Summary

Dr Gideon Hirschfield is a leading expert in autoimmune liver diseases, including PSC, PBC, and autoimmune hepatitis. He’s helped shape how these conditions are understood and managed around the world, combining cutting-edge research with a real passion for patient care.

Today he discusses his work with autoimmune liver diseases, particularly primary sclerosing cholangitis (PSC) and autoimmune hepatitis. We discuss some key topics in PSC (including use of Ursodeoxycholic acid, cancer surveillance as well as the PSC/IBD phenotype), and Professor Hirschfield gives us a masterclass in the management of autoimmune hepatitis. He also offers advice for new hepatologists, highlighting the significance of clear diagnoses, individualized patient management, and clinical trials to drive us into the future.

As always comments, questions and feedback please send to: X: @2guystalkingit

Email: 2guystalkingit@gmail.com

Chapters

00:30 J & J Introduction

06:15 Introduction to Professor Hirschfield and Autoimmune Liver Diseases

07:41 The Role of Ursodeoxycholic Acid in PSC Management

19:06 Understanding the Pathophysiology of PSC

22:43 Cancer Surveillance in PSC Patients

28:39 The Relationship Between PSC and Inflammatory Bowel Disease

32:30 Vancomycin and PSC

36:28 Management Strategies for PSC and IBD Patients including Pouches

40:00 Management of Autoimmune Hepatitis: An Art and Science

56:30 Proactive Approaches in Primary Biliary Cholangitis (PBC) Management

1:01:05 Advice for Aspiring Hepatologists

Keywords

Hepatology, Autoimmune Liver Disease, PSC, Ursodeoxycholic Acid, Cancer Surveillance, Inflammatory Bowel Disease, Clinical Trials, Patient Care, Liver Transplantation, PSC Management, pouch studies, autoimmune hepatitis, management, PBC, hepatology, patient choices, liver transplant, treatment options, chronic diseases, clinical trials