Contributor: Travis Barlock, MD

Educational Pearls:

What is an internal jugular catheter (IJ) and when do we use it?

• IJs are catheters that can be placed in either the left or the right internal jugular vein to provide central venous catheter (CVC) access. CVCs can be placed in other locations other than the internal jugular vein (i.e. subclavian vein or femoral veins).
• IJs are used when the patient may require long-term venous access or have to receive hyperosmolar solutions (such as solutions with high glucose content for parenteral nutrition); solutions with extreme pHs (<5 or >9); or vesicant drugs (drugs that can cause tissue necrosis with extravasation).
• They are not to be confused with EJs (external jugular vein catheters) which can be placed in difficult to peripherally catheterize patients. EJs function similarly to a peripheral IV.
• The advantage of IJs is their location in larger veins brings them closer to direct access to the heart (i.e. the right internal jugular vein will provide immediate/quicker access to the right atrium to the heart.)

What are concerns of using a right internal jugular catheter versus one in the left?

• The right internal jugular vein provides quick access to the heart via the right atrium, making it ideal in critically ill patients who may require vasopressor support.
• However it is also the site commonly used for additional cannulation procedures such as hemodialysis, pulmonary artery pressure measurements, extracorporeal membrane oxygenation (ECMO) and transvenous pacemaker placement.
• These procedures are not uncommon in critically ill patients who also required a CVC for initial hemodynamic support via vasopressors.
• Gharaibeh et al. found that patients who received a right IJ and hemodialysis had a higher need for re-insertion of the hemodialysis catheter (40% compared to 2.6% in the left IJ group).
• Furthermore, it was found that with a right IJ, hemodialysis catheters had to be exchanged by a guidewire in 23% of those with a right IJ as opposed to 0.9% in the left IJ group (a guidewire exchange is often considered a salvage technique to try and maintain access).

Big Takeaway?

• If you are able to obtain an IJ on the right, you can likely obtain one on the left, and if considering longitudinal care for your patient, consider obtaining an IJ on the left to allow for future critical access in the right IJ.

References

1. Gharaibeh KA, Abdelhafez MO, Guedze KEB, Siddiqi H, Hamadah AM, Verceles AC. Impact of initial jugular vein insertion site selection for central venous catheter placement on hemodialysis catheter complications. Journal of Critical Care. 2025;87:155011. doi:10.1016/j.jcrc.2024.155011
2. Gallieni M, Pittiruti M, Biffi R. Vascular access in oncology patients. CA: A Cancer Journal for Clinicians. 2008;58(6):323-346. doi:10.3322/CA.2008.0015

Summarized by Dan Orbidan, OMS2 | Edited by Dan Orbidan & Jorge Chalit, OMS4

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Contributor: Aaron Lessen, MD

Educational Pearls:

How long do we need to watch patients with a presumed overdose who were treated with naloxone in the field?

• A 2025 study in the Annals of Emergency Medicine took a look at this question
• Methods
  • Prospective, multi-institutional cohort study
  • Included ED patients with suspected acute opioid overdose with biologic testing to confirm substances.
  • This paper performed a secondary analysis evaluating the risk of "delayed intubation," defined as intubation occurring >4 hours after ED arrival.
• Results
  • 1,591 patients with presumed opioid overdose were included.
  • Delayed intubation occurred in only 9 patients (0.6%).
  • 8 of the 9 cases had non-respiratory causes contributing to intubation.
  • Only 1 patient had respiratory-related deterioration, presenting with respiratory acidosis after receiving 6.4 mg naloxone prior to intubation.
• Key Takeaway
  • Delayed respiratory deterioration requiring intubation after 4 hours of ED monitoring is extremely rare, suggesting prolonged monitoring may not be necessary for most stabilized overdose patients.

How else can we mitigate risk?

• Give patients take-home naloxone at discharge and educate them on how to use it (See Episode 673: Leaving the ED with Naloxone).

When are naloxone drips necessary?

• If a patient requires repeated naloxone boluses, consider a drip
• To get the dose, take the total naloxone dose that restored adequate breathing and give two-thirds of that dose per hour
• Typically these patients are admitted to the ICU

References

1. McCabe DJ, Gibbs H, Pratt AA, Culbreth R, Sutphin AM, Abston S, Li S, Wax P, Brent J, Campleman S, Aldy K, Falise A, Manini AF; ToxIC Fentalog Study Group. Risk of Delayed Intubation After Presumed Opioid Overdose in the Emergency Department. Ann Emerg Med. 2025 Jun;85(6):498-504. doi: 10.1016/j.annemergmed.2025.01.022. Epub 2025 Mar 4. PMID: 40047773; PMCID: PMC12955731.

Summarized and edited by Jeffrey Olson MS4

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Contributor: Travis Barlock, MD

Educational Pearls:

• D-dimer: fibrin degradation product used to evaluate for clot formation and breakdown
  • Threshold: <500ng/mL rules out venous thromboembolism in low risk patients
  • Elevated D-dimer indicates recent or ongoing intravascular coagulation and fibrinolysis
• YEARS score: algorithm to assess PE risk using three clinical criteria
  • Criteria: signs of DVT, hemoptysis, and PE as the most likely diagnosis
  • YEARS score of 0 with D-dimer <1000 ng/mL: PE can be ruled out
  • YEARS score of ≥1 with D-dimer <500 ng/mL: PE can be ruled out
  • A study found that YEARS score accurately predicted the presence or absence of PE in 80% of enrolled patients with 90% sensitivity and 65% specificity
• D-dimer may also help exclude aortic dissection: Aortic Dissection Detection Risk Score (ADD-RS)
  • When ADD-RS = 0 or 1 and D-dimer <500ng/mL: aortic dissection may be ruled out in low-risk patients
  • When ADD-RS >1, patients are considered high probability for aortic dissection and CT should be performed

References

1. Fayiad, H., Moussa, H., Nosair, Y. et al. Predictive accuracy of years score in diagnosis of pulmonary embolism. Egypt J Bronchol 18, 18 (2024). https://doi.org/10.1186/s43168-024-00269-y
2. Weitz JI, Fredenburgh JC, Eikelboom JW. A Test in Context: D-Dimer. J Am Coll Cardiol. 2017 Nov 7;70(19):2411-2420. doi: 10.1016/j.jacc.2017.09.024. PMID: 29096812.
3. Yichao Ma,Zhenjiang Ding,Yunong Zhao,Paijiao Zhang,Bo Du,Ye Shen,Junmei Hu,Luqi Zhu,Honghong Zhao,Chunrong Jin,Yuhong Wang,Lizhen Gao,Research progress on multi-marker detection technology for cardiovascular diseases (review), Journal of Electroanalytical Chemistry, 1008, (119969), (2026).

Summarized by Meg Joyce, MS2 | Edited by Meg Joyce & Jorge Chalit, OMS4

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