Life has become a farcical mess for icy British A-lister Elizabeth Thornton. America's most-hated villain stars in a top-rated TV medical drama that she hates. Now, she's been romantically linked to her perky, new co-star, Summer, due to the young woman's clumsiness. As a closeted actress, that's the last thing Elizabeth needs. If she could just get her dream movie role, life would be so much better. The only problem is that the eccentric French film-maker offering it insists on meeting her "girlfriend", Summer, first.

When Claire, an overachieving psychologist with OCD tendencies, hires Lana, an impulsive, out-of-work actress for a fake relationship, she figures the worst she'll have to endure are the messes Lana leaves around. It's only for a few months anyway. And it's not as if she'll enjoy all those fake kisses and loving looks. Right?  

Morgan Ashworth isn't having a good day. The award for Minion of the Year is slipping out of reach, and she has to administer an afterlife package to one of her human employees. An employee she's attracted to. An employee who'll soon know Morgan isn't quite what she seems. Jane Smith was having a great day. Until her hot boss dropped a bombshell. It's time for Jane to complete the questionnaire to decide where she'll spend her afterlife. 

Comedian Stephanie Renshaw hopes to finally get her big break in LA. A chance encounter lands her the perfect apartment close to the comedy clubs, but it comes with a catch: She needs a roommate to afford the rent. Enter Rae Coleman, a former police officer working the door at one of the top comedy clubs. After getting injured in the line of duty and losing her job with the LAPD, Rae guards her wounded soul behind a tough exterior. At first, the two clash horribly before a tentative friendship develops. Bit by bit, Steph manages to break through the walls Rae has built around her.

Hannah Shephard likes her life, her job, and her perfectly cozy apartment around the corner from her shop. She’s never been one to take big risks and would much rather stay in on a Friday night with a warm cup of decaf and her favorite mystery novel. So, why do her friends insist she needs more? Plus, Hannah has bigger problems to focus on. She’s in trouble. Well, her bookstore is, and if she doesn’t find a way to bring in some more cash, she’ll be closing the doors of A Likely Story for good.

Kelli MacCabe is a no-nonsense detective with a tough exterior. Only a select few know her as a loyal, loving friend. Committed to her family, her friends, and her job, Kelli puts her needs behind everyone else's. As a surgeon, Nora Whitmore is used to being in control. The hospital is her life and leaves room for little else. Respected by her colleagues, but misunderstood by the residents, Nora takes what she needs and keeps everyone at arm's length. In the process, she creates unexpected enemies. Tragedy brings them together.

Cassie Miller is broke. Her parents cut off all funding when she dropped out of medical school, and graduate school is expensive. A full-time nanny job at the Wellington estate is the answer to her problems, except working for beautiful, successful Brook Wellington wasn’t in the job description. Brook has always had a head for business. Born into a global shipping empire, she sits at the helm running it with skill and savvy. But success comes at a cost. Her priority is her six-year-old son, but she can’t be in two places at once.

Captain Sabine Fleischer is a skilled and dedicated US Army surgeon deployed to a combat hospital in Afghanistan. She is also one of the thousands of troops who are forced to serve in silence because of the military's anti-gay policy of "Don't Ask, Don't Tell (DADT)". Usually driven and focused, Sabine finds that battles raging both inside and outside are making it more and more difficult for her to deal with her emotions. Dealing with loss and mortality, lack of privacy, sleep deprivation, loneliness, and the isolation forced on her by Don't Ask, Don't Tell are all taking their toll.

Veronica Welch has made it. She’s about to be named a partner at one of the most prestigious law firms in New York City. She’s on top of the world, except for one tiny ridiculous thing: She promised herself she’d be married by 35. After a drink too many, she accidentally lets her “life plan” slip to Bea, her steadfast, ever-meddling assistant, and now Bea won’t let the idea go. 

After nearly a decade as a professional drummer, Diana Petrell leaves her rock-star life behind to continue her residency in emergency medicine. She's determined not to let anything stop her - not even falling in love with her aloof mentor, Dr. Emily Barnes. Emily has only ever focused on her career as a senior attending in the emergency department, and she isn't happy about having to babysit a resident with a 10-year gap in her resume, no matter how intriguing she is. But every time they work together, it's not just their patients' heartbeat that gets a little irregular.

Half a million dollars will be Celeste Thorne’s reward for spending four years of her life in total isolation. No faces. No voices. No way to leave. Since Celeste has never really worried about being alone, the generous paycheck she’ll receive for her participation in the solitary psychological experiment seems like easy money. When she finds an injured hiker in the woods bordering her living compound, her strictly governed world is thrown into disarray.

As if juggling surgery and being an instructor isn't enough, she's recently taken on a more demanding administrative role at the medical school that was named after her legendary father. To make things worse, she's now required to attend a growing number of galas, fundraisers, and conventions. Wouldn't having a wife - a wife of convenience - help ease the burden that's threatening to overtake her world?

Julia Pierce can think of nothing more humiliating than her wife of eight years leaving her for her personal trainer. Oh, wait. She can. Without a career or a place to go when that exact thing happens, she’s forced to move home and take a job at her family’s winery. Taylor Winslow has been in love with Julia since tenth grade. Not the desperate, pining sort, but the kind that never really went away. When Julia reappears, Taylor has a chance to finally win her heart. The only problem? Julia’s hell-bent on making up for lost time by dating every eligible lesbian in town.

Have you ever met someone and felt like you’ve known them in a thousand different lifetimes? Lindsay Hall was a high school senior when she and her friend Patty discovered peach schnapps, listened to a past-life hypnosis CD, and got an up-close look at who she once was. And who she used to love. The knowledge of her past life has always haunted Lindsay. As her ex-husband is happy to point out, it’s made her a pretty crappy partner, too. Even her teenage daughter has politely suggested that she “get the eff over it.” Except she didn’t say eff.

Personal trainer Rebecca McCall is furious when her coworker is sidelined and she's forced to teach the “Be Your Best Bride” class. As if being a size two for your wedding photos is all for which exercise is good. Could the whole thing get more vain and sexist? The class is full of preening, giggling bridezillas, but one woman stands out: the one who confesses she's only there because her fiancée signed her up. Who does that to someone about whom they care? And why can't Rebecca take her eyes off her?