Showing results by publisher "----RM Alexander" in Genetics

If you could bring back one living being from the whole of the history of time, what would you choose? Comedian and former stem-cell biologist Helen Pilcher has thought about this problem - a lot. In Bring Back the King, Helen explains the cutting-edge science that makes the resurrection of extinct animals a very real possibility and highlights her choices from eras gone by, from the king of the dinosaurs, Tyrannosaurus rex, to the King of Rock 'n' Roll, Elvis Presley.

Cancer has always been with us. It killed our hominid ancestors, the mammals they evolved from and the dinosaurs that trampled the ground before that. Tumours grow in pets, livestock and wild animals. Even tiny jelly-like Hydra - creatures that are little more than a tube full of water - can get cancer. Paradoxically, many of us think of cancer as a contemporary killer, a disease of our own making caused by our modern lifestyles.

For decades after the structure of DNA was identified, scientists focused purely on genes, the regions of the genome that contain codes for the production of proteins. Other regions - 98 percent of the human genome - were dismissed as ‘junk’. But in recent years researchers have discovered that variations in this ‘junk’ DNA underlie many previously intractable diseases, and they can now generate new approaches to tackling them.

Few people know much about stem cell research beyond the ethical questions raised by using embryos. But in the last decade, stem cell research has made huge advances toward eliminating some of our most intractable diseases. Now this sweeping and accessible book introduces us to this cutting-edge science, which will revolutionize medicine and change the way we think about and treat disease.

In 2010, scientists led by J. Craig Venter became the first to successfully create "synthetic life" - putting humankind at the threshold of the most important and exciting phase of biological research, one that will enable us to actually write the genetic code for designing new species to help us adapt and evolve for long-term survival. The science of synthetic genomics will have a profound impact on human existence, including chemical and energy generation, health, clean water and food production, environmental control, and possibly even our evolution.

Genetic engineering, which refers to the direct manipulation of DNA, became a reality in the 1970s. In this audiobook, we take a look at how far the field has come, starting with a revolutionary gene-editing tool called CRISPR that’s taking the research world by storm. We then examine how CRISPR and other approaches are being investigated to treat disease, the fantastic-sounding research being done in synthetic biology, controversial efforts in modifying crops and saving species, as well as the numerous ethical issues raised in these areas.

At a conference in Hong Kong in November 2018, Dr. He Jiankui announced that he had created the first genetically modified babies - twin girls named Lulu and Nana - sending shockwaves around the world. A year later, a Chinese court sentenced Dr. He to three years in prison for "illegal medical practice". As scientists elsewhere start to catch up with China's vast genetic research program, gene editing is fueling an innovation economy that threatens to widen racial and economic inequality. Fundamental questions about science, health, and social justice are at stake.

Just 45 years ago, the age of gene modification was born. Researchers could create glow-in-the-dark mice, farmyard animals producing drugs in their milk, and vitamin-enhanced rice that could prevent half a million people going blind every year. But now GM is rapidly being supplanted by a new system called CRISPR or "gene editing". Using this approach, scientists can manipulate the genes of almost any organism with a degree of precision, ease and speed that we could only dream of ten years ago.

In recent years, genetic testing has become easily available to consumers across the globe, making it relatively simple to find out where your ancestors came from. But what do these test results actually tell us about ourselves? In Ancestors, Pierre Zalloua, a leading authority on population genetics, argues that these test results have led to a dangerous oversimplification of what one’s genetic heritage means. Genetic ancestry has become conflated with anthropological categories such as “origin,” “ethnicity,” and even “race” in spite of the complexities that underlie these concepts.

Each animal on the planet owes its existence to one very simple but crucial piece of evolutionary engineering: the egg. It's time to tell a new story of life on Earth.

A powerful treatise that demonstrates the existence of altruism in nature, with surprising implications for human society. Does altruism exist? Or is human nature entirely selfish? In this eloquent and accessible book, famed biologist David Sloan Wilson provides new answers to this age-old question based on the latest developments in evolutionary science.

Again and again, microbes have shaped our health, our genetics, our history, our culture, our politics, even our religion and ethics. This book reveals much that scientists and cultural historians have learned about the pervasive interconnections between infectious microbes and humans. It also considers what our ongoing fundamental relationship with infectious microbes might mean for the future of the human species.

A new gene editing technology, invented just seven years ago, has turned humanity into gods. Enabling us to manipulate the genes in virtually any organism with exquisite precision, CRISPR has given scientists a degree of control that was undreamt of even in science fiction. But CRISPR is just the latest, giant leap in a long journey to master genetics. The Genetic Age shows the astonishing, world-changing potential of the new genetics and the possible threats it poses, sifting between fantasy and the reality when it comes to both benefits and dangers.

In November 2018, the world was shocked to learn that two babies had been born in China with DNA edited while they were embryos - as dramatic a development in genetics as the cloning of Dolly the sheep was in 1996. In this book, Hank Greely, a leading authority on law and genetics, tells the fascinating story of this human experiment and its consequences. Greely explains what Chinese scientist He Jiankui did, how he did it, and how the public and other scientists learned about and reacted to this unprecedented genetic intervention.

While traditional drugs mostly help us manage the effects of disease, cell therapies promise genuine cures for a broad range of intractable ailments, from Alzheimer’s to heart damage to cancer. They could even reverse the effects of aging. For the first time in history, on an unprecedented scale, we possess the power to modify the biology that gives rise to disease, ultimately restoring individuals to a state of normalcy and reversing debilitating ailments. Former FDA Commissioner Scott Gottlieb traces the scientific achievements that propelled progress in cell therapies.

The language of genes has become common parlance. We know they make your eyes blue, your hair curly or your nose straight. The media tells us that our genes control the risk of cancer, heart disease, alcoholism or Alzheimer's. The cost of DNA sequencing has plummeted from billions of pounds to a few hundred, and gene-based advances in medicine hold huge promise. So we've all heard of genes, but how do they actually work?

Unravelling the Double Helix covers the most colourful period in the history of DNA, from the discovery of 'nuclein' in the late 1860s to the publication of Watson's The Double Helix in 1968. This is a saga packed with awful mistakes as well as brilliant science, with a wonderful cast of heroes and villains. Surprisingly, much of it is unfamiliar because the early history is largely neglected by books which focus on the episode of the double helix.

In an age of groundbreaking scientific discovery, RNA Vaccines: A New Frontier in Science takes listeners on an illuminating journey through one of the most transformative innovations in modern medicine. From the frontlines of the COVID-19 pandemic to the promise of personalized therapies, RNA vaccines have reshaped our understanding of immunology, biotechnology, and global health.

Orphan is about the struggle to save the lives of children who, because of an unlucky roll of the genetic dice, are born with any one of several thousand rare genetic disorders. Many are burdened with diseases that carry mysterious names, some of which you will hear about for the first time in this audiobook, along with compelling stories about the physicians, scientists, and parents who have taken them on.

Inevitably, life on Earth will come to an end, whether by climate disaster, cataclysmic war, or the death of the sun in a few billion years. To avoid extinction, we will have to find a new home planet, perhaps even a new solar system, to inhabit. In this provocative and fascinating book, Christopher Mason argues that we have a moral duty to do just that.