The GP Show cover art

The GP Show

The GP Show

By: Dr Sam Manger
Listen for free

Join GP Dr Sam Manger and special guests from around the World discussing the latest in evidence-based medicine and more. This podcast is designed-with-love for medical doctors, scientists, researchers, allied health, nurses, students and anybody else interested in health, science and medicine.Dr Sam Manger Hygiene & Healthy Living Physical Illness & Disease
Episodes
  • #223 Premenstrual Dysphoric Disorder (PMDD) with Professor Jayashri Kulkarni

    #223 Premenstrual Dysphoric Disorder (PMDD) with Professor Jayashri Kulkarni
    Jul 27 2026
    Professor Jayashri Kulkarni is one of Australia's leading psychiatrists and researchers specialising in women's mental health. She is the Director of the HER Centre Australia (Health, Education and Research for Women's Mental Health) and Professor of Psychiatry at Monash University. Professor Kulkarni's work focuses on mood disorders across the female lifespan, with particular attention to the neurochemical effects of reproductive hormones on brain function, including perimenopausal depression and premenstrual dysphoric disorder. She is the developer of the Meno-D rating scale and has been a leading voice for over four decades in the recognition and treatment of hormone-related mental illness in women. This is a supplementary episode to the GP Show's earlier conversation with Professor Kulkarni on perimenopausal mental health, recorded in the same sitting. In it, Dr. Ashlea Broomfield and Professor Kulkarni discuss what distinguishes PMDD from common premenstrual symptoms; the emerging evidence on trauma and gene expression as a mechanism for PMDD onset; why current guidelines default to SSRIs rather than hormonal treatment and the limitations of that approach; practical hormonal treatment options for women with and without contraceptive needs; and the role of trauma therapy alongside hormonal management. Professor Kulkarni argues that PMDD is a brain condition, not an end-organ condition, and that treatment should reflect that. RESOURCES "How to Treat PMDD" — Professor Jayashri Kulkarni, Australian Doctor. Read here UK Guidelines: The Green-top Guideline 48 — Management of Premenstrual Syndrome Green LJ, O'Brien PMS, Panay N, Craig M on behalf of the Royal College of Obstetricians andGynaecologists. Management of premenstrual syndrome. BJOG 2017 ; 124:e73–e105 HER Centre Australia — monash.edu/medicine/her-centre Perimenopausal Mental Health episode — The GP Show with Professor Jayashri Kulkarni Fast Facts in Sexual and Reproductive Health with Dr. Sara Whitburn — The GP Show ... If you find this podcast valuable, please help by rating the podcast 5 stars and leaving a review in your podcast app. If you would like to request a topic, please contact us via contact@thegpshow.com Thank you for listening and your support. ... Study and learn lifestyle medicine: Interested in whole of person clinical practice, research and careers that address the lifestyle and social determinants of illness and wellbeing, using lifestyle approaches, behaviour change, health coaching and implementation science? Check out the JCU College of Medicine postgraduate degrees: Graduate Certificate, Graduate Diploma, and Master in lifestyle medicine. Dr Sam Manger on YouTube: Using lifestyle as medicine: A new era in chronic disease remission and YouTube: Careers in lifestyle medicine The 3 week online microcredential in Lifestyle Medicine and Mental Health: Life and Mind available here.
    Show More Show Less
    31 mins
  • #222 Perimenopausal Mental Health with Professor Jayashri Kulkarni

    #222 Perimenopausal Mental Health with Professor Jayashri Kulkarni
    Jul 7 2026
    Professor Jayashri Kulkarni is one of Australia's leading psychiatrists and researchers specialising in women's mental health. She is the Director of the HER Centre Australia (Health, Education and Research for Women's Mental Health) and Professor of Psychiatry at Monash University. Professor Kulkarni's work focuses on mood disorders across the female lifespan, with particular attention to the neurochemical effects of reproductive hormones on brain function, including perimenopausal depression and premenstrual dysphoric disorder. She is the developer of the Meno-D rating scale and has been a leading voice for over four decades in the recognition and treatment of hormone-related mental illness in women. In this episode, Dr. Ashlea Broomfield speaks with Professor Jayashri Kulkarni about the mental health impact of perimenopause. They discuss the role of oestrogen and progesterone as neurosteroids influencing mood, cognition, and behaviour; why mood symptoms often precede vasomotor changes by years; which women are most at risk and why; the distinct clinical profile of perimenopausal depression and how to avoid common misdiagnoses; and how to approach hormonal treatment in practice (including contraceptive options, transdermal oestradiol, micronised progesterone, and tibolone) alongside a review of the evidence around MHT safety. RESOURCES "The primary care management of perimenopausal depression" — Kulkarni J et al. Australian Journal of General Practice 2026;55(4). Read here HER Centre Australia — Research, clinical resources, and the Meno-D scale: monash.edu/medicine/her-centre Meno-D rating scale — Available via HER Centre Australia and as an appendix in the AJGP article above Healthy Hormones — GP-led community, resources, and webinars: healthyhormones.au Australasian Menopause Society — Evidence-based guidelines and resources: menopause.org.au Monash University women's mental health short course — Via HER Centre Australia ( PMDD companion episode — The GP Show with Professor Jayashri Kulkarni (link once live) Fast Facts in Sexual and Reproductive Health with Dr. Sara Whitburn — The GP Show TIMESTAMPS 00:00 — Introduction, Welcome to Country, guest bio 03:40 — Reproductive hormones as brain neurosteroids: neurochemical effects of oestrogen and progesterone across the perimenopausal transition 12:19 — Risk factors for perimenopausal mood sensitivity: early life trauma, the HPA/HPG axis, and recognising hormonal sensitivity in clinical history 24:28 — Diagnostic considerations: the Meno-D scale, distinguishing perimenopausal depression from MDD and bipolar disorder, and current gaps in psychiatric classification 37:29 — MHT safety: reviewing the 2001 WHI study, absolute and relative contraindications, and monitoring in practice 45:33 — Treatment approaches: hormonal contraception, transdermal oestradiol, micronised progesterone, tibolone, and tailoring to the individual 59:16 — Further resources and preview of the PMDD companion episode ... If you find this podcast valuable, please help by rating the podcast 5 stars and leaving a review in your podcast app. If you would like to request a topic, please contact us via contact@thegpshow.com Thank you for listening and your support. ... Study and learn lifestyle medicine: Interested in whole of person clinical practice, research and careers that address the lifestyle and social determinants of illness and wellbeing, using lifestyle approaches, behaviour change, health coaching and implementation science? Check out the JCU College of Medicine postgraduate degrees: Graduate Certificate, Graduate Diploma, and Master in lifestyle medicine. Dr Sam Manger on YouTube: Using lifestyle as medicine: A new era in chronic disease remission and YouTube: Careers in lifestyle medicine The 3 week online microcredential in Lifestyle Medicine and Mental Health: Life and Mind available here.
    Show More Show Less
    1 hr and 2 mins
  • #221 Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (MECFS) with Dr David Fineberg

    #221 Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (MECFS) with Dr David Fineberg
    Jun 22 2026

    Dr David Fineberg is a General Practitioner and PhD candidate at the University of Melbourne whose research focuses on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long COVID. He is the founding clinician of the ME Research Clinic (MERC), a translational research hub dedicated to advancing the diagnosis, evaluation, and treatment of complex post-viral syndromes through an evidence-based, patient-centred model. His PhD is "Precision Medicine techniques In the treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome ME/CFS + Long Covid (PRIME)".

    Episodes resources:

    1. MECFS diagnostic criteria from ME Research UK
    2. DePaul Questionnaire
    3. FUNCAP (Functional Capacity) Questionnaire
    4. Open Medicine Foundation Resources and Clinical Guidelines
    5. Visible App - wearable tech for illness, not wellness, designed for MECFS, POTS, EDS and Long Covid
    6. RACGP Energy Limiting Disorders SIG and CPD CHECK

    ...

    If you find this podcast valuable, please help by rating the podcast 5 stars and leaving a review in your podcast app.

    If you would like to request a topic, please contact us via contact@thegpshow.com

    Thank you for listening and your support.

    ...

    Study and learn lifestyle medicine: Interested in whole of person clinical practice, research and careers that address the lifestyle and social determinants of illness and wellbeing, using lifestyle approaches, behaviour change, health coaching and implementation science? Check out the JCU College of Medicine postgraduate degrees: Graduate Certificate, Graduate Diploma, and Master in lifestyle medicine.

    Dr Sam Manger on YouTube: Using lifestyle as medicine: A new era in chronic disease remission and YouTube: Careers in lifestyle medicine

    The 3 week online microcredential in Lifestyle Medicine and Mental Health: Life and Mind available here.

    Show More Show Less
    1 hr and 16 mins
adbl_web_anon_alc_button_suppression_t1
No reviews yet
In the spirit of reconciliation, Audible acknowledges the Traditional Custodians of country throughout Australia and their connections to land, sea and community. We pay our respect to their elders past and present and extend that respect to all Aboriginal and Torres Strait Islander peoples today.