Could saying no actually be your best longevity strategy?

Blair LaCorte reveals why avoiding over-optimization and focusing on system biology, compassion, and purpose instead leads to authentic biosynergy and lasting vitality.

Blair LaCorte is a dynamic business executive whose career spans entertainment, aviation, AI, technology, aerospace, consulting, investing & military logistics. He has held CEO & C-level roles at leading companies like PRG, XOJET/Vista, TPG, Autodesk & Oracle, while also taking startups such as AEye Technologies & VerticalNet to IPO. Currently an astronaut-in-training with Virgin Galactic & Vice Chairman of the Buck Institute, Blair continues to drive innovation, growth & global impact.

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• Tech is for control, not a cure all Forgetting biology leads to problems, not progress
• Over optimizing health with gadgets causes new problems Step back & look at the whole picture
• Scientific knowledge & personal belief both affect your biology & well being more than most realize
• Staying healthy is better than only reacting to sickness Small daily choices matter more than silver bullets
• Focus on what works for you Test, observe, & stick with what fits your life & makes you feel good
• Relationships lower stress & boost your immune system Loneliness is a major health risk at any age
• Some stress helps growth Chronic unbroken stress harms your body Find ways to activate & calm yourself
• Knowing health tips isn’t enough Build habits you enjoy, ideally with friends or community support, for lasting results
• No two people are alike Track your own changes & work out routines & diets that fit you specifically
• Modern testing makes it easier to spot issues early Keep personal health records to track your biomarkers over time

04:19 Why Technology Alone Won’t Save Your Health

21:17 The Real Framework for Habit Change That Works

28:50 What Truly Multiplies Healthspan Results

36:44 Practical Ways to Strengthen Connection & Reduce Stress

46:28 How to Personalize Health in a Complex World

• Watch it on YouTube: https://youtu.be/U2QuhPEugq4
• Full episode show notes: outliyr.com/223

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Ever feel mentally foggy even after resting?

Bill McKenna of Cognitive Movement shares simple eye movements, spinning, and body-awareness exercises that bioharmonize your brain, sharpen focus, and boost decision-making, without drugs or endless study sessions.

Bill’s journey from high-thrill pursuits to spiritual exploration led him to develop a method for lasting transformation. After a near-death experience, he immersed himself in the mind-body connection & co-created Cognomovement with Liz. His work blends resilience, insight & a passion for helping others unlock their potential.

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• Holding your device at eye level supports happier brain chemicals & reduces sadness linked to looking down
• Time spent looking down at phones closely matches rising rates of depression & anxiety, especially in teens
• Where you move your eyes activates different brain areas—looking up sparks creativity, down triggers sadness
• Moving your eyes through certain positions acts like a workout for your mind, boosting different aspects of IQ
• Simple movements like spinning in a chair stimulate your brain’s processing speed, attention, & working memory
• Open peripheral vision improves mood, awareness, & reduces conflict in relationships & daily life
• Physical & emotional injuries show up the same way in brain scans & block certain mental functions
• Even just a few minutes of the right brain exercises daily create lasting improvements in focus & cognitive ability
• Children’s instinct to spin, run, & use their vision in different ways helps their brains develop properly
• Walking labyrinths or figure eights balances brain hemispheres, inspires new ideas, & solves tough problems

02:13 How Eye Position & Movement Influence Brain Function

20:39 Brain-Boosting Exercises You Can Do Anywhere

30:10 How to Identify & Correct Brain Weaknesses

41:51 Real-Life Results From Cognitive Movement

3:17 How to Start & Keep Progressing

• Watch it on YouTube: https://youtu.be/oTWWugDMntw
• Full episode show notes: outliyr.com/223

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Think your gut health only affects digestion?

From fermented foods and targeted probiotics to peptides like BPC157, Dr. Vincent Pedre shares practical ways to rebuild microbiome balance and boost overall performance.

Dr. Vincent Pedre is the Medical Director of Pedre Integrative Health & CEO of Happy Gut Life, with over 25 years of clinical experience as a Functional Medicine-certified practitioner & gut biohacker. He’s the bestselling author of Happy Gut & he GutSMART Protocol, a 14-day personalized gut-healing plan. His latest creation, Happy Gut Coffee, is a clean, toxin-free brew that supports gut health & boosts energy from the first sip.

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• Antibiotics in childhood cause long-term gut problems. Fixing your gut requires targeted effort, no matter when the damage began
• Certain gut infections like E. coli trigger autoimmune responses, leading to chronic gut issues like IBS & leaky gut
• Taking multi-strain probiotics while on antibiotics helps your gut recover faster than waiting until after the antibiotics
• Regularly eating fermented foods strengthens the immune system, reduces inflammatory markers, & boosts gut microbiome diversity
• Short-term carnivore diets help people with severe bloating, SIBO, or trouble digesting vegetables, giving their gut a break
• Reintroduce vegetables slowly, beginning with fermented ones—they’re easier to digest & support rebuilding your gut flora
• Oral peptides like BPC157 & lorazatide repair tight junctions, reduce food sensitivities, & speed up gut healing
• Many chronic health issues trace back to hidden parasites, even if you don’t have gut symptoms Proper testing is key
• Short chain fatty acid butyrate made by gut bacteria heals the colon, reduces inflammation, & helps the brain
• Choose organic, mold-free coffee to protect your gut from pesticides, mycotoxins, & microplastics while getting gut-healthy polyphenols

01:21 How Antibiotics Damage the Gut

10:04 How to Restore Your Gut After Taking Antibiotics

18:11 Safely Reintroducing Foods & Fermented Products for Gut Healing

26:03 Dr. Pedre’s CARE Gut Healing System

35:46 The Connection Between Gut Health & Mitochondria

• Watch it on YouTube: https://youtu.be/m5lvpsituus
• Full episode show notes: outliyr.com/222

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Standard blood tests barely scratch the surface.

Ryan Smith shares how TruDiagnostic’s TruAge & TruHealth tests use over 1,700 biomarkers from just a drop of blood to measure biological age, hormone health, immunity & more. Go beyond standard labs & start bioharmonizing with cutting-edge precision so you can make decisions that actually impact how you feel & age.

Ryan Smith studied Biochemistry at Transylvania University before founding Tailor Made Compounding, which became one of the fastest-growing healthcare companies in the U.S. After exiting in 2020, he launched several ventures, including TruDiagnostic, a CLIA-certified lab specializing in methylation-based diagnostics for longevity & preventive health.

TruDiagnostic leads the field with one of the largest private epigenetic databases, over 13,000 patients, & active participation in 30+ clinical research studies. Ryan remains a key figure in advancing functional medicine through innovative health data solutions.

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• Biological age gives a clearer picture of health risk than birthdate by showing how your body is actually aging
• Lifestyle basics like exercise, clean eating, stress reduction & social connection remain top tools for aging well
• Some biological age tests are more reliable thanks to stronger prediction power & actionable results
• Longevity interventions can now be ranked using technology that tracks measurable improvements over time
• Leading tests don’t just score your age but give clear next steps to improve healthspan & lifespan
• DNA methylation data offers biomarker proxies that sometimes outperform traditional blood tests
• Methylation-based tests bring better precision & consistency than standard lab results affected by daily shifts
• Immune system strength plays a major role in aging by influencing inflammation & clearing damaged cells
• Supplement & lifestyle tracking tools now show whether specific changes are actually improving key health markers
• TruAge tests work well for most while biohackers may benefit more from deeper panels like the TruHealth test

3:29 What Biological Age Really Tells You

10:12 Inside TruDiagnostic’s Testing Framework

11:39 Key Lifestyle & Supplement Insights from the Data

15:10 How to Interpret Your Report & Take Action

30:12 Understanding Your Immune & Metabolic Health

45:29 Practical Application & Future of Epigenetic Testing

• Watch it on YouTube: https://youtu.be/MykPl4fZ3Sc
• Full episode show notes: outliyr.com/221

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Think more data means better health?

Dr. Zain Hakeem challenges the obsession with endless biomarkers & breaks longevity down to its core drivers. You’ll see how effect size, simplicity, consistency, beat the latest trends & how to bioharmonize your lifestyle around what truly works.

Dr. Hakeem is a dual board-certified physician in Internal Medicine & Pediatrics, with a background in philosophy from LSU & a medical degree from Texas College of Osteopathy. He practices both primary & hospital medicine, blending acute care insight with preventative strategies.

He’s the creator of the Rx-Bayes app, which helps doctors interpret diagnostic accuracy through a statistical lens. On his YouTube channel, he breaks down health misinformation, explores true longevity optimization, & discusses why meaning is essential to living well.

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• Focus on five key drivers like VO2 max, strength, social connections, not smoking & blood pressure instead of chasing 100+ biomarkers
• Prioritize interventions with the biggest impact on lifespan rather than spending energy on minor or unproven strategies
• Avoid mistaking correlation for causation by digging deeper into the real reasons behind trends
• Recognize that the number of social interactions directly influences mortality risk & shouldn’t be overlooked
• Improve VO2 max & strength through exercise to dramatically cut mortality risk even with simple changes
• Avoid Goodhart’s Law by targeting true overall strength instead of isolated metrics like grip strength
• Choose practices with real effects backed by evidence rather than wasting time chasing small wins
• Optimize both quantity & quality of life by aiming to enjoy more years not just add them
• Understand that both too much & too little sleep carry risks while exercise may be more influential than sleep alone
• Rely on interventions supported by strong human evidence like clinical trials & Bradford Hill criteria

3:36 5 Longevity Drivers That Matter Most

10:07 What the Research Gets Wrong

25:19 VO2 Max, Strength & Social Health Deep Dive

40:02 Exercise, Adaptation & Anti-Fragility

47:18 The Limits of Stacking & Testing

1:08:21 Redefining Longevity, Sleep & What Really Matters

• Watch it on YouTube: https://youtu.be/YhcdonAJm8M
• Full episode show notes: outliyr.com/220

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How many meaningful months do you actually have left?

Karen Salmansohn confronts the fear of death head-on & shows how it can fuel joy, growth & focus. This conversation covers mortality-based mindset shifts, bioharmonizing daily routines, & creating identity habits that connect your actions to your deeper purpose.

Karen Salmansohn is a best-selling author & Behavioral Change Expert known for blending psychology, neuroscience & bold humor to help people live with greater intention. With over two million books & courses sold, she’s the founder of NotSalmon.com, a personal development hub with 1.5 million followers, and has appeared on Oprah & in Psychology Today.

Her unique background in advertising & design fuels her witty, research-backed content, including bestsellers like How to Be Happy, Dammit. Karen empowers others to break free from autopilot & create more purposeful, fulfilling lives.

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• Stop living on autopilot by focusing on presence over just going through the motions
• Use mortality awareness to fuel urgent positive action instead of fear or paralysis
• Make decisions through the lens of your future self to avoid regret later
• Write your eulogy now to clarify what truly matters & aim for meaningful goals
• Replace your to-do list with a to-die-for list filled with lasting experiences & deep relationships
• Anchor daily habits to core values since identity creates lasting behavior change
• Bridge the gap between your current self & eulogy self with intentional daily actions
• Use tools like marble jars & life maps to make time visible & inspire better choices
• Apply the greater-than sign to choose long-term fulfillment over short-term comfort
• Swap bad habits with better stories & behaviors that support who you want to become

04:01 Living a “To Die For Life” With Intention

06:38 Using Death Awareness to Design a Better Life

15:35 Building Identity-Based Habits That Stick

36:41 Practical Tools to Anchor New Behavior

48:54 Overcoming Resistance, Self-Doubt & Old Patterns

• Watch it on YouTube: https://youtu.be/RTHQ4rFZPu0
• Full episode show notes: outliyr.com/219

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Tired of surface-level wellness routines that never stick?

Dr. Amy Albright reveals how real transformation starts with tuning into your body’s signals. From EEG brain retraining & intuitive journaling to Chinese medicine & autoimmune protocols, this episode outlines a grounded path to clarity, inner peace & next-level health.

Dr. Amy Albright is a pioneer in human potential, integrating neuroscience, business strategy, health, & spirituality to help individuals & organizations thrive. As CEO & co-founder of Holon, she partners with Dr. Drew Pierson to deliver cutting-edge neurofeedback programs that accelerate cognitive, emotional, physical, & spiritual growth.

Her innovative methods help visionary leaders achieve clarity, resilience, & alignment with their core values. Through advanced brain training & transformational practices, Dr. Amy empowers people to unlock their highest potential.

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• Prioritize more & better sleep to drive growth, change & true high performance
• Tailor nutrition to what your body actually feels best with, not just trends or generic advice
• Blend scientific data with intuition because gut feelings & deeper truths matter just as much as numbers
• Find what’s optimal for you since every brain works differently & high performance depends on personal alignment
• Understand the amygdala’s full role as it boosts joy, memory & focus, not just fear responses
• Let go of pain & trauma quickly with skilled support & the right tools since healing doesn't need to be slow
• Train your nervous system to relax deeply so vacation-level calm becomes your new normal
• Listen to intuitive micro-signals in your body since small feelings guide massive life changes
• Use handwritten morning journaling to connect with inner clarity & surface hidden answers
• Remember your worth goes beyond numbers because your spirit, not just your data, defines your potential

06:15 Dr. Amy Albright’s Holistic Approach to Brain Health

16:02 Where Science Meets Spirituality

18:55 Using Technology for Transformation at Holon

41:48 Enhancing Brain Health with Biochemistry, Brainwaves & Intuition

47:13 Real Brain-Based High Performance

01:01:14 Tools for Emotional Healing, Nervous System Reset & Inner Alignment

• Watch it on YouTube: https://youtu.be/DiEBO2GNvRs
• Full episode show notes: outliyr.com/218

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