Treating migraine in pregnancy can be challenging since many drugs carry risks. The good news is that the FDA updated precautions on a drug-free wearable device. Molly O'Brien has the story in this Migraine Minute News Update.

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The FDA recently updated its precautionary language on the Nerivio neuromodulation device… removing the note that it has not been studied for use during pregnancy.

Based on a 2023 study published in Headache, the FDA changed the precaution to: "Users should consult their healthcare provider if they are pregnant or intend to get pregnant prior to using the device."

As we previously reported in an August 2023 Migraine Minute News update, the study's results suggest that the Nerivio device is a safe treatment for migraine during pregnancy, does not increase the risk for adverse pregnancy outcomes, and may offer a drug-free treatment option for migraine during pregnancy.

First-of-its-kind study: A new study suggests that a combination of THC + CBD works better than placebo, THC alone, or CBD alone for reducing migraine pain and symptoms. Molly O'Brien breaks it down in this Migraine Minute News Update.

Read More: https://bit.ly/4qvpuWo

A recent study found that when treating migraine attacks, a vaporized combination of THC and CBD worked better than THC alone, CBD alone, or a placebo. THC alone helped with pain, but not other symptoms, while CBD alone did not show any benefit.

Study participants who used the THC/CBD combination also saw improvements in light and sound sensitivity, but not nausea or vomiting.

No serious adverse events were reported.

In an interview with MedScape, one researcher noted that people experienced benefits without using higher, recreational doses of cannabis.

A new real-world study shows atogepant (sold under brand name Qulipta) may quickly reduce migraine days—even for those who haven't responded to other treatments. Molly O'Brien has more in this Migraine Minute News Update!

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CC License: https://creativecommons.org/licenses/by-nc-nd/4.0/

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The GIANT study, published inThe Journal of Headache and Pain, offers real-world evidence that atogepant is a safe, well-tolerated, and effective for migraine prevention—among those whose prior treatments didn't work.

Researchers looked at the impact of 60 mg of atogepant, taken once daily in people with either high-frequency episodic or chronic migraine. Many of the participants had already tried at least three other preventive treatments… including CGRP monoclonal antibodies.

Results? At 12 weeks, on average, participants saw a decrease of 6 migraine days and 11 headache days per month. In fact, nearly 60% of experienced at least a 50 percent drop in migraine days. Pain intensity, disability, and use of acute drugs also dropped.

Some saw improvement in migraine frequency within the first week.

Can diabetes and weight loss drugs help with migraine relief? A new study suggests GLP-1 medications may significantly reduce migraine days. @ Molly O’Brien has more in this Migraine Minute News Update.

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Image and license to use: Headache. 2025; 00: 1-8. http://bit.ly/47imNQO

Script: GLP-1s….a drug class widely used for diabetes and weight loss treatment, may also help migraine.

A small study published in Headache looked at liraglutide as an add-on treatment for unresponsive migraine in people with obesity who have tried at least two preventive migraine treatments. The study tracked 31 adults with high-frequency episodic or chronic migraine.

After taking a daily dose of the drug for three months, on average, they saw monthly headache days drop from about 20 to just under 11—a significant improvement. What may be surprising… is that the benefit came with insignificant weight loss.

A major study found that oral triptans work better for the acute treatment of migraine, than newer drugs. Molly O'Brien breaks it all down in this Migraine Minute News Update.

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Images and License to use: BMJ 2024;386:e080107
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Script: A major international study published in the British Medical Journal found triptans to be the most effective acute treatment for migraine.

Researchers analyzed 137 clinical trials involving nearly 90,000 adults… comparing 17 oral treatments. They looked at how many people were pain-free two hours post-dose and how many were still pain-free at 24 hours, as well as the safety and tolerability of the treatments.

They looked at how many people were pain-free at 2 hours and 24 hours, as well as the safety and tolerability of the treatments.

The top performer? Eletriptan — it was shown to be the most effective for both rapid and sustained pain relief. Other high performers included rizatriptan, sumatriptan, and zolmitriptan. Those four triptans consistently outperformed newer acute treatment options like lasmiditan, ubrogepant, and rimegepant.

These newer acute treatments worked about as well as acetaminophen and most non-steroidal anti-inflammatory drugs. Also, results showed that not all NSAIDs work the same for migraine.

Celebrating the Fourth of July with migraine is not easy. The holiday can be packed with sensory overload and migraine triggers. In this Migraine Minute, Molly O'Brien shares tips to help you enjoy the celebration while protecting your health. Check out our updated triggers webpage: https://bit.ly/4kFOZRf

Reference: https://pubmed.ncbi.nlm.nih.gov/19329386/

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While the Fourth of July can be a fun holiday to celebrate in the States, it can be tough for folks with migraine. Why? Well, there are so many factors that can be stacked against you. Think about it, heat, big crowds, staying up late, BBQ foods and drinks that might have triggering ingredients…Not to mention the bright flashes and loud bangs of fireworks. Research even shows exposure to sulfur dioxide, a common byproduct of fireworks, may trigger migraine attacks. If you have migraine and still want to enjoy the holiday, here are some tips from our migraine community: Stay hydrated, wear ear plugs, watch fireworks from afar or skip all together, bring migraine safe food and drinks to your cook out, wear sunglasses or migraine glasses, and keep a consistent routine.

Don't forget to check out AMD's updated triggers page, where you can learn more about common migraine triggers and how to manage them.

Cluster Headache Awareness Day is March 21st. In this Migraine Minute News Update Molly O'Brien explains findings from a study that found cluster headache, fibromyalgia, and migraine are frequently comorbid conditions.

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According to a study published in Neurology, when compared to placebo, this gepant led to significantly greater ability to function normally and a greater reduction in activity limitation when taken during the prodrome phase of an attack.

Molly O'Brien has the details in this Migraine Minute News Update.

Read More: https://bit.ly/3BY2J9d