• Doctors' Notes: Dopamine
    Dec 9 2025

    Chris and Xand continue their conversation about dopamine with Masud Husain, Professor of Neurology & Cognitive Neuroscience at the University of Oxford. They explore how he first became interested in dopamine, what happens when dopamine systems become overactive, underactive, or disrupted, and whether we have any real control over our dopamine at all. Masud also shares the one thing he wishes everyone understood about dopamine.

    If you’d like to share your thoughts on this or any other topic covered on the podcast, you email us at whatsupdocs@bbc.co.uk or Whatsapp on 08000 665 123.

    Presenters: Drs Chris and Xand van Tulleken Guest: Professor Masud Husain Producer: Maia Miller-Lewis Executive Producer: Rami Tzabar Editor: Jo Rowntree Researcher: Grace Revill Tech Lead: Reuben Huxtable Social Media: Leon Gower Digital Lead: Richard Berry Composer: Phoebe McFarlane Sound Design: Melvin Rickarby

    At the BBC: Assistant Commissioner: Greg Smith Commissioning Editor: Rhian Roberts

    A Loftus Media production for BBC Radio 4.

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    22 mins
  • Can you be ‘addicted to dopamine’?
    Dec 9 2025

    Welcome to What’s Up Docs?, the podcast where doctors and identical twins Chris and Xand van Tulleken untangle the confusion around every aspect of our health and wellbeing.

    In this episode, they’re diving into dopamine – one of the most talked-about chemicals in modern wellness culture. But what is dopamine, really? What role does it play in pleasure, motivation, learning, and movement? And how accurate are ideas like “dopamine hits”, “dopamine detoxes”, or being “addicted to dopamine”?

    Chris and Xand speak to Masud Husain, Professor of Neurology & Cognitive Neuroscience at the University of Oxford, to cut through the myths and find out what dopamine does, what it doesn’t do, and why understanding it properly might change the way we think about our behaviour and our brains.

    If you want to get in touch, you can email us at whatsupdocs@bbc.co.uk or WhatsApp us on 08000 665 123.

    Presenters: Drs Chris and Xand van Tulleken Guest: Professor Masud Husain Producer: Maia Miller-Lewis Executive Producer: Rami Tzabar Editor: Jo Rowntree Researcher: Grace Revill Tech Lead: Reuben Huxtable Social Media: Leon Gower Digital Lead: Richard Berry Composer: Phoebe McFarlane Sound Design: Melvin Rickarby

    At the BBC: Assistant Commissioner: Greg Smith Commissioning Editor: Rhian Roberts

    A Loftus Media production for BBC Radio 4

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    29 mins
  • Doctors' Notes: Beliefs
    Dec 2 2025

    Chris and Xand continue their conversation about belief with Ryan McKay, Professor of Psychology at Royal Holloway, University of London.

    They want to know why some beliefs take hold so strongly, what’s happening in our brains when we hold on to them, and how trust, identity, and community shape what we believe. Beyond that, they’ll explore why health beliefs can be so difficult to shift, and whether it’s ever really possible to change someone’s mind. From the psychology of delusions to the spread of everyday health narratives, this episode dives deeper into the mechanics of belief.

    If you’d like to share your thoughts on this or any other topic covered on the podcast, you email us at whatsupdocs@bbc.co.uk or Whatsapp on 08000 665 123.

    Presenters: Drs Chris and Xand van Tulleken Guest: Professor Ryan McKay Producer: Maia Miller-Lewis Executive Producer: Rami Tzabar Editor: Jo Rowntree Researcher: Grace Revill Tech Lead: Reuben Huxtable Social Media: Leon Gower Digital Lead: Richard Berry Composer: Phoebe McFarlane Sound Design: Melvin Rickarby

    At the BBC: Assistant Commissioner: Greg Smith Commissioning Editor: Rhian Roberts

    A Loftus Media production for BBC Radio 4

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    20 mins
  • Does what we believe about our health affect it?
    Dec 2 2025

    Welcome to What’s Up Docs?, the podcast where doctors and identical twins Chris and Xand van Tulleken confront the confusion around every aspect of our health and wellbeing.

    In this episode, they’re asking why beliefs about our bodies are so powerful? We often think of belief as something soft – just ideas in our heads. But beliefs can shape how we experience pain, how we heal, and even how societies behave. In health, they can influence whether treatments work and how symptoms are felt.

    So what actually are beliefs? Why do we them, and how do they form? And can changing what we believe about our bodies actually change how we feel?

    To help answer these questions, Chris and Xand are joined by Ryan McKay, Professor of Psychology at Royal Holloway, University of London, and an expert on the psychology of belief.

    If you want to get in touch, you can email us at whatsupdocs@bbc.co.uk or WhatsApp us on 08000 665 123.

    Presenters: Drs Chris and Xand van Tulleken Guest: Professor Ryan McKay Producer: Maia Miller-Lewis Executive Producer: Rami Tzabar Editor: Jo Rowntree Researcher: Grace Revill Tech Lead: Reuben Huxtable Social Media: Leon Gower Digital Lead: Richard Berry Composer: Phoebe McFarlane Sound Design: Melvin Rickarby

    At the BBC: Assistant Commissioner: Greg Smith Commissioning Editor: Rhian Roberts

    A Loftus Media production for BBC Radio 4

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    29 mins
  • Doctors' Notes: Dry Skin
    Nov 25 2025

    Drs Chris and Xand continue their conversation about dry skin with Dr Tess McPherson, Associate Professor of Paediatric and Adolescent Dermatology at the University of Oxford.

    The docs want to know what eczema is, why it happens, whether it is worth eliminating triggers and whether topical steroids are an effective treatment. They also explore the stigma around skin conditions and what we can all do to address it, and hear Dr McPherson’s personal and clinical perspective on dry skin and skincare in general.

    If you’d like to share your thoughts on this or any other topic covered on the podcast, you email us at whatsupdocs@bbc.co.uk or Whatsapp on 08000 665 123.

    Presenters: Drs Chris and Xand van Tulleken Guest: Dr Tess McPherson Researcher: Mili Ostojic Producer: Faye Lyons White Assistant Producer: Maia Miller-Lewis Social Media Producer: Leon Gower Executive Producer: Rami Tzabar Editor:Jo Rowntree Tech Lead: Reuben Huxtable Digital Lead: Richard Berry Composer: Phoebe McFarlane Sound Design: Melvin Rickarby

    At the BBC: Assistant Commissioner: Greg Smith Commissioning Editor: Rhian Roberts

    A Loftus Media production for BBC Radio 4.

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    25 mins
  • How should you relieve dry skin?
    Nov 25 2025

    Welcome to What’s Up Docs?, the podcast where doctors and identical twins Chris and Xand van Tulleken cut through the confusion around every aspect of our health and wellbeing.

    In this episode, Chris and Xand dive into dry skin and how it can be relieved. Why does dry skin happen? How can your washing and cleansing routine affect your skin? Should you use moisturisers, and how do they work? Can you use too many products? They explore the biology of dry skin, whether it can be prevented, the trends surrounding the care of dry skin, and the science of moisturisers.

    Joining them to discuss this is Dr Tess McPherson, Associate Professor of Paediatric and Adolescent Dermatology at the University of Oxford and consultant dermatologist at Oxford University Hospitals.

    If you want to get in touch, you can email us at whatsupdocs@bbc.co.uk or WhatsApp us on 08000 665 123.

    Presenters: Drs Chris and Xand van Tulleken Guest: Dr Tess McPherson Researcher: Mili Ostojic Producer: Faye Lyons White Assistant Producer: Maia Miller-Lewis Social Media Producer: Leon Gower Executive Producer: Rami Tzabar Editor:Jo Rowntree Tech Lead: Reuben Huxtable Digital Lead: Richard Berry Composer: Phoebe McFarlane Sound Design: Melvin Rickarby

    At the BBC: Assistant Commissioner: Greg Smith Commissioning Editor: Rhian Roberts

    A Loftus Media production for BBC Radio 4

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    29 mins
  • Doctors' Notes: Hot and Cold Therapies
    Nov 18 2025

    Chris and Xand continue their conversation about body temperature with Dr Heather Massey, Associate Professor of extreme environments and physiology at the University of Portsmouth.

    Drs Chris and Xand van Tulleken want to know how cold water swimming and contrast therapy can challenge your body temperature and what the benefits might be. They also explore whether everyone should be challenging their body temperature, and whether there are alternatives to the extreme methods. They also hear Dr Massey’s personal and clinical perspective on cold water swimming.

    If you’d like to share your thoughts on this or any other topic covered on the podcast, you email us at whatsupdocs@bbc.co.uk or Whatsapp on 08000 665 123.

    Presenters: Drs Chris and Xand van Tulleken Guest: Dr Heather Massey Producer: Faye Lyons-White and Maia Miller-Lewis Executive Producer: Rami Tzabar Editor: Jo Rowntree Researcher: Mili Ostojic Tech Lead: Reuben Huxtable Social Media: Leon Gower Digital Lead: Richard Berry Composer: Phoebe McFarlane Sound Design: Melvin Rickarby

    At the BBC: Assistant Commissioner: Greg Smith Commissioning Editor: Rhian Roberts

    A Loftus Media production for BBC Radio 4.

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    27 mins
  • Do hot and cold therapies work?
    Nov 18 2025

    Welcome to What’s Up Docs?, the podcast where doctors and identical twins Chris and Xand van Tulleken cut through the confusion around every aspect of our health and wellbeing.

    In this episode, Chris and Xand dive into body temperature and how it can be challenged. How does the human body regulate its core and skin temperature? Can you change your body temperature from its average value? Should you challenge your body temperature by exposing yourself to hot environments? They explore the biology of body temperature, the impact of cold therapies and look at the claimed benefits of saunas.

    Joining them to discuss this is Dr Heather Massey, Associate Professor of extreme environments and physiology at the University of Portsmouth.

    If you want to get in touch, you can email us at whatsupdocs@bbc.co.uk or WhatsApp us on 08000 665 123.

    Presenters: Drs Chris and Xand van Tulleken Guest: Dr Heather Massey Researcher: Mili Ostojic Producers: Faye Lyons White and Maia Miller-Lewis Social Media Producer: Leon Gower Executive Producer: Rami Tzabar Editor: Jo Rowntree Tech Lead: Reuben Huxtable Digital Lead: Richard Berry Composer: Phoebe McFarlane Sound Design: Melvin Rickarby

    At the BBC: Assistant Commissioner: Greg Smith Commissioning Editor: Rhian Roberts

    A Loftus Media production for BBC Radio 4

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    29 mins