Ellie Fisher loves most things about being a nurse in the emergency department . . . just not working with Regina Novak, an icy attending physician who acts as if she's God's gift to medicine. The dislike is completely mutual. Regina thinks Ellie is a starry-eyed romantic with a sentimental attitude that has no place at work. When Regina gets talked into volunteering at a singles auction, Ellie accidentally bids on her—and ends up winning. Oops! Since the money raised is for a good cause, they reluctantly decide to go through with the dates.

Since A-List actress and Hollywood's sweetheart Wren Acker came out, not only is she at the top of the acting world; she's also crush number one for her queer fanbase. Loving life, loving her job, loving her cat-everything is fantastic. Except that lack of any kind of private life. When a car accident brings her to the ER, the bottom falls out of her world when she realizes that reserved Doctor Taylor, her physician, is Madison Taylor from camp way back when she was a kid. And boy, does Madison still hold a well-earned grudge for how that all ended.

It’s an ordinary workday when intelligence analyst Lexie Martin learns about a horrific chemical weapon attack abroad. Just an ordinary day...until a stranger breaks into her house and warns her to forget what she saw and heard, setting off a chain of events Lexie thought only happened in movies. Falsely accused of stealing intelligence and unsure of who to trust, Lexie quickly realizes the significance of the intel and that she must do everything she can to keep it safe. And as she runs—maybe for her life—Lexie knows she needs something, or someone, to help her.

Flirting has never been Denny’s strong suit, but so what if she’s too shy to ask women out? She’s content with her simple life, working as a cashier and helping her sister raise her niece. But then she gets a wrong-number text message from a stranger named Eliza, asking her of all people for dating advice!

Hannah Martin has an unusual job: she's a professional cuddler. While she has a big heart for her clients, she hasn't found someone special to snuggle up to in her personal life. Winter Sullivan isn't looking for love. She's an aloof workaholic who's built walls of ice around herself. She would rather drive toothpicks under her fingernails than cuddle, and she certainly doesn't want to share her space with anyone. When Winter's estranged father dies, he leaves her one last surprise: she and Hannah, a perfect stranger, will inherit a building together.

Parker Black has put her bad girl days behind her. Once the rebellious, womanizing middle child of the wealthiest family in Seattle, she's now the founder and CEO of a luxury lingerie label. But when an incident from her past resurfaces, everything she's built threatens to come crashing down. For up-and-coming public relations specialist Julia Conner, her job is her life. A former foster kid, she's spent years climbing the ladder. So when Parker contacts her to help her come back from a scandal, Julia is determined to prove she can handle a big-name client like Parker Black.

Driven, reserved businesswoman Mackenzie Watson has one goal—take over her family company and secure her little sister's future. The only wrinkle is her late grandmother's decree that her company's CEO must be married. Adding marriage into Mack's well-ordered life is a recipe for disaster. Her oh-so-logical solution? She'll just hire a woman to be her wife for a year. Besides, maybe a little chaos is exactly what she needs . . .

Falling stars are supposed to be a lucky sign, but not for Austen. Her new job as a secretary in an international games company isn't off to a good start. Her first assignment - decorating the Christmas tree in the lobby - results in a trip to the ER after Dee, the company's second-in-command, gets hit by the star-shaped tree topper. Dee blames her instant attraction to Austen on her head wound, not the magic of the falling star. She's determined not to act on it, especially since Austen has no idea that Dee is practically her boss.

When professional soccer player Alex Grey goes on a vacation to the local South Carolina islands, she isn't anticipating any life-changing events. Just a relaxing weekend to prepare for the upcoming season. But that quickly changes when she finds herself the lone witness to a sailing accident and makes the decision to risk her own life to save a drowning woman—unwittingly coming to the rescue of a US senator's wife, Catharine Cleveland.

Jules Moretti is newly single, an aspiring writer, and the hyper-competent assistant to the most powerful woman in fashion. It's a tough job, but her ice queen boss won't settle for less than perfection. Vivian Carlisle helms the internationally revered fashion publication Du Jour. She might be smack in the middle of a messy divorce, but you have to make sacrifices to be the best. That's what she tells herself, anyway. When the unthinkable happens, Vivian's regimented world is turned upside-down. Her life is about power, success, and dominance—not a baby!

Dr. Hope Finlay loves her job as an emergency room physician, especially since it allows her only brief encounters with her patients. She learned early in life not to get attached to anyone because it never lasts. Laleh Samadi, a waitress at her aunt’s restaurant, is the exact opposite. She easily connects with people and loves her big, boisterous Persian family, despite their tendency to meddle in her life. When Laleh needs to be rushed to the ER with heart trouble, Hope saves her life. Afterwards, strange things begin to occur.

Captain Sabine Fleischer is a skilled and dedicated US Army surgeon deployed to a combat hospital in Afghanistan. She is also one of the thousands of troops who are forced to serve in silence because of the military's anti-gay policy of "Don't Ask, Don't Tell (DADT)". Usually driven and focused, Sabine finds that battles raging both inside and outside are making it more and more difficult for her to deal with her emotions. Dealing with loss and mortality, lack of privacy, sleep deprivation, loneliness, and the isolation forced on her by Don't Ask, Don't Tell are all taking their toll.

Tired of disappointing dates with men, Dakota is convinced true love has passed her by. But when her lesbian friends convince her to include women in her dating app options, she instantly hits it off with NYPD detective Jack.

 Kylie and Regan have been best friends since kindergarten, supporting each other through thick and thin. While everyone thinks they would be perfect for each other, they insist there's no chemistry between them - and Regan should know since she's a chemistry teacher.

Ellie Beckett's life is simple and uncomplicated; she's on track to become a leading expert in biomedical engineering, she has a pub where she feels comfortable enough to hang out multiple times a week, and so what if she doesn't have time for . . . people? She doesn't need or want them. Until she meets Mia Sharpe. As it turns out, maybe Ellie does want at least one person.