(0:00) Introducing Sir Demis Hassabis, reflecting on his Nobel Prize win

(2:39) What is Google DeepMind? How does it interact with Google and Alphabet?

(4:01) Genie 3 world model

(9:21) State of robotics models, form factors, and more

(14:42) AI science breakthroughs, measuring AGI

(20:49) Nano-Banana and the future of creative tools, democratization of creativity

(24:44) Isomorphic Labs, probabilistic vs deterministic, scaling compute, a golden age of science

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(0:00) Introducing Elon Musk, and reflecting on his DOGE experience

(2:47) Optimus: Progress and potential, the “hands problem”

(12:20) Tesla: AI5 chips, impact on FSD

(16:50) SpaceX: Vision for Starlink-enabled smartphones, $17B spectrum deal, Starship update

(26:16) xAI: Next-gen Grok models, Colossus 2, scaling laws, “Grokipedia”

(31:29) Evolving alongside AI, implosion of the West, the religion vacuum

(37:36) Understanding the universe, going to the Moon, what happens on Mars?

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(0:00) Introducing Palantir CEO Alex Karp

(1:10) Understanding Palantir's fans and haters

(8:40) Palantir’s work at the border, data collection and surveillance, built-in protections

(20:02) Israel/Palestine

(22:23) Is the West committing suicide?

(30:54) Antisemitism

(31:52) China’s strategy, dealing with cartels

(36:46) Why modern Progressivism is not progressive

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(0:00) Introducing Adena Friedman

(1:16) Nasdaq's business, expanding beyond a stock exchange

(2:44) Big announcement! Nasdaq will offer tokenized securities, crypto going mainstream, the 24/5 trading schedule

(7:21) How the IPO market can change to help companies go public faster

(13:37) Evolution of markets: predictions, options, SPVs, secondaries

(18:18) State of the stock market, role at the NY Fed, data issues at the Fed

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(0:00) Introducing Mark Cuban, sadness over Luka Doncic

(2:38) America’s broken healthcare system

(15:16) State of the two-party system

(19:24) Introducing Tucker Carlson

(20:01) The fine line between listening and pandering, is Mamdani the Trump of the Left?

(24:27) How to make Americans believe in America again

(34:12) AI job displacement

(39:29) Lightning round with Tucker: Epstein, Putin, why the West is killing itself, the SSRI epidemic, Iryna Zarutska murder

(52:54) Antisemitism and Israel

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(0:00) Introducing Secretary Wright

(1:09) Nuclear, China’s approach

(4:02) Increasing energy output, how the climate change complex slowed us down, problems with solar and wind

(11:32) Debating renewables vs nat gas and coal

(18:40) Chamath’s energy framework

(21:42) Addressing challenges: budget cuts to research labs, residential energy cost increases due to datacenter demand, speeding up nuclear development

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(0:00) Bestie intros

(0:52) Behind the scenes of the White House Tech Dinner!

(28:39) Tariff showdown headed to the Supreme Court

(42:44) Other Trump Administration legal battles

(46:58) Weak jobs report: what is the state of the economy?

(57:52) Google avoids worst-case scenario in antitrust case

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Referenced in the show:

https://x.com/EdLudlow/status/1963763066988110177

https://www.whitehouse.gov/articles/2025/09/president-trump-tech-leaders-unite-american-ai-dominance

https://www.youtube.com/watch?v=opn9soJ5TYM&t=11s

https://truthsocial.com/@realDonaldTrump/posts/115119151783895076

https://www.congress.gov/bill/94th-congress/house-bill/3884

https://www.cbo.gov/publication/61697

https://x.com/tkl_adam/status/1963961233368924464

https://www.cbsnews.com/news/jobs-report-today-august-2025-three-takeways-federal-reserve

https://www.cnbc.com/2025/09/02/google-antitrust-search-ruling.html

https://polymarket.com/event/us-recession-in-2025?tid=1757216927232

https://www.wsj.com/opinion/google-antitrust-lawsuit-artificial-intelligence-amit-mehta-doj-trump-administration-d3b675b4

(0:00) David Friedberg welcomes Senator Rand Paul: background, family, what led him to medicine first

(3:56) Career Change: Medicine to Politics

(7:03) Political Philosophy

(10:55) Trade Policy & Economic Impact

(15:52) Consequences of Tariffs

(20:43) Voting Against the One Big Beautiful Bill

(27:52) AI & the Economy

(35:10) Our Fragile Financial System

(41:22) Government Employment & Appropriate Spending

(48:18) COVID Cover Up & Dangers of Gain-of-function Research

(1:01:00) Relations with China

(1:05:52) Political Future

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