Tiny Alpha Missiles: The Radiopharmaceutical Revolution and the Race to Decentralize Cancer Treatment
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Tiny Alpha Missiles: The Radiopharmaceutical Revolution and the Race to Decentralize Cancer Treatment
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About this listen
Dive into the atomic frontier of medicine with “Tiny Alpha Missiles: The Radiopharmaceutical Revolution and the Race to Decentralize Cancer Treatment.” From secretive Oak Ridge labs and Saul Hertz’s pioneering radioactive iodine therapy to today’s molecular “smart bombs” that fuse targeting antibodies with alpha and beta emitters like Ac‑225 and Lu‑177, this episode traces how nuclear physics met biology to transform oncology. Discover how cleavable linkers, enzyme clean‑ups, and PET-imaging companions are boosting precision and safety, why half-lives and supply chains are the new bottlenecks, and how cyclotrons, thorium-derived isotopes, and even fusion concepts aim to democratize access. It’s a fast-paced tour of history, science, and the high-stakes buildout poised to bring ultra-targeted cancer care from a few elite centers to patients everywhere.