This episode does a deep dive on a research report detailing a randomized controlled trial (RCT) designed to assess physical therapy interventions for chronic rotator cuff-related shoulder pain (RCRSP). The study compared the effectiveness of muscle strengthening exercises alone versus a protocol combining strengthening with proprioceptive exercises in 70 patients over an eight-week period.

Buccioli ALB, Oliveira AS, Vendramim ACC, Scaglione GD, Roy JS, Rossi DM. Proprioceptive exercises combined with strengthening exercises are not superior to strengthening exercises alone for shoulder pain and disability in individuals with chronic rotator cuff-related shoulder pain: a randomized controlled trial. J Orthop Sports Phys Ther. 2025;55(7):495-511. Epub 16 June 2025. doi:10.2519/jospt.2025.13097

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This episode dissects an article that investigates the relationship between creative experiences and brain health using quantitative metrics known as brain clocks to measure deviations from chronological age, or brain age gaps (BAGs). The research utilized a large sample of participants across various creative domains—including dance, music, visual arts, and video games—to show that creative experiences are associated with delayed brain aging (lower negative BAGs).

Coronel-Oliveros C, Migeot J, Lehue F, Amoruso L, Kowalczyk-Grębska N, Jakubowska N, et al. Creative experiences and brain clocks. Nat Commun. Published online October 3, 2025. doi:10.1038/s41467-025-64173-9.

Follow Dr. Anthony Novello, PT, DPT

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This episode does a deep dive on the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE) trial. This analysis investigated the effect of long-term caloric restriction (CR) on biological aging measures in healthy, non-obese adults, aligning with the geroscience hypothesis that slowing molecular aging can delay chronic disease. Researchers used DNA methylation (DNAm) algorithms, specifically focusing on the DunedinPACE measure of the pace of aging, as well as the PhenoAge and GrimAge clocks, to assess the impact of a two-year CR intervention.

Waziry R, Ryan CP, Corcoran DL, Huffman KM, Kobor MS, Kothari M, et al. Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial. Nat Aging. 2023. doi:10.1038/s43587-022-00357-y

Follow Dr. Anthony Novello, PT, DPT

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