Colleen Cutcliffe (Pendulum Therapeutics) is a doctor of biochemistry and microbiology and CEO and co-founder of Pendulum Therapeutics. Colleen joins the Armchair Expert to discuss starting a microbiome supplement company inspired by her premature daughter who had to take antibiotics, applying hyenas' evolved ability to digest rotting meat to study gut bacteria, and how fecal transplants reliably help treat C. diff. Colleen and Dax talk about the real linkages between microbiome and depression, obesity, and more, how the body’s natural GLP1s function, and why a healthy gut is a resilient gut. Colleen explains her wooden fence analogy to illustrate leaky guy syndrome, remarkable results from experiments giving mice Akkermansia, and that the beauty of the microbiome is that everything is recoverable.

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Charlie Puth (Whatever’s Clever, Voicenotes, Nine Track Mind) is a Grammy and Golden Globe Award-winning songwriter, recording artist, and producer. Charlie joins the Armchair Expert to discuss his opinion that standup is the scariest job, how everyone in New Jersey is their own local celebrity, and that what’s most important about recording is capturing the air in the room. Charlie and Dax talk about the photographic memory-like way he approaches sound, learning he wanted to write his own music after discovering 70s pop and R&B, and making a Christmas album that he sold door-to-door at age 11. Charlie explains why his history with his wife is like a country song, the realization that he had to remove fraudulence from his life, and embracing the beauty of imperfection in being human.

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Dax and Monica talk to Armcherries! In today's episode, Armcherries tell us about a meet cute.

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Justin Garcia (The Intimate Animal: The Science of Sex, Fidelity, and Why We Live and Die for Love) is an evolutionary biologist, researcher on sex and relationships, and Executive Director of the Kinsey Institute. Justin joins the Armchair Expert to discuss the unique quality that human sex is so tied to our social behavior, the physiological constraints on mating in other animals, and how sexually we are like magpies. Justin and Dax talk about why gorillas have really small testes, how the pandemic resulted in couples weathering the storms of relationship conflict, and an evolutionary explanation for how difficult it is to choose mates on a dating app. Justin explains how collecting hormone samples at a brothel in Las Vegas led him to write his book, why there’s no requirement to enter a relationship fully healed, and the social science behind love, partnership, fidelity, and heartbreak.

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Kaley Cuoco (Vanished, The Big Bang Theory, The Flight Attendant) is an actor and producer. Kaley returns to discuss whether she’s on the slippery slope to getting a tiger, her recent obsession with near-death experiences, and being blessed with the gift of the ability to sleep anywhere, anytime. Kaley and Dax talk about the manager-facilitated meet-cute with her now-fiancé, her hosting pitch for an NFL Honors gig, and how she has such a healthy attitude towards rejection as an actor. Kaley explains what was most memorable about walking onto Season 8 of Charmed as a new cast member, the game-changing decision to sleep in different bedrooms, and playing an archeologist in Albania on her new show Vanished.

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Dax and Monica talk to Armcherries! In today's episode, Armcherries tell us about a cooking disaster.

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Claudia Rowe (Wards of the State: The Long Shadow of American Foster Care) is a decorated journalist, advocate, and author. Claudia joins the Armchair Expert to discuss making the shift from using long-form journalism to a book to tell a story, touching off a five-year correspondence with a confessed serial killer, and confronting why she became fixated on what causes a person to commit murder. Claudia and Dax talk about her harrowing experience writing a true-crime memoir, realizing that this trial of a teenager in foster care actually corresponded to all the reporting she’d done, and how the failures of the foster system factored into the case of Maryanne. Claudia explains collaborating with incarcerated individuals to articulate thoughts about the carceral system, how poverty can often look like neglect, and her argument for a rehabilitative system of child care.

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Anderson .Paak (K-Pops!, Oxnard, Malibu) is a Grammy Award-winning songwriter, music producer, and filmmaker. Anderson joins the Armchair Expert to discuss people discovering him through his wide-ranging collaborations, how his dad and uncle were like the hood version of Freaky Friday, and feeling grateful that he took the opportunity to repair with his father before he passed. Anderson and Dax talk about how his mom turned a strawberry stand into a multimillion dollar business into a prison stay, why the best musicians come out of church bands, and staring at Dr. Dre’s feet while playing him songs for the first time. Anderson explains going viral with his Tiny Desk concert, making music videos as training to direct his first film, and why having a Trust Your Gut tattoo helps him to remember to do so.

Follow Armchair Expert on the Wondery App or wherever you get your podcasts. Watch new content on YouTube or listen to Armchair Expert early and ad-free by joining Wondery+ in the Wondery App, Apple Podcasts, or Spotify. Start your free trial by visiting wondery.com/links/armchair-expert-with-dax-shepard/ now.

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