What if I told you that heart disease—the #1 cause of death—is completely preventable and even reversible? That the key to living a longer, healthier life isn’t just in your genes, but in the choices you make every single day? In this episode of Legends of Longevity, we dive into the cutting-edge science of anti-aging with renowned cardiologist Dr. Giovanni Campanile. From reversing plaque buildup to using AI-driven diagnostics, cold therapy, and the power of nitric oxide, Dr. Campanile reveals the ultimate blueprint for optimizing heart health and longevity. This is an episode you can’t afford to miss!

Joseph Ence welcomes Dr. Giovanni Campanile, a leader in preventative cardiology, to discuss how cardiovascular health is at the core of longevity. A former interventional cardiologist, Dr. Campanile has shifted his focus from treating heart disease with stents to preventing and reversing it through advanced testing, lifestyle changes, and cutting-edge therapies.

They explore how personalized nutrition, exercise, stress management, and novel treatments like hyperbaric oxygen, red light therapy, and cryotherapy can drastically reduce cardiovascular risk. Dr. Campanile also explains the science behind AI-assisted heart health diagnostics and shares real-life case studies proving that heart disease can be reversed.

This episode is your ultimate guide to protecting your heart, living longer, and thriving well into old age. Don’t just add years to your life—add life to your years. Hit play now!

✅ Heart disease is preventable & reversible – Advanced lipid testing reveals hidden risks beyond cholesterol levels.

✅ Inflammation is a major culprit – Reducing chronic inflammation through diet, exercise, and therapies like saunas can significantly lower heart disease risk.

✅ Cold exposure & heat therapy work wonders – Cryotherapy and saunas improve circulation, reduce inflammation, and promote longevity.

✅ AI is revolutionizing cardiology – Cutting-edge imaging and diagnostics now allow for earlier detection and better prevention strategies.

✅ Your gut microbiome matters – The bacteria in your gut can influence cholesterol metabolism, inflammation, and overall longevity.

✅ Genetics are not destiny – Lifestyle changes can override genetic predispositions and dramatically lower heart disease risk.

✅ Lessons from Blue Zones – Social connection, natural movement, and nutrient-dense foods are common among the world’s longest-living populations.

00:00 – 🔥 Intro Hook: The Secret to Reversing Heart Disease

02:11 – Meet Dr. Giovanni Campanile

05:31 – Why Cardiovascular Health is Key to Longevity

06:50 – The Role of Apolipoprotein B in Heart Disease

09:46 – Understanding the Epidemic of Heart Disease

14:47 – Nutrition’s Role in Heart Health: The Egg McMuffin Effect

16:48 – Measuring and Reversing Atherosclerosis

21:11 – The Power of AI in Predicting Heart Disease

28:10 – The Impact of Nitric Oxide and Endothelial Function

32:08 – The Gut-Heart Connection and Advanced Lipid Testing

35:51 – The Role of PCSK9 Inhibitors in Lowering Risk

37:55 – Personalizing Diet and Cardiovascular Risk Factors

44:08 – AI and Imaging: CLEARly Test for Detecting Vulnerable Plaque

46:37 – The Importance of Exercise for a Healthy Heart

49:32 – Cutting-Edge Longevity Therapies: Red Light, Sauna, and Fasting

55:53 – Case Study: Reversing Coronary Artery Disease

57:21 – The Future of Anti-Aging and Cardiovascular Medicine

01:02:03 – Nutrient Deficiencies and the Need for Supplements

01:07:02 – The Science of Cryotherapy and Cold Exposure

01:15:13 – Lessons from Blue Zones: Diet, Community, and Respect

01:18:49 – The Gut Microbiome and the Future of Medicine

01:24:32 – Final Thoughts: Prevention, Reversal, and Living Well