In the sequel to last week's episode, we are back with Dr. Jonathan Davis, Director of the Heart Failure program from San Francisco General. We continue our tour of GDMT for HF, by covering SGLT2-i, MRAs, as well as some AKI and outpatient considerations. This is part 1 of 2 parts which will cover an overview of GDMT medications, and dive into Beta-blockers and ARNIs. Part 2 to come out next week!

| 00.33 - Previously on Booster Shots |

| 01.31 - Chapter 3: SGLT2-i |

• The now famous EMPA-REG OUTCOME trial [NEJM 2015]

• Empagliflozin in HFpEF (not discussed in this episode [NEJM 2021]

| 04.24 - Chapter 4: MRAs |

• RALES trial demonstrating benefit in Morbidity/Mortality [NEJM 1999]

| 10.04 - Organizing follow up |

| 11.51 - Issues with AKI |

| 15.10 - Some fun questions about Fun questions |

| 16.54 - Summary of All The Things! |

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Music by Amit Apte. Medical Heart Vectors by Vecteezy