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In this special anniversary edition of the Journal Club, Ben and Daphna celebrate four years of The Incubator Podcast while diving into a compelling lineup of neonatal studies. The episode kicks off with a review of a phase 2 multicenter trial on the safety of furosemide in preterm infants at risk for BPD. Despite widespread Lasix use in NICUs, data on dosing and safety have been lacking—this study finds no significant increase in serious adverse events but emphasizes the need for larger trials to better define its role. The team then explores a study from India comparing 7- vs. 14-day antibiotic courses in culture-proven neonatal sepsis, showing that shorter courses may be safe and effective in select populations.

Additional discussions include a randomized trial from Australia evaluating “sigh breaths” during high-frequency oscillatory ventilation and their effects on lung volume and oxygenation, a study examining how kangaroo mother care boosts breast milk intake, and a large Japanese cohort study detailing neurodevelopmental outcomes of infants born at 22–31 weeks. Finally, a meta-analysis on prenatal cannabis exposure underscores risks of low birth weight and preterm birth. With depth, humor, and clarity, Ben and Daphna guide listeners through evidence that shapes neonatal care.

As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

Enjoy!