Lessons from Rwanda’s Marburg Virus Outbreak and Building Resilient Systems in Global EM.

Hosts:
Tsion Firew, MD
Brian Gilberti, MD

• The Threat: Marburg Virus Disease is from the same family as Ebola and has historically had a reported fatality rate as high as 90%.
• The Outbreak (Sept. 2024): Rwanda declared an MVD outbreak. The initial cases involved a miner, his pregnant wife (who fell ill and died after having a baby), and the baby (who also died).
• Healthcare Worker Impact: The wife was treated at an epicenter hospital. Eight HCWs were exposed to a nurse who was coding in the ICU; all eight developed symptoms, tested positive within a week, and four of them died.
• The Turning Point: The outbreak happened in city referral hospitals where advanced medical interventions (dialysis, mechanical ventilation) were available.
  • Rapid Therapeutics Access: Within 10 days of identifying Marburg, novel therapies (experimental drugs and monoclonal antibodies) and an experimental vaccine were made available through diplomacy with the US government/CDC and agencies like WHO, Africa CDC, CEPI and more.
• The Outcome: This coordinated effort—combini...

We review the diagnosis, risk stratification, & management of acute pulmonary embolism in the ED.

Hosts:
Vivian Chiu, MD
Brian Gilberti, MD

• Definition: Obstruction of pulmonary arteries, usually from a DVT in the proximal lower extremity veins (iliac/femoral), but may be tumor, air, or fat emboli.
• Incidence & Mortality: 300,000–370,000 cases/year in the USA, with 60,000–100,000 deaths annually.
• Mantra: “Don’t anchor on the obvious. Always risk stratify and resuscitate with precision.”
• Risk Factors: Broad, including older age, inherited thrombophilias, malignancy, recent surgery/trauma, travel, smoking, hormonal use, and pregnancy.

• Presentation: Highly variable, showing up as anything from subtle shortness of breath to collapse.
• Acute/Subacute: Dyspnea (most common), pleuritic chest pain, cough, hemoptysis, and syncope. Patients are likely tachycardic, tachypneic, hypoxemic on room air, and may have a low-grade fever.
• Chronic: Can mimic acute symptoms or be totally asymptomatic.
• Pulmonary Infarction Signs: Pleuritic pain, hemoptysis, and an effusion.
• High-Risk Red Flags: Signs of hypotension (systolic blood pressure < 90 mmHg for over 15...

We break down pneumothorax: risks, diagnosis, and management pearls.

Hosts:
Christopher Pham, MD
Brian Gilberti, MD

• Secondary pneumothorax
  • Trauma: rib fractures, blunt chest trauma (as in the case).
  • Iatrogenic: central line placement, thoracentesis, pleural procedures.
• Primary spontaneous pneumothorax
  • Young, tall, thin males (10–30 years).
  • Connective tissue disorders: Marfan, Ehlers-Danlos.
  • Underlying lung disease: COPD with bullae, interstitial lung disease, CF, TB, malignancy.
• Technically, anyone is at risk.

• Typical PTX presentation: Dyspnea, chest pain, pleuritic discomfort.
• Exam clues: unilateral decreased breath sounds, focal tenderness/crepitus.
• Red flags (suggest tension PTX):
  • JVD
  • Tracheal deviation
  • Hypotension, shock physiology
  • Severe tachycardia, hypoxia
• Differential diagnoses:
  • Pulmonary: asthma, COPD, pneumonia, pulmonary edema (SCAPE), ILD, infections.
  • Cardiac: ACS, CHF, pericarditis.
  • PE and other acute causes of dyspnea.

• Bloodwork: limited role, except type & screen if intervention likely.
• EKG: reasonable given chest pain/shortness of br...

Angioedema – Recognition and Management in the ED

Hosts:
Maria Mulligan-Buckmiller, MD
Brian Gilberti, MD

Angioedema = localized swelling of mucous membranes and subcutaneous tissues due to increased vascular permeability.

Triggers increased vascular permeability → fluid shifts into tissues.

• Histamine-mediated (anaphylaxis)
  • Associated with urticaria/hives, pruritus, and redness.
  • Triggered by allergens (foods, insect stings, medications).
  • Rapid onset (minutes to hours).
• Bradykinin-mediated
  • Hereditary angioedema (HAE): C1 esterase inhibitor deficiency (autosomal dominant).
  • Acquired angioedema: Associated with B-cell lymphoma, autoimmune disease, MGUS.
  • Medication-induced: Most commonly ACE inhibitors; rarely ARBs.
  • Typically lacks urticaria and itching.
  • Gradual onset, can last days if untreated.
• Idiopathic angioedema
  • Unknown cause; diagnosis of exclusion.

• Swelling
  • Asymmetric, non-pitting, usually non-painful.
  • May involve lips, tongue, face, extremities, GI tract.
• Respiratory compromise
  • Upper airway swelling → stridor, dyspnea, sensation of throat closure.
  • Airway obstruction is the most feared complication.
• Abdominal manifestations

Granulomatosis with Polyangiitis (GPA) – Recognition and Management in the ED

Hosts:
Phoebe Draper, MD
Brian Gilberti, MD

• A vasculitis affecting small blood vessels causing inflammation and necrosis
• Affects upper respiratory tract (sinusitis, otitis media, saddle nose deformity), lungs (nodules, alveolar hemorrhage), and kidneys (rapidly progressive glomerulonephritis)
• Can lead to multi-organ failure, pulmonary hemorrhage, renal failure

• Chronic sinus symptoms
• Hemoptysis (especially bright red blood)
• New pulmonary complaints
• Renal dysfunction
• Constitutional symptoms (fatigue, weight loss, fever)

• CBC, CMP for anemia and AKI
• Urinalysis with microscopy (hematuria, RBC casts)
• Chest imaging (CXR or CT for nodules, cavitary lesions)
• ANCA testing (not immediately available but important diagnostically)

• Stable patients: Outpatient workup, urgent rheumatology consult, prednisone 1 mg/kg/day
• Unstable patients: High-dose IV steroids (methylprednisolone 1 g daily x3 days), consider plasma exchange, cyclophosphamide or rituximab initiation, ICU admission

• Goodpasture syndrome (anti-GBM antibodies)
• TB, fungal infections
• Lung malignancy
• Other vasculitides (EGPA, MPA, lupus)

We discuss capacity assessment, patient autonomy, safety, and documentation.

Hosts:
Anne Levine, MD
Brian Gilberti, MD

• Arises frequently in the ED, even when not formally recognized
• Carries both legal implications and ethical weight
• Failure to appropriately assess capacity can result in:
  • Forced treatment without justification
  • Missed opportunities to respect autonomy
  • Increased risk of litigation and poor patient outcomes

• Capacity is:
  • Decision-specific: varies based on the medical choice at hand
  • Time-specific: can fluctuate due to medical conditions, intoxication, delirium
• Distinct from competency, which is a legal determination
• Relies on a patient’s ability to:
  • Understand relevant information
  • Appreciate the consequences
  • Reason through options
  • Communicate a clear choice

• Intoxicated patient with head trauma refusing CT
  • Unreliable neuro exam
  • Potentially time-sensitive intracranial injury
• Elderly patient with sepsis refusing admission due to caregiving responsibilities
  • Balancing autonomy vs. beneficence
• Patient with gangrenous diabetic foot refusing surgery
  • Demonstrates logic and consistency despite high-risk decision

• Understanding
  • Can the patient explain:
  • Their condition
  • Recommended treatments
  • Risks and benefits
  • Alternatives and outcomes?
• Sample prompts: