In Episode 5 of the Content Crib Podcast, we sit down for a candid, conversational discussion with Preston Alexander, a seasoned healthcare entrepreneur and content creator. Preston shares firsthand insights into the most challenging aspects of today’s healthcare system and introduces his exciting new endeavor aimed at transforming that landscape. The tone is informal and engaging as we explore how Preston’s journey – from managing massive healthcare portfolios to launching his own startup – has shaped his mission to make healthcare better for everyone.

Preston Alexander brings a wealth of experience in healthcare and a passion for change. He spent over a decade in leadership roles at global healthcare companies, where he managed more than $100 million in business and gained a deep understanding of how large hospital systems operate. He eventually left the corporate world to found a medical device company (One Degree Medical), which he successfully grew and sold before turning his focus to helping others innovate in healthcare. Today, Preston serves as an advisor and consultant to healthcare companies of all stages, driven by a passion for creating a more affordable, accessible, and equitable healthcare system.

Aside from building businesses, Preston is also an accomplished writer who has chronicled the business of healthcare through his popular newsletter The Healthcare Breakdown. He writes extensively about health systems and financial fundamentals, breaking down complex industry topics into no-nonsense insights that equip clinicians and entrepreneurs to enter the business side of medicine. This content-driven approach has become a cornerstone of his new endeavor. The Healthcare Breakdown has already attracted over 11,000 subscribers – a testament to the impact of Preston’s content. Industry peers have even praised it as “a great digest of the healthcare business”. By openly sharing his knowledge and stories, Preston has built a dedicated community around healthcare innovation, which in turn fuels his business mission.

In This Episode

• From Corporate Leader to Founder: We discuss Preston’s personal journey, including his leap from being a product manager in a global firm to becoming a startup founder. He shares lessons learned in building One Degree Medical and the experience of successfully exiting his company, along with how that experience reshaped his perspective on innovation in healthcare.
• A New Endeavor for Change: Preston introduces his latest venture – an initiative born from his desire to help clinicians and health entrepreneurs “take back” the business of healthcare. After selling his startup, he’s now focused on empowering others to launch and grow solutions that make care better. He often says his goal is to help clinicians get into business so they can take back healthcare, highlighting his commitment to clinician-led change.
• Content Creation as a Catalyst: A major theme is how Preston’s talent for content creation has amplified his impact. He reveals how writing and sharing weekly breakdowns of the healthcare industry not only educated his audience but also sharpened his own expertise. By building a platform through his writing, Preston has enhanced his credibility and opened new doors for collaboration. The success of The Healthcare Breakdown – with thousands of readers and growing – illustrates how quality content can drive business growth and community-building.