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The Health Edge: translating the science of self-care

The Health Edge: translating the science of self-care

By: Mark Pettus MD and John Bagnulo PhD MPH
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“It’s not what we don’t know that gets us into trouble. It’s what we know that ain’t so”.

Will Rogers


We believe the explosion of life science research from many disciplines had catapulted ahead of our capacity to process, integrate, understand, and apply. We are interested in translating all that is out there as news to use. A fundamentally different understanding of human biology has emerged. The implications from the perspective of self-care are profound. We are rapidly moving away from the debate of nature versus nurture toward an understanding that life emerges from a dynamic landscape of nature via nurture.

We are passionate about the science. We are passionate about the implications. We believe in the capacity and possibility made possible by being alive here and now! We are beautifully designed to be on the African Savannah, living fully integrated with our planet, and in the context of social relationship. Our modern environment is not well designed to promote human health and the capacity to thrive. Many are struggling to maintain balance and traction in lives that often feel overwhelming and frightening.The challenge is to better leverage our superb ancestral adaptation for a different and radically challenging modern environment. Everything that touches us today has the potential be be very familiar or totally foreign. The less aware one is of the day to day distance between what we are biologically , as a species, “familiar with” and what we actually encounter, the fewer the possibilities for more effective alignment.

Leaving one’s health trajectory to chance in our modern environment is a very risky proposition. We are interested in holding the science to the light with an open and humbled mindset. Like you, We are intrepid explorers interested in how we emerge in the midst of our relationship with the environmental inputs of our lives…how we eat, how we move, how we sleep, how we navigate the mind fields of conflict in our lives, how socially connected we are, how we manage the burden of environmental toxins in our lives, how much meaning we cultivate in our work, love, play and how we interpret and respond to stress in our lives. We will drill deep, share all that my experiences has taught and do all that we can to create value for you as you seek to find your health edge. We always welcome your feedback.

Mark and John

© 2025 The Health Edge: translating the science of self-care
Alternative & Complementary Medicine Hygiene & Healthy Living Physical Illness & Disease
Episodes
  • If Light Is A Language, What Is Your Body Hearing?
    Nov 19 2025

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    What if your lighting is sending the wrong message to your biology? We dig into the science of light as information, showing how specific wavelengths trigger opsins in the eyes and skin to set circadian rhythm, shape metabolism, and influence mood, sleep, and aging. From violet and sky-blue that kick-start morning alertness to red and near-infrared that support mitochondrial function, collagen, and nitric oxide, we connect the dots between spectrum quality and everyday health.

    We unpack why standard LEDs, optimized for brightness and efficiency, often omit key wavelengths and oversupply blue at night, creating “junk light” that confuses the body clock. You’ll hear how melanopsin responds to 480 nm for daytime timing, how vitamin A, DHA, and zinc support receptor flexibility, and why quantum effects like exclusion zone water and electron tunneling matter for energy production. We also point to real-world applications: blue light therapy for infant jaundice, UV for hospital sterilization, and the growing case for red and near-infrared in recovery and wound healing.

    Most importantly, we translate the science into steps you can use right now. Get outside for a few minutes of morning light. Bring in a full-spectrum or tunable lamp for daytime work. After sunset, drop brightness below 100 lumens and cut blue to protect sleep. Consider targeted red or near-infrared for soreness and winter resiliency, and track your changes with sleep scores or glucose trends. Food and fitness move the needle, but aligning your light may be the missing lever. If this episode helps you rethink your environment, share it with a friend, hit follow, and leave a review to tell us what light change you’ll make tonight.

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    50 mins
  • Is Coconut Oil A Villain Or Just Misunderstood? Spoiler: It’s Complicated
    Oct 22 2025

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    Curious why coconut oil can raise LDL for some people yet still show up in diets that improve metabolic health, cognition, and body composition? We get clear on what coconut oil actually is—a family of saturated fats with a rare abundance of medium-chain triglycerides—and why MCTs create ketones that the brain and mitochondria can use even without fasting. Instead of stopping at cholesterol, we look at the fuller picture: insulin resistance, inflammation, triglycerides, and real-world outcomes that drive risk more than a single lab value.

    We dig into the differences between MCT oil, extra-virgin coconut oil, and refined coconut oil, and when each makes sense. We compare biomarkers to hard endpoints, explain why some populations with high coconut intake have low cardiovascular disease, and explore how diet context flips the script: in a high-sugar diet, lipids can look worse; in a lower-carb, whole-food pattern, markers of metabolic syndrome often improve even if LDL nudges up. Along the way, we share insights on cooking stability, oxidative stress, and the intriguing idea that latitude and season may influence how fats signal thermogenesis and photoprotection.

    You’ll leave with practical takeaways you can use today: how to choose between MCTs and whole coconut oil, how to integrate them into a low-sugar, nutrient-dense diet, and which labs to track beyond LDL, like ApoB, triglyceride-to-HDL ratio, hs-CRP, and fasting insulin. If you’ve wondered whether coconut oil is a villain or a misunderstood ally, this conversation offers a grounded, outcome-focused way to decide what fits your body and your climate.

    Enjoyed the conversation? Follow the show, share it with a friend, and leave a quick review so more people can find it.

    www.thehealthedgepodcast.com

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    43 mins
  • Your gut can turn ellagic acid into urolithin A—and that shift may protect muscle, brain, and metabolism
    Oct 15 2025

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    If pomegranates, raspberries, and walnuts could whisper a secret to your cells, it might be this: the right microbes can turn plant defense into human resilience. We dive into the journey from ellagic acid to urolithin A, mapping how polyphenols meet the microbiome to support mitochondrial function, muscle strength, and brain health. Along the way, we unpack the science of mitophagy, inflammation control, and metabolic signaling that ties colorful foods to better performance and longevity.

    We share why only an estimated 20–40% of people currently convert ellagic acid to urolithin A, and what that means for your choices. You’ll hear practical ways to build a food-first foundation—pomegranate arils or juice (mind the sugar), raspberries, blackberries, and walnuts—while nurturing a diverse microbiome with fiber-rich meals. We also explore when direct urolithin A supplementation might be considered, what early trials show for strength and function, and how to think about testing—from proprietary blood kits to broader stool profiling—without getting lost in the weeds.

    Throughout, we keep one principle in focus: hormesis. Whole-food antioxidants rarely overwhelm, but concentrated interventions can mute the low-level stress signals that spark repair. By pairing smart training, adequate protein, and polyphenol-rich foods, you create overlapping pathways for mitochondrial renewal and metabolic health—even if you’re not yet a “converter.” Subscribe for more evidence-led, kitchen-to-cell insights, and leave a review to tell us: are you going food-first, testing, supplementing, or blending all three?


    For video, Powerpoint slides and referenced research go to www.thehealthedgepodcast.com

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    40 mins
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