Antibiotic CRI’s: Better Than Bolus? With Prof Steve Epstein. Bonus - Live At IVECCS
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Antibiotic CRI’s: Better Than Bolus? With Prof Steve Epstein. Bonus - Live At IVECCS
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About this listen
If you caught my conversation with Prof. Steve Epstein from IVECCS 2024, you already know this:
When it comes to septic patients, timing of antibiotics is everything. Ok, maybe not EVERYTHING, because in our follow-up discussion 1 year later at IVECCS 25, Prof Steve explored an idea that might just shift your ICU protocols: duration of administration matters.
That’s the idea behind the concept is prolonged infusion - giving time-dependent antibiotics over extended periods for more sustained bacterial kill time. (Spoiler alert: it works. BUT...with a few caveats.)
Jump in to this one for a straight-forward data backed action you can take with your critical patients that will save more lives.
Topics We Unpacked:
- Time-dependent vs. concentration-dependent antibiotics
- Prolonged infusion vs. continuous rate infusion (CRI)
- Human evidence: findings from the BLING III trial
- Applicability of human data to veterinary patients
- Dosing challenges and pharmacokinetics in septic animals
- Practical recommendations for veterinary ICU settings
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