Peter and Adele Robinson were dragged up by an alcoholic, violent father and a beaten mother, their childhood in Manchester preparing them only for a life of crime. Adele studies hard and makes a success of her life whilst Peter immerses himself in the murky underworld of crime, and their once close bond breaks. However, when Adele is in danger, there's only one person she can turn to...her brother.

When Julie Quinley wakes up after a night out with friends to find herself accused of murder, it proves to be only the beginning of her worst nightmare. Released by the police due to lack of evidence, Julie nevertheless faces the taunts and hostility of colleagues, as more and more people – including members of her own family – seem convinced she is a cold-hearted killer. Just when it seems as if all hope has gone, and Julie's mental state reaches rock bottom, her friend Vinny announces a breakthrough; something he has witnessed that could prove Julie's innocence once and for all.

Jane, Carly and Rose Savage are savage by name, savage by nature. Having lost their mum too young, and with a bedridden father too ill to work, the sisters learnt early to stand on their own two feet. The family's flat in the rough streets of Glasgow's Haghill is their fortress, but when Carly's ex-boyfriend Cole Alexander is released from prison, trouble soon comes knocking at their door. The Alexanders have beef with the Savages, so the girls call for back up in the shape of their uncle Eddie and his two gorgeous but dangerous sons, Harry and Dean.

Georgie Deacon thinks nothing of it when a gang of girls led by Yasmin, a member of the notorious Marx family, knock at her door and threaten to hurt her daughter—that is until her daughter doesn't return home. Detective Clark Kims ignores Georgie's plea to have the gang of girls brought in for questioning. He insists it is the work of the Kent serial killer, until Georgie realizes that the detective's daughter is part of the gang.

When respected journalist Maddy goes to interview prostitutes in a rundown Manchester pub, she doesn't reckon on attracting the attention of their ruthless pimp, Gilly. He quickly decides to use Maddy for his own gains; he just needs to work out how. In the weeks that follow, Maddy is oblivious to Gilly's growing obsession with her, particularly when she begins a romance with successful businessman Aaron. Their passionate love affair starts to dominate her life, and she finds herself losing control and alienating the people around her. As Maddy's safe and successful life starts to crumble around her.