplements trusted by elite athletes and experts. Whether you’re looking to improve recovery, performance, or overall wellness, Momentous has you covered. Use code NEURO for 20% off your order: https://www.livemomentous.com/neuro

Troscriptions – Unlock your cognitive potential with precision-dosed nootropics developed by medical experts. Whether you need more focus, clarity, or energy, Troscriptions offers innovative solutions.
- Get 10% off: https://troscriptions.com/NEURO
- https://troscriptions.com/discount/NEUROMAIL?utm_source=affiliate&utm_medium=email&utm_campaign=NeuroMail

Timestamps:
00:00 Top Alzheimer’s Myth: Genetics Don’t Seal Your Fate
01:43 APOE4 Gene Explained: Risk Factors vs. Reality
04:00 Alzheimer’s Risk Isn’t Just in Your DNA
10:50 Top 3 Alzheimer’s Biomarkers You Can Test for Today
14:47 APOE4 Prevention Plan: Lifestyle Changes That Protect Your Brain

The Neuro Athletics Newsletter
Instagram: @louisanicola_
Twitter : @louisanicola_
YouTube: @Louisa Nicola

The Neuro Experience Podcast is proud to have hosted: Dr Andrew Huberman, Dr Gabrielle Lyon, Dr Layne Norton, Thomas DeLauer, Shawn Stevenson, Dr. Rocio Salas-Whalen, Saad Alam, Uma Naidoo, Dr. Lanna Cheuck, Angela Lee Pucci, Jillian Turecki, Dr. Jordan Feigenbaum, Dr. Darren Candow, Dr. Sue Varma, Evy Poumpouras, Dr Casey Means, Renee Deehan, Dr Chris Palmer, Dr Charles Brenner, Dr Joe Zundell, Dr Ray Dorsy, Dr Dale Bredeson, Dr. Ben Bikman