Episodes

  • Antimemetics: Why Some Ideas Resist Spreading | Nadia Asparouhova (Writer and Researcher)

    Antimemetics: Why Some Ideas Resist Spreading | Nadia Asparouhova (Writer and Researcher)
    Jun 10 2025
    Some ideas spread like wildfire. Others vanish before they take root—too strange, too threatening, too forgettable. In this episode of The Generalist, I sit down with Nadia Asparouhova, author of Antimemetics: Why Some Ideas Resist Spreading, to explore the category of “antimemes”: ideas that actively resist being remembered or shared. Drawing from science fiction, epidemiology, and her own unusual cognitive wiring, Nadia maps the shadowy terrain of information that doesn’t want to be shared. We talk about taboos, group chat dynamics, and the hidden incentives shaping what spreads and what doesn’t.In our conversation, we explore:• What antimemes are and why some ideas actively resist being remembered or shared• How taboos, cognitive biases, and uncomfortable truths function as self-censoring ideas• The 2x2 matrix of ideas: memes, antimemes, supermemes, and forgettable non-memes• How group chats are changing idea evolution by acting as high-trust, high-density incubators• How internet slang terms like “vibes” and “cringe” reflect deeper shifts in how we share information• Why great innovation often comes from people willing to look foolish• The critical roles of "truth tellers" and "champions" in preserving important ideas• How memory, aphantasia, and synesthesia shaped Nadia’s sensitivity to forgotten ideas• How local knowledge (wisdom) differs from global knowledge (facts), and why it’s harder to pass down• How Nadia’s experience as a parent shifted her thinking from nurture to nature• How to protect your mental space in an age of information overload—Thank you to the partners who make this possibleWorkOS: The modern identity platform for B2B SaaS.Brex: The banking solution for startups.Generalist+: Essential intelligence for modern investors and technologists.—Timestamps(00:00) Intro(04:45) A brief overview of Nadia’s writing(06:24) Richard Dawkins’s definition of a meme(08:02) Antimemes and a brief overview of the book There Is No Antimemetics Division(11:54) Why daylight savings time is the perfect antimeme(13:13) How neurodivergence shapes Nadia’s creativity(16:20) Synesthesia explained(18:02) Solomon Shereshevsky, a case of extreme synesthesia(18:52) Why forgetting can be a superpower(22:45) Why some ideas spread and others do not(25:11) The 2x2 matrix of ideas(27:20) A warning about supermemes(29:43) Group chats and the evolution of ideas(34:44) Are supermemes organic or engineered?(40:43) The role of truth tellers and champions(45:38) What it means to have “purity of purpose”(46:48) Nadia’s experience with altered states of consciousness, and an example of a champion(51:02) How Nadia’s fear of sharing has lessened, and a case for examining your own fears(52:51) Understanding the internet slang words “vibes” and “cringe”(57:35) Global vs. local knowledge and how it shapes Nadia’s parenting(1:05:01) Where Nadia finds her ideas(1:08:40) How Nadia protects her time to allow for deep work(1:12:38) Final meditations—Follow Nadia AsparouhovaNewsletter: https://nayafia.substack.com/LinkedIn: https://www.linkedin.com/in/nadia-asparouhova/X: https://x.com/nayafia—Resources and episode mentions—Books—• Antimemetics: Why Some Ideas Resist Spreading: https://www.amazon.com/Antimemetics-Some-Ideas-Resist-Spreading-ebook/dp/B0F8J9HHCB• There Is No Antimemetics Division: https://www.amazon.com/There-No-Antimemetics-Division-qntm/dp/B0915M7T61\• A Primer for Forgetting: Getting Past the Past: https://www.amazon.com/Primer-Forgetting-Getting-Past/dp/0374237212• René Girard's Mimetic Theory: https://www.amazon.com/Girards-Mimetic-Studies-Violence-Mimesis/dp/1611860776...Episode resources continued at: https://www.generalist.com/p/antimemetics-nadia-asparouhova—Production and marketing by penname.co. For inquiries about sponsoring the podcast, email jordan@penname.co.
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    1 hr and 19 mins
  • Creating Stars in a Bottle: The Race to Commercialize Fusion Energy | Vinod Khosla & Bob Mumgaard

    Creating Stars in a Bottle: The Race to Commercialize Fusion Energy | Vinod Khosla & Bob Mumgaard
    Jun 3 2025
    While the world fights over chips, one company is building the power supply to run them all. In this episode of The Generalist, I'm joined by Bob Mumgaard, CEO and co-founder of Commonwealth Fusion Systems (CFS), and Vinod Khosla, legendary venture capitalist and founder of Khosla Ventures. With over 800 employees and $2 billion in funding, CFS has accelerated the timeline for commercial fusion from being perpetually "30 years away" to potentially just a few years out. If CFS succeeds, it will unlock limitless clean energy for humanity, powering everything from AI to water desalination.In our conversation, we explore:• How fusion could transform everything from AI to water desalination and agriculture• The fundamental science behind fusion energy and how it differs from traditional nuclear fission• The breakthrough in magnet technology that changed the timeline for fusion• The strategic approach of partnering with existing power plant operators to rapidly scale fusion deployment• Why fusion is essential for powering AI and other energy-intensive innovations• CFS’s method for creating fusion using magnetic fields• The final hurdles to completing SPARC, the company’s demonstration reactor• The six-stage roadmap for fusion development, where CFS currently stands, and when they expect to begin delivering power to the grid• What clean energy could make possible for future technologies and industries• The geopolitical implications of a world with abundant clean energy• Much more—Transcript: https://www.generalist.com/p/creating-stars-in-a-bottle—Thank you to the partners who make this possible⁠Brex⁠: The banking solution for startups.⁠Generalist+⁠: Essential intelligence for modern investors and technologists.—Timestamps(00:00) Intro(04:13) An overview of fusion energy, and why it’s so important(08:23) The connection between AI and fusion energy(10:20) How Bob became interested in fusion(13:06) The importance of entrepreneurs in bringing crazy ideas to life(14:55) The advancement in magnets that caused the leap in fusion technology(17:33) The extreme conditions required for fusion(19:46) What made Vinod interested in funding CFS(21:30) The alternatives that CFS looked at if the magnet hadn’t worked(25:18) Different methods for creating fusion(27:43) Bob’s entrepreneurial lens for fusion at scale(31:52) CFS’s strategy of partnering with existing power infrastructure(35:32) An overview of ARC and SPARC(40:03) Final hurdles to complete SPARC(42:29) The six-stage roadmap for fusion development(46:11) What clean energy unlocks(48:06) Entrepreneurial opportunities for supporting fusion power(50:43) Final meditations—Follow Vinod KhoslaLinkedIn: ⁠https://www.linkedin.com/in/vinod-khosla-65387416/⁠X: ⁠https://x.com/vkhosla⁠—Follow Bob MumgaardLinkedIn: ⁠https://www.linkedin.com/in/mumgaard/⁠X: ⁠https://x.com/BobMumgaard⁠—Resources and episode mentions—Books—• Unweaving The Rainbow: Science, Delusion and the Appetite for Wonder: ⁠https://www.amazon.com/Unweaving-Rainbow-Science-Delusion-Appetite/dp/0618056734⁠• The Intel Trinity: How Robert Noyce, Gordon Moore, and Andy Grove Built the World's Most Important Company: ⁠https://www.amazon.com/Intel-Trinity-Robert-Important-Company/dp/0062226762⁠—People—• Elon Musk on X: ⁠https://x.com/elonmusk⁠—Other resources—• Commonwealth Fusion Systems: ⁠https://cfs.energy/⁠• Sun Microsystems: ⁠https://en.wikipedia.org/wiki/Sun_Microsystems⁠• OpenAI: ⁠https://openai.com/⁠• Moore’s Law: ⁠https://en.wikipedia.org/wiki/Moore%27s_law⁠• The Hunt for Red October: ⁠https://www.imdb.com/title/tt0099810/⁠• Magnetohydrodynamic drive: ⁠https://en.wikipedia.org/wiki/Magnetohydrodynamic_drive⁠• ITER: ⁠https://www.iter.org/⁠...Resources continued at: https://www.generalist.com/p/creating-stars-in-a-bottle—Production and marketing by ⁠penname.co⁠. For inquiries about sponsoring the podcast, email jordan@penname.co.
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    55 mins
  • The Semiconductor Century with Chris Miller (Author of “Chip War”)

    The Semiconductor Century with Chris Miller (Author of “Chip War”)
    May 27 2025
    What really determines success in the age of AI? Is it better models or broader reach? Chris Miller, author of the bestselling book Chip War, explains how semiconductors have become the strategic center of gravity for global power, economics, and innovation. As a professor at the Fletcher School at Tufts University, Chris has spent nearly a decade studying how chips are reshaping geopolitics and why they're essential to understanding everything from military capabilities to artificial intelligence.In our conversation, we explore:• Why diffusion and adoption of technology are more important markers of impact than actual capabilities• What most people got wrong about DeepSeek's breakthrough, but why China's AI talent still matters• Huawei's surprising transformation from telecom giant to potential AI powerhouse• The critical role India and Southeast Asia may play in chip manufacturing• How the Trump administration's policies will impact the technological battle• Why China will likely achieve semiconductor self-sufficiency in mainstream chips within five years• Barriers to rebuilding a domestic chip industry in the US• The massive infrastructure investments being made in AI computing power• The implications of Stargate• And much more!—For a full transcript of the episode, please visit: https://thegeneralist.substack.com/p/the-semiconductor-century-with-chris-miller—Thank you to the partners who make this possibleGeneralist+: Essential intelligence for modern investors and technologists.Explo: Customer-facing analytics for any platform.—Timestamps(00:00) Intro(04:06) A brief overview of Chip War(06:10) Why Chris believes we are on the cusp of a new technological era(08:03) Why the diffusion of technology is the true marker of impact(09:29) Chris’s thoughts on enterprise adoption of AI(11:03) Chris's personal use of AI tools(12:24) The significance of DeepSeek and China's AI capabilities(17:05) The main players in the Chinese AI space(18:34) A case for Huawei as a full-stack player(20:33) LLM price trends, and why DeepSeek isn't assured to win emerging markets(22:19) Key drivers of software success, and how that might translate to AI(24:42) US AI market: Chris's insights on who will gain dominance(27:38) The concept of sovereign AI models and their viability(32:33) Trump vs. Biden on AI policy(34:52) Progress in diversifying semiconductor manufacturing(37:04) The challenges facing Intel and its future(38:55) What to watch for in the semiconductor race, and China’s move towards self-sufficiency(45:09) The advanced packaging trend(46:34) Solving for increased energy needs(50:05) The implications of the Stargate project, and what we still don’t know(52:44) The motivation behind Silicon Valley empire builders(56:10) AI's unique appeal to tech leaders' ambitions(58:03) Final meditations—Follow Chris MillerLinkedIn: https://www.linkedin.com/in/chris-miller-93004923/Twitter: https://x.com/crmiller1Website: https://www.christophermiller.net/—Resources and episode mentions—Books—• Chip War: The Fight for the World's Most Critical Technology: https://www.amazon.com/Chip-War-Worlds-Critical-Technology/dp/1982172002• Isaac Newton: https://www.amazon.com/Isaac-Newton-James-Gleick/dp/1400032954• A Brief History of Intelligence: Evolution, AI, and the Five Breakthroughs That Made Our Brains: https://www.amazon.com/Brief-History-Intelligence-Humans-Breakthroughs/dp/0063286343/For a full list of resources and episode mentions, please visit: https://thegeneralist.substack.com/p/the-semiconductor-century-with-chris-miller—Production and marketing by penname.co. For inquiries about sponsoring the podcast, email jordan@penname.co.
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    1 hr and 4 mins
  • How Anduril Is Reimagining the Defense Industry: Faster Tech, Ethical AI, and a New Kind of Deterrence | Trae Stephens (Co-Founder & Executive Chairman, Anduril)

    How Anduril Is Reimagining the Defense Industry: Faster Tech, Ethical AI, and a New Kind of Deterrence | Trae Stephens (Co-Founder & Executive Chairman, Anduril)
    May 20 2025
    What happens when you apply Silicon Valley’s speed and innovation to reinvent defense technology? Trae Stephens, co-founder of Anduril, is running that experiment in real-time. His company creates software-driven, hardware-enabled autonomous systems designed to transform national security capabilities amid growing global tensions.In today's episode, Trae and I dive deep into the ethics of warfare, technology's evolving role in national defense, the complexities of Great Power conflict with China, and how Trae’s personal faith shapes his vision for responsible innovation.We explore:• An overview of Anduril's mission and platform• A look at the "Four Americas" and why we need a strong military• How Trae uncovered gaps in intelligence that led to Anduril’s founding• The “don’t work at Anduril” campaign and how transparency filters talent• A glimpse at Anduril’s reading list and the case for organizational reading lists• An overview of Lattice, the software behind every platform Anduril builds• Why too much innovation can be a problem• How Anduril took over the IVAX project from Microsoft• Why single domain defense companies won’t win• An overview of Just War Theory, and how it guides Anduril’s mission• How the U.S. is stacking up against China’s intelligence and military• How Anduril’s mission is compatible with Trae’s faith• Lessons from Peter Thiel, Alex Karp, and Palmer Luckey• And much more!—Transcript: https://thegeneralist.substack.com/p/how-anduril-is-reimagining-the-defense-industry-trae-stephens—Thank you to the partners who make this possibleVanta: Automate compliance and simplify security.WorkOS: The modern identity platform for B2B SaaS.Brex: The banking solution for startups.—Timestamps(00:00) Intro(04:33) An overview of Anduril(05:31) The surprising way Trae got into Georgetown(11:58) Trae’s work with computational linguistics(13:37) “The four Americas” and why we need a strong military(16:05) How Trae uncovered gaps in intelligence and military that prompted Anduril’s founding(20:49) Why the incentive structure in the defense industry wasn’t working(23:08) An overview of Anduril’s leadership(25:53) The first Anduril office and how they approach hiring(31:13) The Anduril reading list(34:23) Anduril’s building philosophy, and the software behind all their products(38:45) How Anduril partners with DOD to understand what to build(41:21) Why too much innovation is not sellable(45:29) How Anduril took over the IVAS program from Microsoft(47:57) The future of weaponry(51:26) Anduril’s growth strategy: buying and building(55:02) The single domain companies Trae is excited about(58:44) How the US stacks up against China(1:05:20) Trae’s thoughts on conflict resolution and the current administration’s approach(1:08:14) How Anduril’s work in Europe may change(1:09:37) Why Trae believes his work aligns with his faith(1:12:39) An overview of “Just War Theory”(1:15:38) Lessons from Peter Thiel, Alex Karp, and Palmer Luckey(1:19:05) Final meditations—Follow Trae StephensX: https://x.com/traestephensLinkedIn: https://www.linkedin.com/in/trae-stephens-485a811/—Resources and episode mentions—Books—• Hillbilly Elegy: A Memoir of a Family and Culture in Crisis: https://www.amazon.com/Hillbilly-Elegy-Memoir-Family-Culture/dp/0062300547• The Looming Tower: Al-Qaeda and the Road to 9/11: https://www.amazon.com/Looming-Tower-Al-Qaeda-Road-11/dp/1400030846• Impro: Improvisation and the Theatre 1st Edition: https://www.amazon.com/Impro-Improvisation-Theatre-Keith-Johnstone/dp/0878301178• The Kill Chain: Defending America in the Future of High-Tech Warfare Hardcover: https://www.amazon.com/Kill-Chain-Defending-America-High-Tech/dp/031653353X...Resources continued at: https://thegeneralist.substack.com/p/how-anduril-is-reimagining-the-defense-industry-trae-stephens—Production and marketing by penname.co. For inquiries about sponsoring the podcast, email jordan@penname.co.
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    1 hr and 27 mins
  • The Substack Playbook: Inside The $650M Platform Rewriting Media, Trust, and Creator Economics | Chris Best & Hamish McKenzie (Co-Founders)

    The Substack Playbook: Inside The $650M Platform Rewriting Media, Trust, and Creator Economics | Chris Best & Hamish McKenzie (Co-Founders)
    May 6 2025
    In a world where attention is fragmented and algorithms rule the content landscape, Chris Best and Hamish McKenzie are taking a radically different approach with Substack. Rather than chasing clicks, Substack focuses on a simple yet powerful idea: creators should own their work and make money directly from their audience through paid subscriptions. With over 5 million paid subscriptions and tens of millions of active readers, Substack has turned this model into a transformative force in media.In this episode, Chris and Hamish unpack how they’re reshaping creator economics, navigating AI’s role in creativity, and enabling a new era for writers, from serialized fiction to short-form video. Their bet? That if content adds real value—whether it educates, entertains, or helps people earn—audiences will pay for it.In our conversation, we explore:• How Substack grew from a simple newsletter tool to a multi-format media platform with 5 million+ paid subscriptions• Why the "soul connection" between creators and audiences is becoming more valuable in an AI-dominated world• The inside story of Substack's clash with Elon Musk and how it ultimately strengthened their platform• Why the ceiling for great writing and culture might be much higher than we're currently imagining• How Substack's subscription model creates dramatically better economics for creators than ad-supported platforms• Chris's "grand unified theory" for how AI will influence content creation and consumption• Why their short-form content isn't just a "sticky trick" but a pathway to deeper engagement and discovery• The future of traditional prestige media brands• Much more—Thank you to the partners who make this possibleVanta: Automate compliance and simplify security.Brex: The banking solution for startups.WorkOS: The modern identity platform for B2B SaaS.—For a full transcript of the episode, please visit: https://thegeneralist.substack.com/p/the-substack-playbook—Timestamps(00:00) Intro(05:27) An overview of Substack and its current scale(06:53) The origin story of Substack(19:20) Finding the first believers(24:17) Successful fiction on Substack, and why there’s potential for much more(29:09) The different mediums available on Substack(32:27) How Substack’s feed differs from social media(37:33) The clash with Elon Musk and Twitter/X(47:23) How Substack’s network helps creators succeed(52:07) TikTok creators moving to Substack after the ban(56:20) The future of paid media consumption(58:24) Chris's grand unified theory of AI and media(1:07:07) Substack’s AI tools(1:10:54) Why it’s hard to predict where AI is taking us next(1:13:42) Advice for traditional media institutions(1:16:48) Final meditations—Follow Chris BestX: https://x.com/cjgbestLinkedIn:https://www.linkedin.com/in/cjgbest/—Follow Hamish McKenzieX: https://x.com/hamishmckenzieLinkedIn: https://www.linkedin.com/in/hamishmckenzie/—Resources and episode mentions—Books—• The Anxious Generation: How the Great Rewiring of Childhood Is Causing an Epidemic of Mental Illness: https://www.amazon.com/Anxious-Generation-Rewiring-Childhood-Epidemic/dp/0593655036• The Canterbury Tales: https://www.amazon.com/Canterbury-Tales-Geoffrey-Chaucer/dp/0140424385—People—• Jairaj Sethi on LinkedIn: https://www.linkedin.com/in/jairaj-sethi/• Andrew Chen on LinkedIn: https://www.linkedin.com/in/andrewchen/• Mike Kerns on LinkedIn: https://www.linkedin.com/in/mike-kerns-63219/• Patrick Collison on LinkedIn: https://www.linkedin.com/in/patrickcollison/—Other resources—• Substack: https://substack.com/• Kik: https://kik.com/• Listicle: https://en.wikipedia.org/wiki/Listicle• The dress: https://en.wikipedia.org/wiki/The_dress• Craigslist: https://www.craigslist.org/...Resources continued at: https://thegeneralist.substack.com/p/the-substack-playbook—Production and marketing by penname.co. For inquiries about sponsoring the podcast, email jordan@penname.co.
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    1 hr and 26 mins
  • Lessons from 20 Years of Venture Capital: Roelof Botha (Managing Partner and Steward at Sequoia Capital)

    Lessons from 20 Years of Venture Capital: Roelof Botha (Managing Partner and Steward at Sequoia Capital)
    Apr 29 2025
    Sequoia Capital is synonymous with outstanding performance, backing companies like Apple, Google, Airbnb, and Stripe. In today’s episode, I chat with Roelof Botha, Sequoia’s Managing Partner, about what it takes to see the future first, capitalize on it intelligently once it arrives, and help founders build enduring companies. Roelof is especially well-placed to discuss such matters. Not only has Sequoia navigated more than 50 years of market cycles, Roelof has personally spent more than 20 years helping shape the firm’s unique approach. From honing a philosophy rooted in clear thinking and long-term vision to asking the tough question of "What would you do with only 12 months of runway?" Roelof breaks down the mindset that’s helped Sequoia and its founders thrive, and what others can learn from it. In our conversation, we explore:• The psychological biases that most frequently derail investors• Why the first-mover advantage is often a disadvantage in technology • Why excess funding often undermines innovation• The story of PayPal's near-death experience and how it sparked its most critical innovations• How Roelof’s training as an actuary shaped his long-term thinking • How Sequoia maintains investment discipline through market cycles • Why they don’t use the word “deal” at Sequoia • How the US can maintain the lead in the AI race• The thinking behind the Sequoia Capital Fund and the firm’s organizational structure • And much more—Thank you to the partners who make this possibleBrex: The banking solution for startups.WorkOS: The modern identity platform for B2B SaaS.Explo: Customer-facing analytics for any platform.—For a full transcript of the episode, please visit: https://thegeneralist.substack.com/p/lessons-from-20-years-of-vc-roelof-botha—Timestamps(00:00) Intro(04:50) Roelof on the AI bubble(07:26) Sequoia’s Monday tracker and investment tools(09:25) AI's role in business growth(11:55) The challenge of spotting unicorns in a climate of rapid growth(14:48) Roelof’s critique of capital-heavy AI startups(19:30) A glimpse at how partners work at Sequoia(21:43) A lesson from PayPal(24:09) Roelof’s interest in decision-making and biases(27:19) Two key biases: loss aversion and anchoring(30:55) Examples of anchoring with Square and Twitter(36:30) The case for long-term thinking(41:00) Sequoia’s culture and commitment to winning(48:38) What Sequoia looks for in founders(51:39) How new technology enables less technical founders to succeed(54:06) Why AI may favor incumbents over startups(57:12) Where the US stands in the AI race(1:01:16) The risks of government overspending(1:03:54) Sequoia’s journey from idea to IPO(1:10:44) How Sequoia uses AI(1:15:05) Final meditationsPerformance numbers shared in this interview are as of March 24, 2025. Past performance is not indicative of future performance.—Follow Roelof BothaX: https://x.com/roelofbothaLinkedIn: https://www.linkedin.com/in/roelofbotha/—Resources and episode mentions—Books—• Decisive: How to Make Better Choices in Life and Work: https://www.amazon.com/Decisive-Make-Better-Choices-Life/dp/0307956393/• Leading: Learning from Life and My Years at Manchester United: https://www.amazon.com/Leading-Learning-Years-Manchester-United/dp/0316268100• A Tale of Two Cities: https://www.amazon.com/Tale-Two-Cities-Penguin-Classics/dp/0141439602• Man’s Search for Meaning: https://www.amazon.com/Mans-Search-Meaning-Viktor-Frankl/dp/0807014273/r—People—• Don Valentine: https://en.wikipedia.org/wiki/Don_Valentine• Daniel Kahneman: https://www.nobelprize.org/prizes/economic-sciences/2002/kahneman/facts/• Brian Chesky on X: https://x.com/bchesky...Episode resources continued at: https://thegeneralist.substack.com/p/lessons-from-20-years-of-vc-roelof-botha—Production and marketing by penname.co. For inquiries about sponsoring the podcast, email jordan@penname.co.
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    1 hr and 21 mins
  • Shrinking the Gap Between Sci-Fi and Sci-Fact: Josh Wolfe (Co-Founder of Lux Capital)

    Shrinking the Gap Between Sci-Fi and Sci-Fact: Josh Wolfe (Co-Founder of Lux Capital)
    Apr 15 2025
    Josh Wolfe is a co-founder of Lux Capital, where he funds the kinds of ventures that change everything: think gene-edited pig organs and technology that lets you “record” smells. His approach? Relentless curiosity. He reads dozens of newspapers daily to identify patterns, always staying a few steps ahead. In this episode of The Generalist, Josh shares how his firm backs companies that don’t just predict the future, but create it.In our conversation, we explore:• The revolutionary development of genetically modified pig organs being transplanted into humans and what this means for the future of organ transplantation.• The recent achievement of "teleporting smell" across space and why computers that can replicate scents will open up entirely new industries.• Why Lux is investing in the search for real-life "X-Men" — genetic outliers in isolated populations whose DNA could lead to life-saving medical advancements.• How Josh evaluates macro trends to make smarter micro investment decisions and why ignoring the big picture is a mistake.• The three tech sectors that Josh believes will define the geopolitical balance in the decades ahead.• How Josh stays current on macroeconomic trends.• Much more—Thank you to the partners who make this possibleBrex: The banking solution for startups.WorkOS: The modern identity platform for B2B SaaS.Generalist+: Essential intelligence for modern investors and technologists.—For a full transcript of the episode, please visit: https://thegeneralist.substack.com/p/shrinking-the-gap-between-sci-fi-and-sci-fact-josh-wolfe—Timestamps(00:00) Intro(04:38) A brief overview of Josh’s work at Lux Capital (05:57) The science fiction to science fact pipeline (09:11) Xenotransplantation(12:10) Proven transplantations with modified pig kidneys, and what’s next (15:38) Ethical questions around xenotransplantation (17:48) Lux Capital’s investment in eGenesis(19:34) The theory of persistent cellular memory (23:35) Why eGenesis began with kidneys(24:30) Digitizing smell(32:24) Commercializing digital olfaction technology(38:26) The potential applications for a “Shazam for smell” (43:16) Variant Bio’s work studying genetic outliers (52:00) Variant Bio's two primary clinical focuses(53:46) How Josh stays current on macroeconomic trends(59:44) Josh’s thoughts on the critical areas the U.S. should invest in(1:14:00) How to win the talent war(1:18:53) Final meditations—Follow Josh WolfeX: https://x.com/wolfejoshLinkedIn: https://www.linkedin.com/in/josh-wolfe-7883/—Follow Mario GabrieleNewsletter: https://thegeneralist.substack.com/LinkedIn: https://www.linkedin.com/in/mariogabriele/—Resources and episode mentions—Books—• 20,000 Leagues Under the Sea: https://www.amazon.com/000-Leagues-Under-Wordsworth-Classics/dp/1853260312• War of the Worlds: https://www.amazon.com/War-Worlds-H-G-Wells/dp/8175992824/• In Search of Lost Time: https://www.amazon.com/Search-Lost-Time-Library-Classics/dp/0812969642• Perfume: The Story of a Murderer: https://www.amazon.com/Perfume-Story-Murderer-Patrick-Suskind/dp/0375725849/• Poor Charlie's Almanack: The Wit and Wisdom of Charles T. Munger: https://www.amazon.com/Poor-Charlies-Almanack-Charles-Expanded/dp/1578645018—Other Resources—• eGenesis: https://egenesisbio.com/• Xenotransplantation: https://egenesisbio.com/xenotransplant/• Surgeons Transplant Engineered Pig Kidney Into Fourth Patient: https://www.nytimes.com/2025/02/07/health/fourth-pig-kidney-transplant.html• CRISPR: https://www.genome.gov/genetics-glossary/CRISPR• Can an Organ Transplant Change Someone’s Personality? https://www.psychologytoday.com/us/blog/the-leading-edge/202402/do-organ-transplants-cause-personality-change-in-recipients#...Episode resources continued at: https://thegeneralist.substack.com/p/shrinking-the-gap-between-sci-fi-and-sci-fact-josh-wolfe—Production and marketing by penname.co. For inquiries about sponsoring the podcast, email jordan@penname.co.
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    1 hr and 27 mins
  • How AI Will Enhance Human Potential, Not Replace It: Reid Hoffman

    How AI Will Enhance Human Potential, Not Replace It: Reid Hoffman
    Apr 8 2025
    Science fiction has long warned of AI's dark side. Think: Robots turning against us, surveillance, and lost agency. But in this episode of The Generalist, Reid Hoffman, co-founder of LinkedIn and AI pioneer, shares a more hopeful future. His book Superagency argues for AI optimism, grounded in real-world experience. We talk about how AI can fuel creativity and how to ensure technology works for us, not the other way around.We explore:• Why Reid wrote Superagency—and his belief that AI leads to more human agency, not less• The philosophical questions raised by AI’s reasoning—can machines truly think, or are they just mimicking us?• How generative AI promotes collaboration and creativity over passive consumption• Preserving humanity's essence as transformative technologies like gene editing and neural interfaces become mainstream• Reid’s optimistic take on synthetic biological intelligence as a symbiotic relationship• How AI agents can actually deepen human friendships rather than replace them• A glimpse at how Reid uses AI in his daily life• Reid’s “mini-curriculum” on science fiction and philosophy—two essential lenses for understanding AI’s potential• And much more—Thank you to the partners who make this possibleVanta⁠: Automate compliance and simplify security.Brex⁠: The banking solution for startups.WorkOS⁠: The modern identity platform for B2B SaaS.—For a full transcript of the episode, please visit: ⁠https://thegeneralist.substack.com/p/how-ai-will-enhance-human-potential-reid-hoffman⁠—Timestamps(00:00) Intro(06:10) Why Reid wrote Superagency(11:30) Reid AI—and using tech to highlight human agency(13:55) The book Amusing Ourselves to Death, and the pros and cons of any new technology(18:55) A brief overview of Reid’s career(25:16) An explanation of Reid’s belief system as a ‘mystical atheist’ (27:47) Reid’s term ‘homo techne’ and how technology makes us more human(33:54) Preserving genetic diversity to safeguard humanity(39:05) Reid’s optimistic take on synthetic biological intelligence(42:34) Why Reid wants more optimistic science fiction(45:40) The value of literature—and potential future mediums for creatives(49:12) The importance of thoughtful regulation(59:35) AI’s impact on human friendships(1:03:49) Platforms for AI agents (1:05:50) How Reid uses AI in his daily life (1:09:28) Final meditations—Books• Superagency: What Could Possibly Go Right with Our AI Future: ⁠https://www.amazon.com/Superagency-Could-Possibly-Right-Future-ebook/dp/B0D886ZQHY⁠• Impromptu: Amplifying Our Humanity Through AI: ⁠https://www.amazon.com/Impromptu-Amplifying-Our-Humanity-Through/dp/B0BYLSCPPV⁠• 1984: ⁠https://www.amazon.com/1984-Signet-Classics-George-Orwell/dp/0451524934⁠• Amusing Ourselves to Death: Public Discourse in the Age of Show Business: ⁠https://www.amazon.com/Amusing-Ourselves-Death-Discourse-Business/dp/014303653X⁠• Brave New World: ⁠https://www.amazon.com/Brave-New-World-Aldous-Huxley/dp/0060850523⁠• On Bullshit: ⁠https://www.amazon.com/Bullshit-Harry-G-Frankfurt/dp/0691122946⁠• Culture series: ⁠https://www.amazon.com/Iain-M-Banks-Culture-anniversary/dp/0356502090/⁠• Klara and the Sun: ⁠https://www.amazon.com/Klara-Sun-Ishiguro-Kazuo/dp/0571364888⁠?• Ulysses: ⁠https://www.amazon.com/Ulysses-James-Joyce/dp/0679722769⁠…For a complete list of books and all other resources mentioned in this episode, check out the show notes at: ⁠https://thegeneralist.substack.com/p/how-ai-will-enhance-human-potential-reid-hoffman⁠—Follow Reid Hoffman• Website: ⁠https://www.reidhoffman.org/⁠• X: ⁠https://x.com/reidhoffman⁠• LinkedIn: ⁠https://www.linkedin.com/in/reidhoffman/⁠• Podcast: ⁠https://www.possible.fm/⁠—Follow Mario Gabriele• Newsletter: ⁠https://thegeneralist.substack.com/⁠• LinkedIn: ⁠https://www.linkedin.com/in/mariogabriele/⁠—Production and marketing by ⁠penname.co⁠. For inquiries about sponsoring the podcast, email jordan@penname.co.
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    1 hr and 15 mins