Episodes

  • Psilocybin, LSD & Marijuana: Ranking Drugs for Longevity (Part 2)

    Psilocybin, LSD & Marijuana: Ranking Drugs for Longevity (Part 2)
    Sep 11 2025
    Should I try shrooms for science? In part two of three of our series investigating drugs for longevity, I’m putting psilocybin, LSD and DMT under the microscope - and revealing some pretty exciting research that connects psychedelics to longer lifespans. We’ll also talk about weed, and what the data says about marijuana for longevity. Study Links: Psilocybin for Cancer Patients LSD: Longevity in Worms Cannabis Use Disorder Increases Mortality Risk Marijuana Increases Epigenetic Aging Marijuana’s Impacts on Sleep Improving Sleep with Medical Cannabis Hosts: Bryan Johnson: Blueprint Founder Kate Tolo: Blueprint Co-Founder Dr. Mike Mallin: Lead Physician for Bryan Johnson Connect: X: https://x.com/bryan_johnson YouTube: https://www.youtube.com/@BryanJohnson Instagram: https://www.instagram.com/bryanjohnson TikTok: https://www.tiktok.com/@_bryan_johnson_ Chapters: 00:00 - Introduction 01:52 - First Experiences With Drugs 05:42 - Psychedelics in Society 13:29 - Psilocybin, LSD & DMT 34:35 - Marijuana 50:53 - Longevity Rankings
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    56 mins
  • Ketamine & Cocaine: Ranking Drugs for Longevity (Part 1)

    Ketamine & Cocaine: Ranking Drugs for Longevity (Part 1)
    Sep 4 2025
    Can doing lines help you live longer? That depends on what you’re taking. In this three-part series, I’m ranking drugs based on their ties to longevity, starting with ketamine and cocaine. I tested ketamine on myself to study its impacts on the brain — here’s what we found. Study Links: Ketamine’s Effects on Epigenetic Age Extending Ketamine’s Therapeutic Window Ibogaine Therapy for PTSD Hosts: Bryan Johnson: Blueprint Founder Kate Tolo: Blueprint Co-Founder Dr. Mike Mallin: Lead Physician for Bryan Johnson Connect: X: https://x.com/bryan_johnson YouTube: https://www.youtube.com/@BryanJohnson Instagram: https://www.instagram.com/bryanjohnson TikTok: https://www.tiktok.com/@_bryan_johnson_ Chapters: 00:00 - Introduction 03:14 - Social Norms Around Drugs 08:59 - Psychedelics as Therapy: Overview 10:20 - Cocaine 17:15 - Fentanyl Dangers 23:27 - Ketamine: Brain Impacts + Longevity 41:29 - Measuring The Impacts of Psychedelics 47:51 - Longevity Rankings: Cocaine + Ketamine
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    50 mins
  • Jesse James West on AI, Fitness & Self-Worth

    Jesse James West on AI, Fitness & Self-Worth
    Aug 28 2025
    Fitness creator Jesse James West is a natural bodybuilder who makes some of the coolest videos on YouTube for over 7 million subscribers. We’re talking about his motto of “stay relentless,” and how he balances work, health and life now that he’s newly married. Plus, he shares about the time that he also had a breakdown in Target - and how it may have saved his life. Connect with Bryan: X: https://x.com/bryan_johnson YouTube: https://www.youtube.com/@BryanJohnson Instagram: https://www.instagram.com/bryanjohnson TikTok: https://www.tiktok.com/@_bryan_johnson_ Connect with Jesse: YouTube: https://www.youtube.com/@JesseJamesWest Instagram: https://www.instagram.com/jessejameswest TikTok: https://www.tiktok.com/@jessejameswest X: https://x.com/jessejameswestt Chapters: 00:00:00 - Introduction 00:01:15 - Finding Work Life Balance 00:08:32 - Stay Relentless 00:11:01 - Jesse’s Darkest Moment + What He Learned 00:22:48 - What an AI Future Looks Like 00:27:24 - Jesse’s Health Protocol 00:34:26 - Longevity, Psychedelics, & Aliens 00:44:58 - Married Life + Family Planning 00:48:55 - Top Tips for Longevity 00:54:02 - Bodybuilding, Steroids, & Healthy Eating 00:57:23 - Jet Lag Protocol 00:59:32 - Living For Tomorrow = Living Forever 01:02:45 - Jesse’s Health Goals
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    1 hr and 4 mins
  • Don’t ‘Dye’ - Empowering Kids to Understand Health

    Don’t ‘Dye’ - Empowering Kids to Understand Health
    Aug 14 2025
    Between synthetic dyes, air pollution, and environmental toxins, kids have a lot of obstacles in the way of their health. I’m reviewing some top offenders (like synthetic dyes and added sugars) and discussing how to empower our kids to make informed choices. Study Links: Synthetic Dyes in Food & Beverages HEPA Filters in LA Schools US Kids Face Deadlier Odds Peanut Allergies & Air Pollution Hosts: Bryan Johnson: Blueprint Founder Kate Tolo: Blueprint Co-Founder Dr. Mike Mallin: Lead Physician for Bryan Johnson Connect: X: https://x.com/bryan_johnson YouTube: https://www.youtube.com/@BryanJohnson Instagram: https://www.instagram.com/bryanjohnson TikTok: https://www.tiktok.com/@_bryan_johnson_ Chapters: 00:00 - Introduction 02:20 - Synthetic Dyes + Added Sugars 14:20 - Teaching Kids About Nutrition 20:21 - Toxins, Food Allergies, & Air Quality 22:42 - Kids Health Protocol 24:24 - Screen Time, Social Media & Mental Health 26:22 - U.S. Kids Are Dying at Higher Rates 29:44 - Societal Changes for Better Health 34:41 - Empowering Kids to Make Healthy Choices
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    39 mins
  • Nobody Taught You THIS About Sex

    Nobody Taught You THIS About Sex
    Aug 7 2025
    My team and I looked into the biological effects of eating a*s and choking during sex - here’s what we found. I’m also sharing why I monitor my erections - and why this metric is critical for good health and longevity. Study Links: Choking During Sex Overnight Erections Female Erection Cycles Hosts: Bryan Johnson: Blueprint Founder Kate Tolo: Blueprint Co-Founder Dr. Mike Mallin: Lead Physician for Bryan Johnson Connect: X: https://x.com/bryan_johnson YouTube: https://www.youtube.com/@BryanJohnson Instagram: https://www.instagram.com/bryanjohnson TikTok: https://www.tiktok.com/@_bryan_johnson_ Chapters: 00:00 - Introduction 01:15 - Taboos Around Sex 04:50 - Sex is Good For You 08:33 - Choking During Sex 15:06 - Anilingus (Rimming) 22:20 - Sexual Preferences + Microbiome 25:25 - Erection Cycles: Male and Female 34:38 - We Need More Conversations About Sex
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    38 mins
  • What Stress, Burnout, and Hustle Culture Do To Your Body

    What Stress, Burnout, and Hustle Culture Do To Your Body
    Jul 31 2025
    Had I protected my body and brain, I’d be wealthier and more successful today. Culture is lying to you — you do not need to martyr yourself to be successful. Here’s how you can avoid making the same mistake I did. Study Links: Burnout + Heart Attack Risk Hours Worked + Heart Disease Sleep Deprivation in CEOs Sleep Deprivation in Judges Hosts: Bryan Johnson: Blueprint Founder Kate Tolo: Blueprint Co-Founder Dr. Mike Mallin: Lead Physician for Bryan Johnson Connect: X: https://x.com/bryan_johnson YouTube: https://www.youtube.com/@BryanJohnson Instagram: https://www.instagram.com/bryanjohnson TikTok: https://www.tiktok.com/@_bryan_johnson_ Chapters: 00:00 - Introduction 03:11 - Martyring Yourself for Success 15:50 - Study: ‘Overwork Will Kill You’ 20:04 - Sleep + Decision Making (Studies) 25:54 - Physical Fitness + Diet (Studies) 28:24 - Treating Health Like Religion 33:30 - Tips for Balancing Work and Health 43:58 - Resting Heart Rate Before Bed 47:06 - Protecting Your Agency
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    52 mins
  • These Toxins Are Silently Ruining Your Health

    These Toxins Are Silently Ruining Your Health
    Jul 24 2025
    Society is bathing us in chemicals. From wildfires to 4th of July fireworks, toxins feel inescapable. Here’s what I’m doing to limit exposure and reduce my levels. Show Links: Blueprint Food Guide: https://blueprint.bryanjohnson.com/pages/blueprint-protocol#food-guide Further Listening: “How Sauna Detoxified My Body” - Bryan Johnson Podcast “We Need to Talk About Microplastics” - Bryan Johnson Podcast Hosts: Bryan Johnson: Blueprint Founder Kate Tolo: Blueprint Co-Founder Dr. Mike Mallin: Lead Physician for Bryan Johnson Connect: X: https://x.com/bryan_johnson YouTube: https://www.youtube.com/@BryanJohnson Instagram: https://www.instagram.com/bryanjohnson TikTok: https://www.tiktok.com/@_bryan_johnson_ Chapters: 00:00 - Introduction 01:20 - Fireworks + Toxic Celebrations 12:27 - LA Wildfire Toxins 16:57 - Truth About Air Quality 21:23 - PFAS 31:49 - Reducing Toxins/PFAS 46:11 - Sauna, HBOT & Diet 50:13 - Don’t Freak Out
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    53 mins
  • How to Travel Without Wrecking Your Sleep and Brain

    How to Travel Without Wrecking Your Sleep and Brain
    Jul 17 2025
    International travel is brutal on your mind, body, and sleep. We discuss the recent data and I share my current jet lag protocol (still evolving) to help minimize the damage after long flights. Study Links: Olympic Athletes + Jet Lag: https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2022.998484/full Connect: X: https://x.com/bryan_johnson YouTube: https://www.youtube.com/@BryanJohnson Instagram: https://www.instagram.com/bryanjohnson TikTok: https://www.tiktok.com/@_bryan_johnson_ Chapters: 00:00 - Introduction 01:08 - Where’s Kate? 02:00 - Bryan’s Travel Experiment 03:44 - Debunking the ‘CEO Lifestyle’ 06:28 - Why Jet Lag Happens 08:00 - Jet Lag Recovery 14:00 - Improving Sleep 17:07 - Is Fighting Jet Lag Possible? 21:44 - Olympic Athlete Study 24:42 - Travel Rule of Thumb 33:55 - Shifting Your Mindset 35:10 - Setting Limits for Travel 44:25 - Jet Lag Protocol 50:41 - Stimulants During Travel 52:04 - Cryotherapy/Cold Therapy 53:00 - Episode Takeaways
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    59 mins