Buckle up for a trip (pun intended) into the midlife brain. This week we sit down with neuroscientist Dr. Grace Blest-Hopley to connect the dots between cannabinoids, psychedelics, trauma, and the menopause transition. We cover CBD/THC for sleep, anxiety, pain, and inflammation; how the endocannabinoid system works, and how psychedelics like psilocybin act on serotonin pathways, reduce neuroinflammation, and promote neuroplasticity—potentially countering some brain changes seen with estrogen loss. We also dig into trauma (including why PTSD risk and expression differ by sex), the importance of set, setting, and skilled facilitation, who should not use psychedelics, the legal/clinical landscape, and much more. Curious about midlife brain health and whether these therapies are worth exploring? This one’s for you.

Dr. Grace Blest-Hopley is a neuroscientist with 12 years experience researching cannabis, cannabinoids, and psychedelics. Grace completed her PhD in Neuroscience at King's College London and currently serves as the Chief Scientific Officer at NWPharma Tech. She is the Research Director at Heroic Hearts Project, a charity that supports combat veterans with mental health challenges resulting from trauma and is also the founder of Hystelica, a community focused on understanding women's biology for safe and effective psychedelic use. In addition to her research and professional roles, she has served as an officer in the British Army Reserve. Dr. Blest-Hopley advocates for the therapeutic potential of these substances and strives to advance the field of psychedelic research. Her work contributes to promoting a better understanding of women's biology in relation to psychedelics. You can learn more about her and her work at hystelica.com

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Growing up in sport, this week’s guest was often told her body wasn’t “right”—too muscular, not tall enough, never thin enough—and those messages followed her into adulthood through the pressures of work, marriage, motherhood, and loss. Her turning point came in a hotel gym, where she discovered the power of fueling well, eating enough protein, and lifting heavy. What began as a shift from self-medicating with alcohol to self-empowering with weights eventually led her to bodybuilding, a sport that both celebrates and sometimes complicates women’s bodies. We dig into how eating more can transform health and performance, what it really takes to step on stage, how perimenopause shows up with rage, panic, and fatigue, and why muscle is the “metabolic 401k” every woman needs. This is a conversation about rewriting the script—replacing “small and skinny” with “strong and powerful”—and embracing the bodies we were meant to have. You can learn more about her work at AnneMarieChaker.com

Anne Marie Chaker is a veteran journalist and professional bodybuilder. During her two-decade career at The Wall Street Journal, she held reporting jobs all over the paper, from the Journal’s regional editions to the Spot News Desk during the September 11 attack. She has covered everything from politics to news events, consumer trends, education, the workplace, and the major sociological shifts of our time. Chaker lives in the Washington, D.C., area with her partner, Rick; daughters Juliette and Sylvie; and their overeager pup, Ninja. Her latest book is LIFT: How Women Can Reclaim Their Physical Power and Transform Their Lives.

Resources:

LIFT: How Women Can Reclaim Their Physical Power and Transform Their Lives here

Anne Marie Chaker Substack here

I Never Thought I’d Write This: I Am a Female Bodybuilder, Wall Street Journal

I’m 50, in Perimenopause—and About to Compete as a Pro Bodybuilder, Daily Beast

At 65, Diane Grim was the oldest woman competing at the Western States 100–widely considered one of the toughest organized trail runs in the United States–this year. It was her first ever 100 miler and she didn’t even start running till she was in her 50s, but as she says, every mile, every step is a gift, so why not? She didn’t have the day she hoped for, but she left filled with pride, hope of better days to come, and a newfound goal to wrap up some unfinished business. This week she shares her successes, failures, her crazy training days during menopause, and why you’re never too old to be young again.

Diane is a former bike racer turned trail runner at age 50, and she hasn’t literally or figuratively backpedaled since! Diane’s trail friends call her “MacGyver” thanks to her love of problem-solving and making things on the fly. She runs by the motto: If you can’t run fast, run smart. Every mile is a gift! Anywhere outside is Diane’s happy place and you can find her hammock camping, landscaping, building stuff or running through the woods like a kid! Diane is so grateful to be running Western States, proudly sponsored by the HOKA Outreach Program.

Resources:

https://www.instagram.com/p/DLYYfiPPtw0/

https://trailsisters.net/women-of-wser/#:~:text=the%20Panelists%20%26%20Host-,Diane%20Grim,t%20run%20fast%2C%20run%20smart.

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