Colorado, 1976. When Reverend Mike Fuller and his beautiful wife, Sharon, arrive in the sleepy town of Rocky Ford, local residents think something’s off about the new couple. The God-fearing minister is gruff and cold, while charismatic Sharon has her husband wrapped around her finger.

On a cold night in January 2001, the idyllic community of Dartmouth College was shattered by the discovery that two of its most beloved professors had been hacked to death in their own home. Investigators searched helplessly for clues linking the victims to their murderer or murderers. A few weeks later, across the river, in the town of Chelsea, Vermont, police cars were spotted in front of the house of a high school senior. Soon, the town discovered the incomprehensible reality that two of Chelsea's brightest and most popular sons, were now fugitives, wanted for the murders.

Best friends Daryl Barber and James Boucher were responsible, and their parents trusted them to spend Spring Break at Daytona Beach unchaperoned. When the boys missed their agreed-upon daily check-ins, their parents were disappointed. When they failed to come home on their planned return date, their parents were terrified. They could not have known that their innocent sons would encounter two violent men on the Florida coast. They could not have imagined the torture their children would endure before their bodies turned up four months later in a Florida swamp.

Brian Stidham fell in love with Tucson, Arizona, the minute he came to town. A young and talented eye surgeon, he accepted a job with an established eye surgeon to take over his pediatric patients. Brad Schwartz, the doctor who hired Brian, was ambitious and possessed surgical skills few others had. But he was a troubled man. Within a year of Stidham’s arrival in Tucson, the medical relationship would be severed by Schwartz’s personal troubles.

The names of notorious serial killers are usually well-known; they echo in the news and in public consciousness. But most people have never heard of Israel Keyes, one of the most ambitious and terrifying serial killers in modern history American Predator is the ambitious culmination of years of interviews with key figures in law enforcement and in Keyes's life, and research uncovered from classified FBI files. Callahan takes us on a journey into the chilling, nightmarish mind of a relentless killer, and to the limitations of traditional law enforcement.