Hugh of Singleton, fourth son of a minor knight, has been educated as a clerk, usually a prelude to taking holy orders. However, feeling no certain calling despite a lively faith, he turns to the profession of surgeon, training in Paris and then hanging out his sign in Oxford. A local lord asks him to track the killer of a young woman whose bones have been found in the castle cesspit. She is identified as the impetuous missing daughter of a local blacksmith, and her young man, whom she had provoked very publicly, is in due course arrested and sentenced at the Oxford assizes.

Ralph Delchard, a soldier who fought at the Battle of Hastings, and Gervase Bret, a talented lawyer, have been commissioned by William the Conqueror to look into irregularities brought to light during the compilation of the Domesday Book. A man’s body is found mutilated in Savernake Forest and the residents of Bedwyn sleep uneasy at night, fearing a monster stalking the town. When Ralph Delchard and Gervase Bret arrive, they discover that the locals are harbouring dark secrets and that the real killer may be a little closer to home....

Matthew Bartholomew, unorthodox but effective physician to Michaelhouse college in medieval Cambridge, is as worried as anyone about the pestilence that is ravaging Europe and seems to be approaching England. But he is distracted by the sudden and inexplicable death of the Master of Michaelhouse - a death the University authorities do not want investigated.

As a bard's daughter, Gwen has spent her life traveling from castle to castle and village to village with her family, following the music. In the winter of 1141, Gwen's family is contracted to provide the entertainment for the coming-of-age celebration of a lord's son. But before the celebration can begin, Gwen's father is found over the body of his friend, with a harp string as the murder weapon and blood on his hands. With the lord of the castle uninterested in finding the true killer, it is up to Gwen to clear her father's name before her father's music is silenced...forever.

Dorothea Brooke is an ardent idealist who represses her vivacity and intelligence for the cold, theological pedant Casaubon. One man understands her true nature: the artist Will Ladislaw. But how can love triumph against her sense of duty and Casaubon’s mean spirit? Meanwhile, in the little world of Middlemarch, the broader world is mirrored: the world of politics, social change, and reforms, as well as betrayal, greed, blackmail, ambition, and disappointment.