Investigating autoimmune mechanisms underlying progressive supranuclear palsy
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Investigating autoimmune mechanisms underlying progressive supranuclear palsy
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About this listen
Welcome to the 30th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications.
This episode features a discussion with senior author Professor Gabor G Kovacs of the Brain article entitled: Midbrain cytotoxic T cells as a distinct neuropathological feature of progressive supranuclear palsy
Listen to the fascinating insights exploring the autoimmune side of progressive supranuclear palsy (PSP) following identification of cytotoxic T cells within the mid-brain of PSP post-mortem tissue. The pattern of T cells appears to follow both temporal progression of underlying PSP and may also relate to rate of disease progression. Professor Kovacs discusses potential autoimmune treatment in a neurodegenerative disorder, such as PSP, and others.
Check out the full article on the Brain website as part of the August 2025 issue: https://doi.org/10.1093/brain/awaf135
This episode was co-hosted, edited and produced by David Michael and Adam Handel, co-produced by Xin You Tai and Antonia Johnston, original music by Ammar Al-Chalabi.