Listener feedback on the PROGRESS trial, the first Factor XI inhibitor improved, left bundle branch pacing, and statin discontinuation in older adults are the topics John Mandrola, MD, discusses in this week’s podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I Listener Feedback

• PROGRESS Trial https://www.nejm.org/doi/abs/10.1056/NEJMoa2607326

II FDA Approves Asundexian in Stroke

Will FDA-Approved Factor XIa Change Secondary Stroke Prevention? https://www.medscape.com/viewarticle/will-fda-approved-factor-xia-change-secondary-stroke-2026a100177u

• OCEANIC-STROKE Trial https://www.nejm.org/doi/10.1056/NEJMoa2513880
• Bleeding With Asundexian vs Placebo in Patients With Ischemic Stroke or High-Risk TIA https://pubmed.ncbi.nlm.nih.gov/42866879/
• OCEANIC-AF trial https://www.nejm.org/doi/full/10.1056/NEJMoa2407105

III Another Weak Pacing RCT – OptimPacing

The Best Pacing Strategy for AV Block: A Head vs Heart Analysis of The OptimPacing Trial https://www.medscape.com/viewarticle/best-pacing-strategy-av-block-head-vs-heart-analysis-2026a10016rn

• LEAP-Block Trial https://jamanetwork.com/journals/jama/fullarticle/2855975
• OptimPacing Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2612972

IV STREAM Trial

Statins Work in Older Adults, Statistics Be Damned: The STREAM Trial https://www.medscape.com/viewarticle/statins-work-older-adults-statistics-be-damned-stream-trial-2026a10016oo

• STREAM Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2606634
• STAREE Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2607314

The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington

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The moderate aortic stenosis TAVR trial, blinded withdrawal in the DECISION digoxin trial, CTO-PCI vs no CTO-PCI 10-year results, and the P4 trial are the topics John Mandrola, MD, discusses in this week’s podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I PROGRESS Trial

• PROGRESS Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2607326
• PROGRESS Trial Editorial https://www.nejm.org/doi/full/10.1056/NEJMe2613400
• Genereux Classification https://academic.oup.com/eurheartj/article/38/45/3351/4002776

II Withdrawing Digoxin in the DECISION trial

• DECISION Trial Substudy https://academic.oup.com/eurheartj/article/47/38/5545/8674856
• DECISION Trial - Main Trial https://www.nature.com/articles/s41591-026-04406-6
• Efficacy and Safety of Digitalis Glycosides in HF: Meta-analysis https://jamanetwork.com/journals/jama/fullarticle/2848972
• RADIANCE trial https://www.nejm.org/doi/full/10.1056/NEJM199307013290101
• PROVED trial https://www.jacc.org/doi/10.1016/0735-1097(93)90403-N

III DECISION CTO Trial at 10 Years

• DECISION-CTO Trial 10-Year Outcomes 10.1016/j.jacc.2026.10.068
• DECISION-CTO Main paper https://doi.org/10.1161/CIRCULATIONAHA.118.031313
• EURO-CTO trial https://eurointervention.pcronline.com/article/three-year-outcomes-of-eurocto-a-randomized-multicentre-trial-comparing-revascularization-and-optimal-medical-therapy-for-chronic-total-coronary-occlusions
• COMET-CTO trial https://pmc.ncbi.nlm.nih.gov/articles/PMC9868942/
• EXPLORE Trial https://www.ahajournals.org/doi/10.1161/JAHA.123.033556
• ORBITA-CTO trial https://www.jacc.org/doi/10.1016/j.jacc.2026.03.027

IV The P4 Trial

Coronary CT Angiography Cuts Procedural Time Relative to IVUS-Guided PCI https://www.medscape.com/viewarticle/coronary-ct-angiography-cuts-procedural-time-relative-ivus-2026a1001684

• P4 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2610771

The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington

Questions or feedback, please contact news@medscape.net

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The ASPIRED syncope RCT, two studies in coronary artery calcium scoring, and the LEAP-Block trial of CSP vs RV pacing are the topics John Mandrola, MD, discusses in this week’s podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I Syncope

• ASPIRED Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2605812
• REMOSYNCED Trial https://clinicaltrials.gov/study/NCT05066347

II TWO CAC Studies

• Atherosclerosis in Young Adults and Risk of Mortality Over 30 Years https://jamanetwork.com/journals/jamacardiology/fullarticle/2855732
• Predictive Utility of CAC Score Added to PREVENT Score https://jamanetwork.com/journals/jama/fullarticle/2853347

III Conduction System Pacing vs Standard RV Pacing for AV block

• LEAP-Block Trial https://jamanetwork.com/journals/jama/fullarticle/2855975
• Meta-analysis: CSP vs RV Pacing in Preserved or Mildly Reduced EF https://doi.org/10.1016/j.cjca.2026.04.009

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The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington

Questions or feedback, please contact news@medscape.net

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