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Ever wondered why your symptoms seem to flare right before your period? The answer lies in the fascinating and often overlooked connection between female hormones and histamine intolerance.

Women are twice as likely to suffer from histamine-related issues compared to men, and it's not by chance. Your body's natural hormone fluctuations create a perfect storm for histamine sensitivity. When estrogen rises before ovulation and menstruation, it activates mast cells throughout your body, triggering histamine release. Meanwhile, this same estrogen suppresses DAO, the enzyme responsible for breaking down histamine in your digestive system. Adding to this challenging cascade, progesterone—which normally helps stabilize mast cells—drops dramatically before your period, removing one of your body's natural protective barriers.

My own journey with histamine intolerance took an unexpected turn after my complete hysterectomy in 2017. Following surgery, I experienced months of symptom relief that seemed miraculous—energy returned, digestion normalized, and food sensitivities disappeared. This personal revelation led me to investigate the hormone-histamine connection that affects so many women during various life stages including perimenopause, menopause, pregnancy, and throughout the monthly cycle.

Understanding this connection isn't just fascinating—it's empowering. Once you recognize how your hormones influence histamine levels, you can begin to anticipate symptom patterns, identify triggers, and work with your body's natural rhythms rather than against them. Share your own experience with hormones and histamine by emailing Teresa@histaminehealthcoach.com, and don't miss our previous episodes on DAO (episode 7) and HNMT (episode 10) to deepen your understanding of histamine metabolism.