This episode dissects a narrative review article examining the complex relationship between two frequently confused causes of dizziness: Persistent Postural-Perceptual Dizziness (PPPD) and Vestibular Migraine (VM). The author reviews literature from 2000 to 2025 to compare the diagnostic criteria, underlying causes (pathophysiology), and appropriate treatments for each condition.

Moreno- Ajona D. Persistent postural- perceptual dizziness versus vestibular migraine: A narrative review. Headache. 2025;00:1-9. doi:10.1111/head.15078

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This episode does a deep dive on a research report detailing a randomized controlled trial (RCT) designed to assess physical therapy interventions for chronic rotator cuff-related shoulder pain (RCRSP). The study compared the effectiveness of muscle strengthening exercises alone versus a protocol combining strengthening with proprioceptive exercises in 70 patients over an eight-week period.

Buccioli ALB, Oliveira AS, Vendramim ACC, Scaglione GD, Roy JS, Rossi DM. Proprioceptive exercises combined with strengthening exercises are not superior to strengthening exercises alone for shoulder pain and disability in individuals with chronic rotator cuff-related shoulder pain: a randomized controlled trial. J Orthop Sports Phys Ther. 2025;55(7):495-511. Epub 16 June 2025. doi:10.2519/jospt.2025.13097

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This episode dissects an article that investigates the relationship between creative experiences and brain health using quantitative metrics known as brain clocks to measure deviations from chronological age, or brain age gaps (BAGs). The research utilized a large sample of participants across various creative domains—including dance, music, visual arts, and video games—to show that creative experiences are associated with delayed brain aging (lower negative BAGs).

Coronel-Oliveros C, Migeot J, Lehue F, Amoruso L, Kowalczyk-Grębska N, Jakubowska N, et al. Creative experiences and brain clocks. Nat Commun. Published online October 3, 2025. doi:10.1038/s41467-025-64173-9.

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This episode does a deep dive on the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE) trial. This analysis investigated the effect of long-term caloric restriction (CR) on biological aging measures in healthy, non-obese adults, aligning with the geroscience hypothesis that slowing molecular aging can delay chronic disease. Researchers used DNA methylation (DNAm) algorithms, specifically focusing on the DunedinPACE measure of the pace of aging, as well as the PhenoAge and GrimAge clocks, to assess the impact of a two-year CR intervention.

Waziry R, Ryan CP, Corcoran DL, Huffman KM, Kobor MS, Kothari M, et al. Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial. Nat Aging. 2023. doi:10.1038/s43587-022-00357-y

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This episode does a deep dive into a systematic review examining the relationship between creatine and cognitive function specifically in older adults. The authors conducted a comprehensive search across eight databases to systematically examine current literature on this topic.

Marshall S, Kitzan A, Wright J, Bocicariu L, Nagamatsu LS. Creatine and cognition in aging: a systematic review of evidence in older adults. Nutr Rev. 2025;00(00):1-12. doi:10.1093/nutrit/nuaf135

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This episode dissects an academic systematic review with meta-analysis published in the journal Sports concerning the impact of caffeine consumption before late afternoon or evening training on athletes' subsequent sleep. The research synthesizes findings from ten studies to examine changes in both objective sleep parameters (like sleep efficiency and total sleep time) and subjective sleep experiences.

Kocak A, Georgousopoulou E, Knight-Agarwal CR, Matthews R, Minehan M. The Effect of Consuming Caffeine Before Late Afternoon/Evening Training or Competition on Sleep: A Systematic Review with Meta-Analysis. Sports. 2025;13:317. doi:10.3390/sports13090317

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This episode does a deep dive on a network meta-analysis evaluating the comparative effectiveness and optimal dosage of various exercise types—specifically aerobic training (AT), resistance training (RT), flexibility training (FT), and combined training (AT+RT)—for reducing depressive symptoms in children and adolescents. Overall, the study aims to provide evidence-based guidance for developing targeted clinical and public health strategies to manage adolescent depression through physical activity.

Cao X. Comparative effects of exercise type and dose on depression in children and adolescents: a network meta-analysis. Front Psychol. 2025;16:1632111. doi:10.3389/fpsyg.2025.1632111.

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This episode does a deep dive into a clinical trial article, "Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction." The study, known as the COLCOT trial, was a randomized, double-blind, placebo-controlled trial involving 4745 patients who had recently suffered a myocardial infarction, aiming to evaluate the effectiveness of low-dose colchicine, an anti-inflammatory medication, in preventing subsequent ischemic cardiovascular events.

Tardif JC, Kouz S, Waters DD, Bertrand OF, Diaz R, Maggioni AP, et al. Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction. N Engl J Med. 2019;381(26):2497-2505. doi:10.1056/NEJMoa1912388.

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