Episodes

  • Gut-Brain Axis: The Hidden Root of Anxiety, Brain Fog and Fatigue

    Gut-Brain Axis: The Hidden Root of Anxiety, Brain Fog and Fatigue
    Oct 30 2025
    We've been taught to think of the brain as the command center of our mental health - sending orders, dictating moods, and controlling focus. What if the brain is just half the equation? What if the real commander is your gut? The brain and gut are far more connected than most people realize. Every bite you take sparks a chemical conversation between them; one that can calm your mind or trigger anxiety, brain fog, and low motivation. For years, we've tried to fix those symptoms with pills, hoping chemistry alone could restore balance. But the truth is, no drug can outsmart an inflamed gut. The science now shows that your mental health is not just in your head. It's shaped by the bacteria in your intestines, the food on your plate, and the way you manage stress, sleep, and community. When the gut falters, the brain follows, but when you repair the gut, you can literally rewire your mood and energy at the genetic level. How do we fix the gut, and how does that impact the brain? In this episode of The Trusted Pharmacist, I break down the five-step process to restore a healthy gut-brain connection. I talk about how to remove irritants, re-inoculate with key psychobiotics, repair the gut lining, and rebalance lifestyle habits that calm the nervous system. Things You'll Learn In This Episode The gut-brain highway Your gut talks to your brain every minute of the day. Could the anxiety and brain fog you feel be signals of distress from your microbiome? Inflammation: the hidden saboteur When gut bacteria leak toxins into the bloodstream, they inflame the brain's immune system. How do you quell this invisible fire? The nutrient-absorption trap Even the best diet or supplements can fail if your stomach acid and bile aren't working. Are you actually absorbing what your brain needs to thrive? Five steps to rebuild the connection From removing irritants to restoring vagal tone, what evidence-based strategies can transform mental clarity and mood from the inside out? References PMC 12436269 (2025) – Microbiota–Gut–Brain Axis in Neurodegenerative Diseases. Microbiota–gut–brain axis in neurodegenerative diseases: molecular mechanisms and therapeutic targets ScienceDirect (2025) – New Insights in the Gut–Brain Axis: Bioelectrical Microbiome. https://www.sciencedirect.com/science/article/pii/S2214799325000839 Frontiers in Aging Neuroscience (2025) – Microbiota–Gut–Brain Axis in Mental and Neurodegenerative Disorders. Frontiers | The microbiota–gut–brain axis in mental and neurodegenerative disorders: opportunities for prevention and intervention PMC 12405295 (2025) – Neuroplasticity and the Microbiome. Neuroplasticity and the microbiome: how microorganisms influence brain change PMC 11846350 (2025) – Plasma Short‑Chain Fatty Acids and Cognition. Association between plasma short-chain fatty acids and inflammation in human immunodeficiency virus-associated neurocognitive disorder: a pilot study PMC 11959655 (2025) – Bile Acid Signal Transduction and Neurological Function. Dysregulation of bile acid signal transduction causes neurological dysfunction in cirrhosis rats PMC 12071821 (2025) – Mechanisms of Bile Acids and Receptors in Brain Inflammation. Research Progress on the Mechanism of Bile Acids and Their Receptors in Depression PMC 10051340 (2023) – Tryptophan and Kynurenine Pathway in Microbiota–Brain Interactions. The Tryptophan and Kynurenine Pathway Involved in the Development of Immune-Related Diseases Nature (2025) – The Stomach's Turn: Elucidating the Gut–Brain Axis. https://www.nature.com/articles/s44220‑025‑00489‑1 10. Gut (2025) – Fasting and Cognition Via Microbiota Resets. https://gut.bmj.com/content/74/11/1828 11. Nature (2025) – Probiotics Reduce Negative Mood Over Time. https://www.nature.com/articles/s44184‑025‑00123‑z About Your Host Steve Hoffart is an award-winning pharmacist, entrepreneur, speaker, and podcaster. As the visionary founder of Magnolia Pharmacy, Steve saw a need for a more personal pharmacy that could make a bigger impact. Today, Steve and his team of experts deliver on that promise, working with patients and their physicians to solve medication problems and offer personalized solutions to achieve better health and wellness. As host of The Trusted Pharmacist podcast and through his combined reach of over 250,000 on social media, Steve shares actionable advice on nutrition, supplements, and wellness strategies while advocating for meaningful change in healthcare. Follow the Trusted Pharmacist on Apple Podcasts, Spotify, or your favorite podcast app so you get the latest episodes! If the show has been helpful, leave us a review on Apple Podcasts —or simply tell ...
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    21 mins
  • Food as Medicine: The Diet That Outperforms Any Drug w/ Dr. Barry Sears

    Food as Medicine: The Diet That Outperforms Any Drug w/ Dr. Barry Sears
    Oct 23 2025
    Most people think of food as fuel: calories in, calories out. But that’s not even close to the truth. Food is information. It’s the language your body speaks in to turn genes on or off, to heal or to harm. Every bite you take is either moving you closer to inflammation and disease… or reprogramming your body to perform like a Ferrari instead of an old pickup truck. That’s not an exaggeration. It’s the foundation of Dr. Barry Sears’ life’s work. Long before “biohacking” was a buzzword, he was using food as a drug, manipulating macronutrients and omega-3 fatty acids to literally engineer metabolism at the genetic level. What if you could treat your metabolism the same way an engineer tunes a high-performance machine, not by adding more fuel, but by optimizing the signals that keep it running? That’s the promise behind using food as a drug. Because inflammation isn’t random, it’s a software glitch. When the signals between your cells and hormones get scrambled by poor nutrition, stress, or the wrong kinds of fat, your metabolism breaks down. You gain weight, lose focus, and speed up the aging process without realizing it. But the same mechanism that breaks you down can also rebuild you. The right balance of protein, carbohydrates, and omega-3s doesn’t just prevent disease, it reprograms how your genes behave. You can turn off chronic inflammation, sharpen mental clarity, improve insulin sensitivity, and even reverse conditions like type 2 diabetes with precision nutrition. How do we eat to reprogram our bodies? Why does the balance between omega-6 and omega-3 fats determine everything? In this conversation, the leading biochemist, Metabolic Engineering pioneer, and creator of the Zone Diet shares how food can do what a pill can’t, and how to lower inflammation, reverse diabetes, and improve performance at every age. Things You’ll Learn In This Episode -Food as genetic code What if food isn’t fuel but software? How can the right mix of protein, carbs, and omega-3s reprogram 30 trillion cells for peak performance? -The real cause of aging and disease Most people think it’s genetics, but what if it’s unresolved inflammation below the pain threshold, silently damaging your cells every day? -The omega-3 to omega-6 equation Japanese longevity isn’t luck. What ratio of fats keeps inflammation in check, and why are most Americans twenty times out of balance? -Why “balance” beats every fad diet From keto to fasting, extreme diets miss the point. What happens when you bring your metabolism back to its therapeutic zone instead? P.S. Are you looking for a high-quality Omega supplement? Buy our Ultra Omega Max here: https://magnoliapharmacy.com/products/ultra-omega-max. Guest Bio Dr. Barry Sears is an author, leading biochemist, and creator of the Zone diet. He is considered the founder of Metabolic Engineering based on his ground-breaking research on the dietary manipulation of the hormones that control the initiation and resolution of inflammation. Dr. Barry Sears' groundbreaking research on diet, hormones, and inflammation has sold millions of books worldwide. As the founder of the Inflammation Research Foundation, he has dedicated his career to showing how food acts as medicine to treat chronic disease and extend health span. To learn more, go to https://zoneliving.com/ and https://drbarrysears.com/. About Your Host Steve Hoffart is an award-winning pharmacist, entrepreneur, speaker, and podcaster. As the visionary founder of Magnolia Pharmacy, Steve saw a need for a more personal pharmacy that could make a bigger impact. Today, Steve and his team of experts deliver on that promise, working with patients and their physicians to solve medication problems and offer personalized solutions to achieve better health and wellness. As host of The Trusted Pharmacist podcast and through his combined reach of over 250,000 on social media, Steve shares actionable advice on nutrition, supplements, and wellness strategies while advocating for meaningful change in healthcare. Follow the Trusted Pharmacist on Apple Podcasts, Spotify, or your favorite podcast app so you get the latest episodes! If the show has been helpful, leave us a review on Apple Podcasts —or simply tell a friend about the show. Each time you share the show, you are potentially changing someone’s life!
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    47 mins
  • Hormones Aren't Just Reproductive, They Are Your Body's Wifi w/ Dr. Lindsey Berkson

    Hormones Aren't Just Reproductive, They Are Your Body's Wifi w/ Dr. Lindsey Berkson
    Oct 16 2025
    When most people think about hormones, they think sex, reproduction, or maybe aging. But that's far too narrow. Hormones are the Wi-Fi of your body. They are the invisible signals that keep your brain sharp, your gut sealed, your heart protected, and your immune system resilient. When that Wi-Fi weakens, nothing else runs the way it should. That idea comes straight from Dr. Devaki Lindsey Berkson, a trailblazer in functional medicine who has spent decades translating complex hormone science into clear, practical insights. And it matters, because the story most of us have been told about hormones is flat-out wrong. Estrogen has been vilified, progesterone dismissed, and women told they've "missed their window" for therapy. But that narrative isn't based on science; it's fueled by fear, bias, and outdated education. The research actually shows that natural hormones protect against disease, support healing, and can transform quality of life well into a woman's seventies, eighties, and nineties. In this episode, we cut through the myths and confusion about hormones. We unpack why synthetic progestins are so harmful, how emotional arguments have overshadowed evidence, and what the science really tells us about hormone therapy at every stage of life. Things You'll Learn In This Episode -Hormones as the body's Wi-FiHormones don't just regulate reproduction; they run the signals for your brain, gut, immunity, and healing. What happens when that Wi-Fi goes offline? -The progesterone vs. progestin problemMost women are prescribed synthetic progestins, not real progesterone. What harm do these impostors cause, and why aren't patients told the difference? -Emotion vs. science in hormone debatesMuch of the fear surrounding hormones is emotional, rather than evidence-based. How does science actually stack up against the myths? -The myth of the "estrogen window"Is it really too late to start hormones after your 60s or 70s, or can thoughtful replacement transform health at any age? PS. If you enjoy the show, remember to leave a review on your favorite podcast app! Reviews help the podcast reach a wider audience and help more people. Guest Bio Dr. Devaki Lindsey Berkson, MA, DC, CNS, DACBN, ACN, is known as a thought leader in functional medicine. With an emphasis on hormones, nutrition, and digestion, Dr. Berkson has been a distinguished scholar at an estrogen think tank from Tulane University. She is a best-selling author of 22 books, such as the first gut/body/mind/nutrition book (Healthy Digestion the Natural Way, Wiley, 1998) and the breakthrough book on endocrine-disrupting compounds (Hormone Deception, McGraw-Hill, 2000). Berkson has taught relicensing seminars to professionals (MDs, pharmacists, chiropractors, NDs, acupuncturists, nutritionists) as well as symposiums for the lay public for almost four decades. Dr. Devaki Lindsey Berkson specializes in complex cases, high-risk hormonal patients, and severe gastroenterologic cases, trying to avoid surgery. Berkson knows how to connect the dots of cutting-edge research and has a large background of personal clinical experience with success in difficult cases to pull from. Dr. Berkson is an agile thinker with lots of clinical, academic, and scientific background and has been in practice as a nutritionist since the mid-1970s and as an integrative nutritional, gastrointestinal, and endocrine specialist since the early 1980s. Berkson consults all over the world. She works remotely as a consultant and can also work with your own doctors and become part of your personalized healthcare team. Visit https://drlindseyberkson.com/ to learn more, or subscribe to her Substack https://drlindseyberkson.substack.com/. About Your Host Steve Hoffart is an award-winning pharmacist, entrepreneur, speaker, and podcaster. As the visionary founder of Magnolia Pharmacy, Steve saw a need for a more personal pharmacy that could make a bigger impact. Today, Steve and his team of experts deliver on that promise, working with patients and their physicians to solve medication problems and offer personalized solutions to achieve better health and wellness. As host of The Trusted Pharmacist podcast and through his combined reach of over 250,000 on social media, Steve shares actionable advice on nutrition, supplements, and wellness strategies while advocating for meaningful change in healthcare. Follow the Trusted Pharmacist on Apple Podcasts, Spotify, or your favorite podcast app so you get the latest episodes! If the show has been helpful, leave us a review on Apple Podcasts —or simply tell a friend about the show. Each time you share the show, you are potentially changing someone's life!
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    51 mins
  • HRT, Birth Control, and Postpartum Hormones (What No One Tells You) w/ Elise Clark

    HRT, Birth Control, and Postpartum Hormones (What No One Tells You) w/ Elise Clark
    Oct 9 2025
    Hormones are at the center of women's health. Unfortunately, the stories we've been told (and the treatment that's provided) about are riddled with myths. Women believe that hormone replacement therapy is dangerous. They're handed birth control pills for years without being told what it might mean for their long-term health. Perimenopausal women are told they can only get hormone replacement when they are in menopause. New mothers are left believing there's little they can do about the hormonal crash that comes after pregnancy. The truth is far more nuanced. Hormones aren't villains to fear or band-aids to hand out without thought. That's where Elise Clark comes in. A nurse practitioner with deep experience in endocrinology, women's health, and functional medicine, she's made it her mission to dismantle these misconceptions and give women the clarity they deserve. Hormones are powerful tools that, when understood and used correctly, can protect long-term health and restore quality of life. Yet too often, women are left in the dark, navigating misinformation and missing out on solutions that could change everything. What are the biggest misconceptions about hormones? How do we tackle the hormone-related health challenges women face? In this episode, we dig into the most common hormone myths, from the breast cancer stigma around HRT, to the hidden downsides of birth control to postpartum hormone therapy. Things You'll Learn In This Episode -Hormones and cancer: myth vs. reality The data is clear: bioidentical hormones don't cause cancer; in fact, outcomes are often better. So why are women still told the opposite? -Birth control's hidden costs Beyond pregnancy prevention, long-term use can disrupt metabolic health, mask PCOS, and raise inflammation. What are the overlooked tradeoffs no one explains? -The overlooked phase: perimenopause Hot flashes, heavy periods, mood swings, these aren't just "part of life." How can progesterone make the transition smoother? -Postpartum recovery and progesterone From anxiety to sleep struggles, women are often given expensive infusions or antidepressants. Could a simple, affordable hormone be the safer solution? PS. If you enjoy the show, remember to leave a review on your favorite podcast app! Reviews help the podcast reach a wider audience and help more people. Guest Bio Elise Clark is a nurse practitioner, functional medicine expert, and health optimization expert. She has been in the nursing field for over 15 years, with the majority of that being as a nurse practitioner. She found her way into functional medicine after gaining experience in family practice and endocrinology. Elise realized there was more she could be doing for patients than what the traditional model offered, and she wanted to truly help people. She has been in the functional space for almost 10 years and has extensive experience with hormones, thyroid issues, female issues, gut health, nutrient deficiencies, and overall health optimization. Most recently, Elise co-founded a joint practice, Evergreen Functional Collective, to help expand patient access to functional care. To learn more, go to https://www.eliseclarkhealth.com/ and https://evergreenfunctional.com/. Follow @eliseclarkfnp on Instagram. About Your Host Steve Hoffart is an award-winning pharmacist, entrepreneur, speaker, and podcaster. As the visionary founder of Magnolia Pharmacy, Steve saw a need for a more personal pharmacy that could make a bigger impact. Today, Steve and his team of experts deliver on that promise, working with patients and their physicians to solve medication problems and offer personalized solutions to achieve better health and wellness. As host of The Trusted Pharmacist podcast and through his combined reach of over 250,000 on social media, Steve shares actionable advice on nutrition, supplements, and wellness strategies while advocating for meaningful change in healthcare. Follow the Trusted Pharmacist on Apple Podcasts, Spotify, or your favorite podcast app so you get the latest episodes! If the show has been helpful, leave us a review on Apple Podcasts —or simply tell a friend about the show. Each time you share the show, you are potentially changing someone's life!
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    30 mins
  • Why Your Vaginal Microbiome Is Just as Important as Your Gut

    Why Your Vaginal Microbiome Is Just as Important as Your Gut
    Oct 2 2025

    Most of us know the gut microbiome matters, but hardly anyone talks about the vaginal microbiome. Yet this tiny community of bacteria plays an outsized role in women's health. When it's in balance, you don't notice it. But when it's not, it can quietly set the stage for a long list of problems: recurring UTIs, yeast infections, BV, dryness, painful intimacy, even infertility and pregnancy complications.

    What's surprising is how often these issues get treated as separate problems when, in reality, the common thread is usually the same: an unhealthy or depleted microbiome. cause of stress, the microbiome weakens, and all those symptoms start to appear.

    The hopeful news is that balance can be restored. From vaginal probiotics and targeted strains to supplements, science now shows there are practical, effective ways to strengthen this first line of defense. And when you do, the ripple effect often improves far more than just vaginal health; it changes overall well-being.

    In this episode of The Trusted Pharmacist, I share how to finally break the cycle of antibiotics and recurring infections, and what it really takes to build lasting vaginal microbiome protection.

    Things You'll Learn In This Episode

    -Why diversity isn't always better

    Unlike the gut, the vaginal microbiome thrives on just a few defenders. What happens when too many different strains compete for space?

    -The hidden role of estrogen

    Estrogen protects your vaginal health. Could falling levels explain the sudden rise in UTIs, dryness, and discomfort during menopause?

    -Oral vs. vaginal probiotics

    Most people take probiotics orally, but evidence shows vaginal use resets the balance far faster. Which approach works best, and when should you use both?

    -How to stop the UTI spiral

    If you've been on antibiotics over and over again, you know the relief never lasts. What simple shifts and natural supports can actually stop infections from coming back?

    P.S. Are you looking for a vaginal probiotic tailored to your unique needs? Explore our Women's Restorative Probiotic and find the best solution for you:
    https://magnoliapharmacy.com/products/natures-womens-restorative-probiotic



    About Your Host

    Steve Hoffart is an award-winning pharmacist, entrepreneur, speaker and podcaster. As the visionary founder of Magnolia Pharmacy, Steve saw a need for a more personal pharmacy that could make a bigger impact. Today Steve and his team of experts deliver on that promise, working with patients and their physicians to solve medication problems and offer personalized solutions to achieve better health and wellness. As host of The Trusted Pharmacist podcast and through his combined reach of over 250,000 on social media, Steve shares actionable advice on nutrition, supplements, and wellness strategies while advocating for meaningful change in healthcare.



    Follow the Trusted Pharmacist on Apple Podcasts, Spotify, or your favorite podcast app so you get the latest episodes! If the show has been helpful, leave us a review on Apple Podcasts —or simply tell a friend about the show. Each time you share the show, you are potentially changing someone's life!
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    27 mins
  • High Cholesterol? Here’s What’s Really Going On w/ Dr. Yousef Elyaman

    High Cholesterol? Here’s What’s Really Going On w/ Dr. Yousef Elyaman
    Sep 25 2025
    For decades, cholesterol has been painted as the villain of heart disease. Doctors point to your LDL number, prescribe a statin, and send you home believing the problem is solved. It’s a clean, simple story, LDL is bad, HDL is good, but it’s also dangerously incomplete. Because here’s the reality: half of all fatal heart attacks happen in people with normal cholesterol levels. Which means the very test we’ve built our prevention strategy around is missing the mark. Lowering LDL might put out the smoke, but it doesn’t stop the fire. That’s where Dr. Yousef Elyaman comes in. A physician with nearly two decades of experience in cardiometabolic health and functional medicine, he’s seen firsthand how cholesterol misleads both patients and doctors. So what’s fueling the fire? Often it’s not cholesterol itself, but the hidden drivers behind it: chronic inflammation, insulin resistance, oxidative stress, and even genetics that shape how particles behave in the blood. Cholesterol is just the alarm bell, a signal that something deeper is burning. That’s why we need to reframe how we see cholesterol. Not as the cause, but as a clue. In this episode, we unpack the overlooked markers that reveal the real risk, and when statins may help in some cases but completely miss the point in others. Things You’ll Learn In This Episode -The hidden fires behind high cholesterol Cholesterol isn’t the cause; it’s the smoke. How do inflammation, insulin resistance, and oxidative stress fuel the real fire of heart disease? -The triglyceride trap Most labs say 150 is “normal,” but the true target is under 80. What does that number expose about your metabolic health and fatty liver risk? -The panels that reveal the truth Standard cholesterol tests miss the real danger. Which simple, affordable labs give you a clear picture of heart risk most doctors overlook? -Statins: help or harm? They lower cholesterol, but also deplete key nutrients, and don’t work for everyone. When are statins lifesaving, and when are they just masking the real issue? PS. If you enjoy the show, remember to leave a review on your favorite podcast app! Reviews help the podcast reach a wider audience and help more people. Guest Bio Dr. Yousef Elyaman is a highly accomplished and credentialed physician with an impressive academic background, including board certification in internal medicine and a cross-specialization in pediatrics. Additionally, he holds board certification in integrative medicine from the American Board of Physician Specialties. Moreover, Dr. Elyaman is one of the first graduates of The Institute for Functional Medicine, where he earned his certification in functional medicine. His expertise also extends to psychological trauma, and he holds certification from Spirit2Spirit Healing. As the founder and medical director of Absolute Health, located in Ocala, Florida, Dr. Elyaman has implemented a successful functional medicine approach to insurance-based primary care with a team that includes doctors, nurse practitioners, physician assistants, and lifestyle educators. He also serves as Integrative & Functional Medicine Director of The Guest House, an esteemed trauma and substance abuse center in Ocala, Florida. These accomplishments make Dr. Elyaman one of the most experienced voices in primary care functional and integrative medicine today; his knowledge is sought out for its ability to combine cutting-edge research with evidence-backed clinical applications that can be used effectively in real-world patient care scenarios. Follow @drelyaman and subscribe to his YouTube channel. About Your Host Steve Hoffart is an award-winning pharmacist, entrepreneur, speaker, and podcaster. As the visionary founder of Magnolia Pharmacy, Steve saw a need for a more personal pharmacy that could make a bigger impact. Today, Steve and his team of experts deliver on that promise, working closely with patients and their physicians to address medication issues and provide personalized solutions that lead to improved health and wellness. As host of The Trusted Pharmacist podcast and through his combined reach of over 250,000 on social media, Steve shares actionable advice on nutrition, supplements, and wellness strategies while advocating for meaningful change in healthcare. Follow the Trusted Pharmacist on Apple Podcasts, Spotify, or your favorite podcast app so you get the latest episodes! If the show has been helpful, leave us a review on Apple Podcasts —or simply tell a friend about the show. Each time you share the show, you are potentially changing someone’s life!
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    51 mins
  • Why One-Size-Fits-All Medicine Fails Fibromyalgia and Chronic Fatigue

    Why One-Size-Fits-All Medicine Fails Fibromyalgia and Chronic Fatigue
    Sep 18 2025

    When patients show up with chronic fatigue, fibromyalgia, or long COVID, the heartbreaking truth is that many doctors don't want to deal with them.

    These are the cases most physicians quietly dread, the ones that don't fit into a clean diagnosis or respond to a simple prescription. Too often, patients are told their labs are "normal," their symptoms are "just stress," or worse, that it's all in their head.

    But the reality is very different. These are not vague or imaginary conditions. They're the result of the body being assaulted on multiple fronts: hidden infections, mold exposure, gut breakdown, mitochondrial dysfunction, hormone disruption, chronic inflammation, and relentless stress.

    When the system is overwhelmed from many angles, no single pill or protocol will ever be enough. Healing requires a multi-layered approach, one that methodically unravels each insult, quiets the chaos, and restores balance across every system.

    What are the key differences between chronic fatigue and fibromyalgia? How do you finally start feeling better?

    In this episode of The Trusted Pharmacist, I lay out exactly why these conditions confound the traditional medical model and what science now reveals about their true root causes. I also share how patients can take practical steps to begin healing, often with tools their doctors have never even considered.

    Things You'll Learn In This Episode

    -Why single-diagnosis medicine fails

    Chronic fatigue, fibromyalgia, and long COVID are layered conditions, not one-off problems. What happens when we stop chasing a single cause and start treating the whole picture?

    -The hidden drivers of fatigue and pain

    Infections, mold, gut imbalances, hormone disruption, and toxins quietly fuel these syndromes. Could the key to recovery be uncovering what mainstream medicine ignores?

    -Lifestyle levers that matter more than you think

    Restorative sleep, pacing movement, trauma healing, and toxin testing all influence recovery. Why do these "non-medical" choices often make or break progress?

    -Emerging interventions on the frontier of care

    From methylene blue to therapeutic plasma exchange, new tools are reshaping outcomes. Could these cutting-edge options offer relief where everything else has failed?

    PS. If you enjoy the show, remember to leave a review on your favorite podcast app! Reviews help the podcast reach a wider audience and help more people.





    About Your Host

    Steve Hoffart is an award-winning pharmacist, entrepreneur, speaker and podcaster. As the visionary founder of Magnolia Pharmacy, Steve saw a need for a more personal pharmacy that could make a bigger impact. Today Steve and his team of experts deliver on that promise, working with patients and their physicians to solve medication problems and offer personalized solutions to achieve better health and wellness. As host of The Trusted Pharmacist podcast and through his combined reach of over 250,000 on social media, Steve shares actionable advice on nutrition, supplements, and wellness strategies while advocating for meaningful change in healthcare.

    Follow the Trusted Pharmacist on Apple Podcasts, Spotify, or your favorite podcast app so you get the latest episodes! If the show has been helpful, leave us a review on Apple Podcasts —or simply tell a friend about the show. Each time you share the show, you are potentially changing someone's life!
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    26 mins
  • The Hormone They Got Wrong: Progesterone's Real Story

    The Hormone They Got Wrong: Progesterone's Real Story
    Sep 11 2025

    When women struggle with hormone problems, PMS, irregular cycles, weight gain, insomnia, mood swings, or menopause symptoms, the blame almost always falls on estrogen. But here's the surprising truth: it's usually not estrogen at all. It's progesterone.

    For decades, progesterone has been treated as little more than a "pregnancy hormone." But in reality, it's one of the most misunderstood and underappreciated hormones in the body. Beyond fertility, progesterone calms the brain, balances mood, protects bones, supports gut and bladder health, and even helps reduce breast cancer risk.

    The problem is that most doctors misdiagnose estrogen "dominance" when the real issue is low progesterone.

    And even worse, the number-one thing that wrecks progesterone isn't aging, it's stress. Chronic cortisol production steals away its building blocks and shuts down its receptors, making your body resistant to the very hormone it needs most.

    In this episode of The Trusted Pharmacist, I break down why progesterone, not estrogen, is the missing piece in so many women's health struggles, how stress quietly sabotages your hormone balance, and why replacing progesterone properly is one of the most powerful (and overlooked) tools in restoring health.

    Things You'll Learn In This Episode

    -Progesterone: the bigger story
    Progesterone isn't just about reproduction; it's neuroactive, bone-protective, mood-balancing, and even cancer-protective. Why has medicine overlooked its full impact for so long?

    -Estrogen myths, progesterone truths
    What's often labeled as "estrogen dominance" is usually a progesterone deficiency in disguise. How does reframing the problem change the way we fix hormone imbalances?

    -Stress vs. aging: the real progesterone killer
    Yes, progesterone naturally declines with age, but high cortisol depletes it faster and blocks it from working. Could stress be more damaging to your hormones than menopause itself?

    -Smart replacement, not guesswork
    From capsules to creams to compounded options, how you dose and deliver progesterone changes everything. What's the safest and most effective way to restore balance without overdosing?

    PS. If you enjoy the show, remember to leave a review on your favorite podcast app! Reviews help the podcast reach a wider audience and help more people.

    About Your Host

    Steve Hoffart is an award-winning pharmacist, entrepreneur, speaker, and podcaster. As the visionary founder of Magnolia Pharmacy, Steve saw a need for a more personal pharmacy that could make a bigger impact. Today, Steve and his team of experts deliver on that promise, working with patients and their physicians to solve medication problems and offer personalized solutions to achieve better health and wellness. As host of The Trusted Pharmacist podcast and through his combined reach of over 250,000 on social media, Steve shares actionable advice on nutrition, supplements, and wellness strategies while advocating for meaningful change in healthcare.

    Follow the Trusted Pharmacist on Apple Podcasts, Spotify, or your favorite podcast app so you get the latest episodes! If the show has been helpful, leave us a review on Apple Podcasts —or simply tell a friend about the show. Each time you share the show, you are potentially changing someone's life!
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    25 mins