Key clinical takeaways:

• MMR status should be tested in all patients at diagnosis and upon disease progression to guide personalised treatment decisions

• ICI and ChT combination, including with maintenance olaparib, demonstrates benefits in patients with non-dMMR advanced/recurrent endometrial cancer, with greater efficacy observed in dMMR populations

• Lenvatinib plus pembrolizumab is a viable option not only as 2nd line therapy but also as 1st line treatment for patients with non-dMMR advanced/recurrent endometrial cancer who have progressed after prior systemic therapy in any setting

• Shared decision-making, supported by patient education, is essential for optimising treatment outcomes

The treatment landscape for advanced and recurrent endometrial cancer (EC) is evolving, with molecular classification playing a key role in guiding decisions. In this podcast, Prof. Xavier Matias-Guiu (Pathologist) and Dr Jurjees Hasan (Medical Oncologist) discuss the latest advancements in personalised treatment approaches for EC.

Key topics include:

• The role of molecular classification in guiding treatment selection and testing strategies

• Treatment options for patients with pMMR status

• Effective patient communication for shared decision-making

Tune in for expert insights and practical guidance to optimise treatment strategies in advanced and recurrent EC

You can also watch a video of the experts in conversation and download the accompanying transcript on our website: https://cor2ed.com/obstetrics-gynecology-connect/programmes/endometrial-cancer-molecular-classification-treatment-decisions/

Or watch on YouTube: https://youtu.be/KvYIB7PBpyQ

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This content is intended for healthcare professionals only.

The medical experts in this podcast are expressing their own views and not those of COR2ED, Supporters or their institution. This programme has been sponsored by Eisai Europe Limited ("Eisai"). Eisai has had no input on the educational content of, or speakers involved in this podcast.

This podcast is developed by cor2ed.com

Published February 2025

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Appropriate management of postpartum hemorrhage (PPH) requires prompt diagnosis and treatment. However, there's some debate on various PPH prevention and management strategies and the corresponding scientific evidence. What do you believe is the right strategy to prevent and treat PPH?

In this third episode of a four-part podcast series on severe PPH, Prof. Loïc Sentilhes (Professor of Obstetrics and Gynecology, Chairman of the Gynecology and Obstetric Department at Bordeaux University Hospital, France) and Prof. Christian von Heymann (Chief Physician of the Clinic for Anesthesia, Intensive Care Medicine and Pain Therapy and Medical Director at the Vivantes Clinic in Friedrichshain, Germany) discuss various topics on the treatment of severe PPH, and we also explore the scientific evidence combined with the clinical experience of the experts.

With Dr Homa Ahmadzia as moderator, experts share learnings from their own clinical practice and explore: (1) The role of prophylactic tranexamic acid to prevent PPH, (2) When to initiate blood transfusions or other blood products, (3) Pharmacological treatments and their use and (4) The importance of multidisciplinary collaboration in the management in PPH.

Prefer to watch as well as listen?

Watch a video of the experts in conversation and download the full transcript on the COR2ED website: https://cor2ed.com/obstetrics-gynecology-connect/programmes/severe-pph-treatments/

Or go to the video on YouTube: https://youtu.be/e9hEa5tczZo?si=H6jrK6PwIsXtQZuZ

We are pleased to share that this podcast is endorsed by UNITE GLOBE (UNITed Efforts to reduce GLobal OBstetric HemorrhageE). You can find out more about UNITE GLOBE at https://ahmadziaresearch.smhs.gwu.edu/unite-globe

The medical experts in this podcast are expressing their own views and not those of COR2ED, supporters, or their institution. This podcast is supported by an Independent Medical Education Grant from Novo Nordisk.

This educational podcast is developed by cor2ed.com.

COR2ED Medical Education: In this podcast, Prof. Andra H. James (Professor Emeritus of Obstetrics and Gynecology, Division Maternal Fetal Medicine, Duke University Hospital, Durham, North Carolina, US) and Dr Maria Elisa Mancuso (Senior Haematology Consultant at the Center for Thrombosis and Hemorrhagic Diseases of IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy) discuss various treatment options for severe postpartum haemorrhage (also called PPH).

Experts discuss what causes PPH and how to determine the risk before and during labour with algorithms and other helpful tools. The discussion moves to when haematologic expertise is required and how collaboration can be optimized to provide the best care for patients. Furthermore, the experts share their learnings from clinical practice through discussion of specific patient cases, including patients with and without underlying bleeding disorders, as well as where haemostatic agents fit in the protocol.